... in synaptic transmission, as well as deficits in learning and memory ( Shields et al., 2015 ; Oettinghaus et al., 2016 ). Fig. 4. Mitochondrial fission and fusion impact on dendritic spine development. Promotion of mitochondrial fusion or fission, respectively, increases or decreases...

... by the inner-membrane peptidases YME1L (also known as YME1L1) and OMA1. Long, membrane-bound forms of OPA1 are required for mitochondrial fusion, but their processing to short, soluble forms limits fusion and can facilitate mitochondrial fission. Excessive OPA1 processing by the stress-activated protease OMA1...

.... This interaction leads to MFN1 deacetylation and activation, promoting mitochondrial fusion. Deficiency in HDAC6 or MFN1 prevents mitochondrial fusion induced by glucose deprivation. Unexpectedly, failure to undergo fusion does not acutely affect mitochondrial adaptive energy production; instead, it causes...

...Mamta Rai; Prasanna Katti; Upendra Nongthomba ABSTRACT Mitochondrial biogenesis and morphological changes are associated with tissue-specific functional demand, but the factors and pathways that regulate these processes have not been completely identified. A lack of mitochondrial fusion has been...

... of proteins involved in mitochondrial fusion and fission as regulators of Fog signaling. Pro-fission factors were found to function as enhancers of signaling, whereas pro-fusion factors were found to have the opposite effect. Consistent with this, activation of Fog signaling resulted in mitochondrial...

...Michal Cagalinec; Dzhamilja Safiulina; Mailis Liiv; Joanna Liiv; Vinay Choubey; Przemyslaw Wareski; Vladimir Veksler; Allen Kaasik Summary Mitochondrial fusion–fission dynamics play a crucial role in many important cell processes. These dynamics control mitochondrial morphology, which in turn...

... of mitochondrial DNA. To address the mode of action of Lga2, we investigated its Dnm1 (a dynamin-related protein)-dependent effects. Here, we demonstrate that Dnm1 functions as a mitochondrial fission component in U. maydis and mediates Lga2-induced mitochondrial fragmentation. Mitochondrial fusion occurred very...

...Yuka Eura; Naotada Ishihara; Toshihiko Oka; Katsuyoshi Mihara Mitofusin proteins 1 and 2 (Mfn1 and Mfn2, respectively) of the mammalian mitochondrial outer membrane are homologues of Drosophila FZO and yeast Fzo1, and both are essential for GTP-dependent mitochondrial fusion. We identified a 55-kDa...

... cycloheximide (50 μg/ml) to inhibit protein synthesis. * Author for correspondence (e-mail: [email protected] ) 2 2 2004 © The Company of Biologists Limited 2004 2004 Mitochondria Mitochondrial fusion Mitochondrial complementation Mitochondrial nucleoid...

...Ansgar Santel; Margaret T. Fuller ABSTRACT Although changes in mitochondrial size and arrangement accompany both cellular differentiation and human disease, the mechanisms that mediate mitochondrial fusion, fission and morphogenesis in mammalian cells are not understood. We have identified two...