..., fusion, extension and degradation. Fission, in particular, depends on the accumulation of mitochondrial fission factor (MFF) and subsequent recruitment of the dynamin-related protein DRP1 (also known as DNM1L). We used cryo-scanning transmission electron tomography (cryo-STET) to investigate...

...Sukrut C. Kamerkar; Ao Liu; Henry N. Higgs ABSTRACT Mitochondrial fission is important for many aspects of cellular homeostasis, including mitochondrial distribution, stress response, mitophagy, mitochondrially derived vesicle production and metabolic regulation. Several decades of research has...

.... Published by The Company of Biologists 2025 https://www.biologists.com/user-licence-1-1/ Summary: Fis1, a mitochondrial fission protein, modulates bioenergetics and selective removal of mtDNA damage in response to radiation. Interestingly, Fis1 depletion alone blunts electron transport chain...

.... and Scorrano , L. ( 2006 ). The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis . Mol. Biol. Cell 17 , 4593 - 4605 . 10.1091/mbc.e06-05-0377 Annesley , S. J. and Fisher , P. R. ( 2019 ). Mitochondria in health and disease...

... but not the Ser637 residue of the mitochondrial fission protein, dynamin-related protein 1 (DRP1, encoded by DNM1L ), via the activation of Ca 2+ -dependent kinases CaMKII, ERK and CDK1. However, optogenetically engineered Ca 2+ signaling did not activate calcineurin phosphatase to dephosphorylate DRP1 at Ser637...

... paralog, but has been lost in multiple lineages. Because of diverse structures in the C-terminal tail, Stx17 plays different roles in different organisms. Autophagy Evolution Lipid droplet Mitochondrial fission Syntaxin 17 Snx17 Japan Society for the Promotion of Science http...

... , J. M. ( 2008 ). Mitochondrial fission and fusion dynamics: the long and short of it . Cell Death Differ.   15 , 1147 - 1152 . 10.1038/cdd.2008.57 Bleicken , S. , García-Sáez , A. J. , Conte , E. and Bordignon , E. ( 2012 ). Dynamic interaction of cBid...

... - 21587 . 10.1074/jbc.C700083200 Chang , C.-R. and Blackstone , C. ( 2010 ). Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1 . Ann. N. Y. Acad. Sci.   1201 , 34 - 39 . 10.1111/j.1749-6632.2010.05629.x Chen , H. , Ren...

... for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development...

...Kirstin D. Elgass; Elizabeth A. Smith; Mark A. LeGros; Carolyn A. Larabell; Michael T. Ryan ABSTRACT Mitochondrial fission is important for organelle transport, quality control and apoptosis. Changes to the fission process can result in a wide variety of neurological diseases. In mammals...

...Anna L. Hatch; Pinar S. Gurel; Henry N. Higgs ABSTRACT Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial fission has received particular attention, owing to links...

... that treatment of cultured neonatal rat cardiomyocytes with the hypertrophic agonist norepinephrine promotes mitochondrial fission (characterized by a decrease in mitochondrial mean volume and an increase in the relative number of mitochondria per cell) and a decrease in mitochondrial function. We demonstrate...

... by The Company of Biologists Ltd 2013 Fog Mitochondria Signaling Mitochondrial fusion Mitochondrial fission Cell shape and regulation of cell shape change play an important role in the organization of tissues and organ structures. During development, the process of gastrulation is one...

...-dependent endocytosis of AMF, therefore, promotes Rac1-PI3K signaling that feeds back to promote AMF endocytosis and also inhibits the ability of Gp78 to target the mitofusins for degradation, thereby preventing Gp78-dependent mitochondrial fission. Through regulation of an ER-localized ubiquitin ligase...

... outer membrane. Expression of chimeric plasma membrane tethers rescued mitochondrial fission defects in Δ num1 and Δ mdm36 mutants. These findings provide new insights into the coupling of mitochondrial dynamics, immobilization, and retention during inheritance. Standard procedures were used...

...Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen Summary Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could provide important research tools in addition to potential leads for drug...

...Wei Qian; Serah Choi; Gregory A. Gibson; Simon C. Watkins; Christopher J. Bakkenist; Bennett Van Houten Summary Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes...

... of mitochondrial DNA. To address the mode of action of Lga2, we investigated its Dnm1 (a dynamin-related protein)-dependent effects. Here, we demonstrate that Dnm1 functions as a mitochondrial fission component in U. maydis and mediates Lga2-induced mitochondrial fragmentation. Mitochondrial fusion occurred very...

... with no effect on apoptosis. MTGM-induced mitochondrial fission can be blocked by a dominant negative Drp1 mutant (Drp1-K38A). Overexpression of MTGM also results in inhibition of cell proliferation, stalling of cells in S phase and nuclear accumulation of γ-H2AX. Knockdown of MTGM by RNA interference induces...

...Rodolfo Zunino; Astrid Schauss; Peter Rippstein; Miguel Andrade-Navarro; Heidi M. McBride Mitochondria are dynamic organelles that undergo regulated fission and fusion events that are essential to maintain metabolic stability. We previously demonstrated that the mitochondrial fission GTPase DRP1...