... altered dynamics. © 2024. Published by The Company of Biologists Ltd 2024 http://www.biologists.com/user-licence-1-1/ 26 7 2024 5 12 2024 Mitochondrial fission Fis1 Bioenergetics MtDNA Ionizing radiation © 2024. Published by The Company of Biologists Ltd. Fis1...

... mitophagy has pathophysiologic implications for oral cancer progression, indicating inhibition of MTP18-mitophagy could thus be a promising cancer therapy strategy. Apoptosis MTP18 Mitophagy Mitochondrial fission Parkin MTP18, a novel human nuclear-encoded protein with a molecular mass of 18 kDa...

... but not the Ser637 residue of the mitochondrial fission protein, dynamin-related protein 1 (DRP1, encoded by DNM1L ), via the activation of Ca 2+ -dependent kinases CaMKII, ERK and CDK1. However, optogenetically engineered Ca 2+ signaling did not activate calcineurin phosphatase to dephosphorylate DRP1 at Ser637...

..., but has been lost in multiple lineages. Because of diverse structures in the C-terminal tail, Stx17 plays different roles in different organisms. Autophagy Evolution Lipid droplet Mitochondrial fission Syntaxin 17 Snx17 Japan Society for the Promotion of Science http://dx.doi.org...

... on lipid tubes, which sets it apart from other dynamins. Drp1 stabilizes mitochondrial curvature rather than being a membrane scissor. Dynamin-related protein 1 Membrane biophysics Protein self-assembly Membrane curvature Curvature stabilizer Mitochondrial fission Deutsche...

.... Published by The Company of Biologists Ltd 2017 Summary: In this Review, we outline the machinery involved in mitochondrial fission including the recent discovery of Dnm2 as the final executor of membrane scission. An updated model of fission is presented. Drp1 Mff MiD51 Dynamin...

... for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development...

...Kirstin D. Elgass; Elizabeth A. Smith; Mark A. LeGros; Carolyn A. Larabell; Michael T. Ryan ABSTRACT Mitochondrial fission is important for organelle transport, quality control and apoptosis. Changes to the fission process can result in a wide variety of neurological diseases. In mammals...

...Anna L. Hatch; Pinar S. Gurel; Henry N. Higgs ABSTRACT Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial fission has received particular attention, owing to links...

... that treatment of cultured neonatal rat cardiomyocytes with the hypertrophic agonist norepinephrine promotes mitochondrial fission (characterized by a decrease in mitochondrial mean volume and an increase in the relative number of mitochondria per cell) and a decrease in mitochondrial function. We demonstrate...

.... , Grierson   A. J. , Sheetz   M. P. ( 2005 ). Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission.   Curr. Biol.   15 , 678 – 683 . 10.1016/j.cub.2005.02.064 Deng   H. , Dodson   M. W. , Huang   H. , Guo   M. ( 2008...

...-dependent endocytosis of AMF, therefore, promotes Rac1-PI3K signaling that feeds back to promote AMF endocytosis and also inhibits the ability of Gp78 to target the mitofusins for degradation, thereby preventing Gp78-dependent mitochondrial fission. Through regulation of an ER-localized ubiquitin ligase...

... outer membrane. Expression of chimeric plasma membrane tethers rescued mitochondrial fission defects in Δ num1 and Δ mdm36 mutants. These findings provide new insights into the coupling of mitochondrial dynamics, immobilization, and retention during inheritance. We asked whether deletion of NUM1...

...Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen Summary Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could provide important research tools in addition to potential leads for drug...

...Wei Qian; Serah Choi; Gregory A. Gibson; Simon C. Watkins; Christopher J. Bakkenist; Bennett Van Houten Summary Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes...

... of mitochondrial DNA. To address the mode of action of Lga2, we investigated its Dnm1 (a dynamin-related protein)-dependent effects. Here, we demonstrate that Dnm1 functions as a mitochondrial fission component in U. maydis and mediates Lga2-induced mitochondrial fragmentation. Mitochondrial fusion occurred very...

... with no effect on apoptosis. MTGM-induced mitochondrial fission can be blocked by a dominant negative Drp1 mutant (Drp1-K38A). Overexpression of MTGM also results in inhibition of cell proliferation, stalling of cells in S phase and nuclear accumulation of γ-H2AX. Knockdown of MTGM by RNA interference induces...

...Rodolfo Zunino; Astrid Schauss; Peter Rippstein; Miguel Andrade-Navarro; Heidi M. McBride Mitochondria are dynamic organelles that undergo regulated fission and fusion events that are essential to maintain metabolic stability. We previously demonstrated that the mitochondrial fission GTPase DRP1...

...-mail: [email protected] ) 8 9 2006 © The Company of Biologists Limited 2006 2006 Mitochondria Mitochondrial fusion Mitochondrial fission Mitofusin proteins Mitochondria are extremely dynamic organelles, and they frequently change their morphology depending upon...

... in the mitochondrial fission process. To estimate the sizes of the mitochondria associated and the cytosolic Dnm1p-GFP pools, the measured GFP fluorescence intensity of every voxel was assigned to one of theses pools. This analysis was complicated by the fact that the spatial distribution of the signals...