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Keywords: Mitochondrial dynamics
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (24): jcs258944.
Published: 15 December 2021
... advances in our understanding of how mitochondrial dynamics contribute to the regulation of mtDNA and discuss links to human disease. References Abrisch , R. G. , Gumbin , S. C. , Wisniewski , B. T. , Lackner , L. L. and Voeltz , G. K. ( 2020 ). Fission and fusion machineries...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2020) 133 (14): jcs235937.
Published: 16 July 2020
...Grigor Varuzhanyan; David C. Chan ABSTRACT Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2020) 133 (10): jcs237917.
Published: 20 May 2020
... of the mitochondrial dynamics machinery (Mgm1 and Dnm1) and ER contact sites (Gem1), regulate the flow of heme between the mitochondria and nucleus. Overall, our results indicate that there are parallel pathways for the distribution of bioavailable heme. This article has an associated First Person interview...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (4): jcs242834.
Published: 21 February 2020
... and phototoxicity. A workflow is presented to minimize the negative effects of IO for live imaging. Fluorescence microscopy Phototoxicity Cell migration Mitochondrial dynamics Microtubule dynamics Adhesion dynamics Fluorescence microscopy provides a convenient, selective and sensitive way...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs220871.
Published: 25 January 2019
..., intermediate and fragmented) were evaluated to describe mitochondrial dynamics in differently treated groups ( Fig. 4 E). Almost 90% of MEFs exhibited an intermediate mitochondrial morphology in the placebo- and EGCG-incubated groups even if not stimulated with H 2 O 2 , which made it hard to detect...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2018) 131 (7): jcs213546.
Published: 9 April 2018
... information on the molecular mechanisms of mitochondrial dynamics and neurodegenerative diseases affected by these phenomena. This article has an associated First Person interview with the first author of the paper . Competing interests The authors declare no competing or financial interests. ©...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (18): 2953–2960.
Published: 15 September 2017
... Cherok , E. , Xu , S. , Li , S. , Das , S. , Meltzer , W. A. , Zalzman , M. , Wang , C. and Karbowski , M. ( 2017 ). Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics . Mol...
Journal Articles
J Cell Sci (2017) 130 (11): 1940–1951.
Published: 1 June 2017
... Khiati ABSTRACT Mitochondrial dynamics and distribution are critical for supplying ATP in response to energy demand. CLUH is a protein involved in mitochondrial distribution whose dysfunction leads to mitochondrial clustering, the metabolic consequences of which remain unknown. To gain insight...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (7): 1274–1284.
Published: 1 April 2017
... zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Eukaryotic cells usually carry multiple copies of mitochondrial DNA (mtDNA). However, due...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2297–2306.
Published: 15 June 2016
...Thomas MacVicar; Thomas Langer ABSTRACT The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2016) 129 (5): 994–1002.
Published: 1 March 2016
... fragmentation. Appoptosin Apoptosis Mitochondrial dynamics MFN1 MFN2 MITOL Mitochondria are dynamic organelles, whose shapes continually change from filament to fragment (and vice versa) through balance between the rates of mitochondrial fusion and fission. Morphology variations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3239–3249.
Published: 1 September 2015
... apoptosis. These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis, and shed light on a link between Rbf1 and mitochondrial dynamics in vivo . * Author for correspondence ( isabelle.guenal@uvsq.fr ) Competing interests The authors declare no competing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2313–2325.
Published: 15 May 2014
...Thomas D. B. MacVicar; Jon D. Lane ABSTRACT Mitochondrial dynamics play crucial roles in mitophagy-based mitochondrial quality control, but how these pathways are regulated to meet cellular energy demands remains obscure. Using non-transformed human RPE1 cells, we report that upregulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2187–2197.
Published: 15 May 2013
... into the complex crosstalk between different processes involved in mitochondrial dynamics. This knowledge will increase understanding of the dynamic mitochondrial functions in cells and in particular, the pathogenesis of mitochondrial-related neurodegenerative diseases. Fig. 2. Mitochondrial fission...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (8): 1339–1350.
Published: 15 April 2011
... mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2632–2639.
Published: 1 August 2009
... maintenance, and that only the latter function is essential for cell viability. This parallels recent observations that have distinguished the role of OPA1, the human orthologue of Msp1p, in mitochondrial dynamics from that in cristae organization and apoptosis. Furthermore, our observations may contribute...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1707–1716.
Published: 15 May 2007
... to mutations in genes encoding mitochondrial proteins. Particularly interesting are mutations in genes such as Opa1 , Mfn1 and Dnm1l , whose products are involved in the dynamic morphological alterations and subcellular trafficking of mitochondria. These indicate that mitochondrial dynamics are especially...