...Vaibhav Deshmukh; James F. Martin ABSTRACT Mitochondria, which act as sensors of metabolic homeostasis and metabolite signaling, form a dynamic intracellular network that continuously changes shape, size and localization to respond to localized cellular energy demands. Mitochondrial dynamics...

... cells lacking SLC25A46 had an exacerbated sensitivity to lipotoxic conditions, undergoing massive apoptosis when exposed to palmitate. Therefore, in addition to its role in mitochondrial dynamics, SLC25A46 plays a role in preventing mitochondria-induced apoptosis in INS-E cells exposed to nutrient...

... advances in our understanding of how mitochondrial dynamics contribute to the regulation of mtDNA and discuss links to human disease. Mitochondrial dynamics are important for regulating many aspects of mitochondrial function, including mtDNA maintenance. As highlighted above, both fission and fusion...

...Grigor Varuzhanyan; David C. Chan ABSTRACT Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle...

... of the mitochondrial dynamics machinery (Mgm1 and Dnm1) and ER contact sites (Gem1), regulate the flow of heme between the mitochondria and nucleus. Overall, our results indicate that there are parallel pathways for the distribution of bioavailable heme. This article has an associated First Person interview...

... ). Spatial and temporal pixel binning were then investigated as tools for measuring mitochondrial dynamics. CHO-K1 cells were stained with MitoTracker™ Red and imaged with a 63×1.40 NA oil objective ( Table S9 ). In line with the lysosomal data, spatial addition generated images with higher S/N without...

.... 31 5 2018 27 11 2018 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: EGCG inhibits OMA1 self-cleavage and attenuates OPA1 cleavage, suggesting that EGCG can be used to treat IRI. Mitochondrial dynamics EGCG...

... information on the molecular mechanisms of mitochondrial dynamics and neurodegenerative diseases affected by these phenomena. This article has an associated First Person interview with the first author of the paper . * These authors contributed equally to this work ‡ Author for correspondence...

... Mitochondrial dynamics Mitochondrial fission Australian Research Council 10.13039/501100000923 DP160102176 National Health and Medical Research Council 10.13039/501100000925 It has been well documented that the mitochondrial network in cells undergoes both fission and fusion...

... Khiati ABSTRACT Mitochondrial dynamics and distribution are critical for supplying ATP in response to energy demand. CLUH is a protein involved in mitochondrial distribution whose dysfunction leads to mitochondrial clustering, the metabolic consequences of which remain unknown. To gain insight...

... zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Russian Science Foundation 10.13039/501100006769 14-50-00029 Russian Foundation...

...Thomas MacVicar; Thomas Langer ABSTRACT The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission...

... fragmentation. Appoptosin Apoptosis Mitochondrial dynamics MFN1 MFN2 MITOL National Natural Science Foundation of China 10.13039/501100001809 81225008 81161120496 91332112 91332114 U1405222 Canadian Institutes of Health China-Canada AD Initiative TAD-117950...

... apoptosis. These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis, and shed light on a link between Rbf1 and mitochondrial dynamics in vivo . ptc>+ and ptc>Debcl 2 third-instar larvae were dissected in PBS pH 7.6, fixed in PBS with formaldehyde 3.7...

...Thomas D. B. MacVicar; Jon D. Lane ABSTRACT Mitochondrial dynamics play crucial roles in mitophagy-based mitochondrial quality control, but how these pathways are regulated to meet cellular energy demands remains obscure. Using non-transformed human RPE1 cells, we report that upregulation...

... into the complex crosstalk between different processes involved in mitochondrial dynamics. This knowledge will increase understanding of the dynamic mitochondrial functions in cells and in particular, the pathogenesis of mitochondrial-related neurodegenerative diseases. * Author for correspondence...

... mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy...

... maintenance, and that only the latter function is essential for cell viability. This parallels recent observations that have distinguished the role of OPA1, the human orthologue of Msp1p, in mitochondrial dynamics from that in cristae organization and apoptosis. Furthermore, our observations may contribute...

... to mutations in genes encoding mitochondrial proteins. Particularly interesting are mutations in genes such as Opa1 , Mfn1 and Dnm1l , whose products are involved in the dynamic morphological alterations and subcellular trafficking of mitochondria. These indicate that mitochondrial dynamics are especially...