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Keywords: Mitochondrial dynamics
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Journal Articles
Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (24): jcs258944.
Published: 15 December 2021
... advances in our understanding of how mitochondrial dynamics contribute to the regulation of mtDNA and discuss links to human disease. * Authors for correspondence ( rasha.sabouny@ucalgary.ca , timothy.shutt@ucalgary.ca ) Competing interests The authors declare no competing or financial...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2020) 133 (14): jcs235937.
Published: 16 July 2020
...Grigor Varuzhanyan; David C. Chan ABSTRACT Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle...
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (4): jcs242834.
Published: 21 February 2020
... the negative effects of IO for live imaging. Fluorescence microscopy Phototoxicity Cell migration Mitochondrial dynamics Microtubule dynamics Adhesion dynamics Fluorescence microscopy provides a convenient, selective and sensitive way to observe living systems. Although modern microscopes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs220871.
Published: 25 January 2019
.... 31 5 2018 27 11 2018 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: EGCG inhibits OMA1 self-cleavage and attenuates OPA1 cleavage, suggesting that EGCG can be used to treat IRI. Mitochondrial dynamics EGCG...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (18): 2953–2960.
Published: 15 September 2017
... Mitochondrial dynamics Mitochondrial fission It has been well documented that the mitochondrial network in cells undergoes both fission and fusion events ( Friedman and Nunnari, 2014 ; Lackner, 2014 ; Richter et al., 2015 ). Fusion is important to mix mitochondrial contents to maintain a homogeneous...
Journal Articles
J Cell Sci (2017) 130 (11): 1940–1951.
Published: 1 June 2017
... Khiati ABSTRACT Mitochondrial dynamics and distribution are critical for supplying ATP in response to energy demand. CLUH is a protein involved in mitochondrial distribution whose dysfunction leads to mitochondrial clustering, the metabolic consequences of which remain unknown. To gain insight...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (7): 1274–1284.
Published: 1 April 2017
... molecules. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Summary: Uncouplers activate mitochondrial degradation in heteroplasmic yeast zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2297–2306.
Published: 15 June 2016
...Thomas MacVicar; Thomas Langer ABSTRACT The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2016) 129 (5): 994–1002.
Published: 1 March 2016
... fragmentation. Appoptosin Apoptosis Mitochondrial dynamics MFN1 MFN2 MITOL Mitochondria are dynamic organelles, whose shapes continually change from filament to fragment (and vice versa) through balance between the rates of mitochondrial fusion and fission. Morphology variations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3239–3249.
Published: 1 September 2015
... apoptosis. These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis, and shed light on a link between Rbf1 and mitochondrial dynamics in vivo . References Abdelwahid , E. , Yokokura , T. , Krieser , R. J. , Balasundaram , S. , Fowle , W. H...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (10): 2187–2197.
Published: 15 May 2013
... into the complex crosstalk between different processes involved in mitochondrial dynamics. This knowledge will increase understanding of the dynamic mitochondrial functions in cells and in particular, the pathogenesis of mitochondrial-related neurodegenerative diseases. References Benard   G. , Bellance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (8): 1339–1350.
Published: 15 April 2011
... mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2632–2639.
Published: 1 August 2009
... maintenance, and that only the latter function is essential for cell viability. This parallels recent observations that have distinguished the role of OPA1, the human orthologue of Msp1p, in mitochondrial dynamics from that in cristae organization and apoptosis. Furthermore, our observations may contribute...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1707–1716.
Published: 15 May 2007
... to mutations in genes encoding mitochondrial proteins. Particularly interesting are mutations in genes such as Opa1 , Mfn1 and Dnm1l , whose products are involved in the dynamic morphological alterations and subcellular trafficking of mitochondria. These indicate that mitochondrial dynamics are especially...