... interactions in the tumor microenvironment, effectively enhanced spheroid dissemination. Furthermore, RNA sequencing revealed significant changes at the transcriptional level in 3D spheroids compared to expression in 2D monolayers. In particular, we identified known (VEGF, AKT and mTOR) and novel (Wnt–β...

... - 391 . 10.1038/nri.2016.49 De Palma , M. , Biziato , D. and Petrova , T. V. ( 2017 ). Microenvironmental regulation of tumour angiogenesis . Nat. Rev. Cancer   17 , 457 - 474 . 10.1038/nrc.2017.51 De Sanctis , F. , Solito , S. , Ugel , S. , Molon , B...

... Microenvironment Pathophysiology Cells must interpret a complex milieu of extracellular matrix (ECM) cues to modulate intracellular signaling events linked to proliferation, differentiation and migration. Precise control of these events promotes normal tissue development and physiology, and these events...

..., are reviewed. Glioma Mechanobiology Mechanotransduction Microenvironment Neurodegeneration Differentiated tissues exhibit distinct mechanical properties ( Fig. 1 ), which direct their structure and function and reflect the composition and architecture of the extracellular matrix (ECM...

.... In conclusion, there is a great risk of oversimplifying the differences between cell culture and native tissue environments as being simply a matter of dimensionality. Instead, it is more productive to think of the classic microenvironmental cues that drive cell function – cell adhesions, mechanical forces...

... because this cell type fluctuates between periods of quiescence and active growth in response to changes in hormones and other microenvironmental effectors throughout the reproductive life of a female ( Ferguson et al., 1992 ; Keely et al., 1995 ; Stoeckelhuber et al., 2002 ; Woodward et al., 2001...

... properties of the microenvironment in cell physiology. Their discussion below will follow the path by which the microenvironment guides cells. Naturally, cell adhesion is the first cellular functional unit that responds to microenvironmental cues. It then guides actin and microtubule networks assembly...

... for correspondence and reprint requests 14 12 1990 24 01 1991 © 1991 by Company of Biologists 1991 stromal macrophages haemopoiesis microenvironment erythroblast receptor sialoadhesin (sheep erythrocyte receptor) long-term bone marrow culture glucocorticosteroids The stromal...

..., intrinsic asymmetry, microenvironment. 2 L. Wolpert Zygote ASCARIS Germ cells Fig. 1. One of the early ideas on stem cells related to the development of germ cells in Ascaris. This is from Wilson (1925). offspring that are either like itself or different? The two ways, in principle, by which this can...