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1-20 of 32
Keywords: MicroRNA
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (24): jcs262303.
Published: 13 December 2024
...Joseph Barden; Olivia Kosloski; Amir Jadidian; Mohammed Akaaboune ABSTRACT The muscle-specific microRNA miR-206 has recently emerged as a potential regulator of genes involved in the formation and regeneration of the neuromuscular junction (NMJ). This study investigated miR-206-3p (miR-206...
Includes: Supplementary data
Journal Articles
Parisa Naeli, Xu Zhang, Patric Harris Snell, Susanta Chatterjee, Muhammad Kamran, Reese Jalal Ladak, Nick Orr, Thomas Duchaine, Nahum Sonenberg, Seyed Mehdi Jafarnejad
Journal:
Journal of Cell Science
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (19): jcs261286.
Published: 11 October 2023
...Parisa Naeli; Xu Zhang; Patric Harris Snell; Susanta Chatterjee; Muhammad Kamran; Reese Jalal Ladak; Nick Orr; Thomas Duchaine; Nahum Sonenberg; Seyed Mehdi Jafarnejad ABSTRACT Viruses use microRNAs (miRNAs) to impair the host antiviral response and facilitate viral infection by expressing...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Shun Yan, Yin Peng, Jin Lu, Saima Shakil, Yang Shi, David K. Crossman, Walter H. Johnson, Jr., Shanrun Liu, Donald G. Rokosh, Joy Lincoln, Qin Wang, Kai Jiao
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (17): jcs259783.
Published: 7 September 2022
... is differentially required to regulate valve development. MicroRNA Valvulogenesis Conditional knockout Heart development National Institutes of Health R01HL095783 Congenital heart diseases (CHDs) occur in as many as 1–5% of newborns and remain the leading noninfectious cause...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Swati Priya, Ekjot Kaur, Swati Kulshrestha, Awadhesh Pandit, Isabelle Gross, Nitin Kumar, Himanshi Agarwal, Aamir Khan, Radhey Shyam, Prakash Bhagat, Jyothi S. Prabhu, Perumal Nagarajan, S. V. S. Deo, Avinash Bajaj, Jean-Noël Freund, Arnab Mukhopadhyay, Sagar Sengupta
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (15): jcs258601.
Published: 9 August 2021
... followed by RT-qPCR, which showed that the five tested DDSMs were associated with Ago2 protein (i.e. the RISC complex) ( Fig. 2 E). Fig. 2. Validation of DDSMs. (A) Alteration in microRNA levels in the absence or presence of BLM in GM03509 cells. Small RNA sequencing was performed in isogenic cell...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (12): jcs257535.
Published: 21 June 2021
... effector proteins that reduce RNA polymerase II activity on genes required for neurogenesis. miR-26b regulates neurogenesis in zebrafish by targeting ctdsp2 mRNA, but the molecular events triggered by this microRNA (miR) remain unknown. Here, we show in a murine embryonic stem cell differentiation paradigm...
Includes: Supplementary data
Journal Articles
In collection:
Nuclear structure and function
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (12): jcs258575.
Published: 17 June 2021
...-inducible factors (HIFs). Among many determinants dictating cell responses to hypoxia and HIFs are microRNAs (miRNAs). Cajal bodies (CBs), subnuclear structures involved in ribonucleoprotein biogenesis, have been recently proven to contribute to miRNA processing and biogenesis but have not been studied...
Includes: Supplementary data
Journal Articles
The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis
Qi Sun, Jiao Miao, Jing Luo, Qi Yuan, Hongdi Cao, Weifang Su, Yang Zhou, Lei Jiang, Li Fang, Chunsun Dai, Ke Zen, Junwei Yang
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (6): jcs202317.
Published: 26 March 2018
... fibrosis but the driving force in the perpetuation stage is only partially understood. To date, some investigations have specifically identified overexpression of microRNA 21 (miR-21) in the progression of kidney fibrosis. Nevertheless, the precise role of miR-21 in fibroblast activation remains largely...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (3): 569–579.
Published: 1 February 2016
... and changes endothelial microRNA expression. We found that miR-20a is decreased during EndMT, and that ectopic expression of miR-20a inhibits EndMT induction. TGFβ1 induces cellular hypertrophy in human umbilical vein endothelial cells and abrogates VE-cadherin expression, reduces endothelial sprouting...
Journal Articles
Andrew J. Modzelewski, Stephanie Hilz, Elizabeth A. Crate, Caterina T. H. Schweidenback, Elizabeth A. Fogarty, Jennifer K. Grenier, Raimundo Freire, Paula E. Cohen, Andrew Grimson
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (12): 2314–2327.
Published: 15 June 2015
... the function of microRNAs (miRNAs) and small interfering RNAs (siRNAs) during meiosis in males, we generated germ-cell-specific conditional deletions of Dgcr8 and Dicer in mice. Analysis of spermatocytes from both conditional knockout lines revealed that there were frequent chromosomal fusions during meiosis...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (2): 293–304.
Published: 15 January 2015
...William W. Du; Xianmin Li; Tianbi Li; Haoran Li; Azam Khorshidi; Fengqiong Liu; Burton B. Yang ABSTRACT The microRNA miR - 17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (1): 70–80.
Published: 1 January 2015
...Wendong Fan; Rong Fang; Xiaoyuan Wu; Jia Liu; Mingzhe Feng; Gang Dai; Guojun Chen; Guifu Wu ABSTRACT Although many studies have described the roles of microRNAs (miRNAs) in the modulation of the endothelial response to shear stress, the mechanisms remain incompletely understood. Here, we...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (7): 1585–1594.
Published: 1 April 2014
... expression and increased expression of the linc-RoR target microRNA-145 (miR-145). Linc-RoR was highly expressed in extracellular RNA released by hepatocellular cancer (HCC) cells during hypoxia. Incubation with extracellular vesicle preparations containing extracellular RNA increased linc-RoR, HIF-1α...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (6): 1169–1178.
Published: 15 March 2014
...Aránzazu Chamorro-Jorganes; Elisa Araldi; Noemi Rotllan; Daniel Cirera-Salinas; Yajaira Suárez ABSTRACT MicroRNA-149 (miR-149) is located within the first intron of the glypican-1 (GPC1) gene. GPC1 is a low affinity receptor for fibroblast growth factor (FGF2) that enhances FGF2 binding to its...
Includes: Supplementary data
Journal Articles
Norio Motohashi, Matthew S. Alexander, Yuko Shimizu-Motohashi, Jennifer A. Myers, Genri Kawahara, Louis M. Kunkel
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (12): 2678–2691.
Published: 15 June 2013
... cells located beneath the basal lamina of the myofiber, and are the principal cellular source of growth and regeneration in skeletal muscle. MicroRNAs (miRNAs) play key roles in modulating several cellular processes by targeting multiple mRNAs that comprise a single or multiple signaling pathway...
Includes: Supplementary data
Journal Articles
William W. Du, Ling Fang, Minhui Li, Xiangling Yang, Yaoyun Liang, Chun Peng, Wei Qian, Yunxia Q. O’Malley, Ryan W. Askeland, Sonia L. Sugg, Jun Qian, Jiang Lin, Zide Jiang, Albert J. Yee, Michael Sefton, Zhaoqun Deng, Sze Wan Shan, Chia-Hui Wang, Burton B. Yang
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (6): 1440–1453.
Published: 15 March 2013
...William W. Du; Ling Fang; Minhui Li; Xiangling Yang; Yaoyun Liang; Chun Peng; Wei Qian; Yunxia Q. O’Malley; Ryan W. Askeland; Sonia L. Sugg; Jun Qian; Jiang Lin; Zide Jiang; Albert J. Yee; Michael Sefton; Zhaoqun Deng; Sze Wan Shan; Chia-Hui Wang; Burton B. Yang Summary MicroRNAs are known to play...
Includes: Supplementary data
Journal Articles
Sze Wan Shan, Ling Fang, Tatiana Shatseva, Zina Jeyapalan Rutnam, Xiangling Yang, William Du, Wei-Yang Lu, Jim W. Xuan, Zhaoqun Deng, Burton B. Yang
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (6): 1517–1530.
Published: 15 March 2013
...Sze Wan Shan; Ling Fang; Tatiana Shatseva; Zina Jeyapalan Rutnam; Xiangling Yang; William Du; Wei-Yang Lu; Jim W. Xuan; Zhaoqun Deng; Burton B. Yang Summary To study the physiological role of a single microRNA (miRNA), we generated transgenic mice expressing the miRNA precursor miR-17 and found...
Includes: Supplementary data
Journal Articles
Xiaojian Xu, Shumin Wang, Juan Liu, Dou Dou, Limei Liu, Zhengju Chen, Liping Ye, Huixia Liu, Qiong He, J. Usha Raj, Yuansheng Gao
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (24): 6117–6126.
Published: 15 December 2012
... of sGC is obligatory for the biological stability and activity of the sGC heterodimer. MicroRNAs (miRNAs) are important regulators of gene expression and exert great influences on diverse biological activities. The aim of the present study was to determine whether or not the expression of sGCβ 1...
Journal Articles
Noel Faherty, Simon P. Curran, Helen O’Donovan, Finian Martin, Catherine Godson, Derek P. Brazil, John K. Crean
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (23): 5621–5629.
Published: 1 December 2012
... nephropathy and has been implicated in cellular differentiation. To investigate the potential role of microRNAs (miRNAs) in the mediation of this signalling network, we performed miRNA screening in mesangial cells treated with recombinant human CCN2. Analysis revealed a cohort of 22 miRNAs differentially...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (18): 4179–4787.
Published: 15 September 2012
... of generating pluripotent stem cells. Here, we discuss recent findings that show that, in addition to transcription factors, microRNAs can promote pluripotent reprogramming and can even substitute for these pluripotency transcription factors in some cases. Taking into consideration that microRNAs have...
Journal Articles
Katarzyna Goljanek-Whysall, Helio Pais, Tina Rathjen, Dylan Sweetman, Tamas Dalmay, Andrea Münsterberg
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (15): 3590–3600.
Published: 1 August 2012
...Katarzyna Goljanek-Whysall; Helio Pais; Tina Rathjen; Dylan Sweetman; Tamas Dalmay; Andrea Münsterberg Summary MicroRNAs are short non-coding RNAs involved in post-transcriptional regulation of multiple messenger RNA targets. The miR-1/miR-206 family is expressed during skeletal muscle...
Includes: Supplementary data
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