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Keywords: Metastasis
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Journal Articles
J Cell Sci jcs.260243.
Published: 9 January 2023
... cancer patients. To investigate whether the kinase activity is essential for FER oncogenic properties, we developed an ATP analogue-sensitive knock-in allele (FER ASKI ). Specific FER kinase inhibition in MDA-MB-231 cells reduces migration, invasion, and metastasis in a mouse model of breast cancer...
Journal Articles
J Cell Sci (2022) 135 (18): jcs260244.
Published: 14 September 2022
... discovery over 40 years ago. Here, we will describe recent insights into the roles of TNC in tumorigenesis, angiogenesis, immunity and metastasis. In addition to high levels of expression in tumors, and during chronic inflammation, and bacterial and viral infection, TNC is also expressed in lymphoid organs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048 RSG-20-019...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (21): jcs258418.
Published: 5 November 2021
...-associated transcripts; ETs). Of these, the ET-20 gene localizes in antisense orientation within the tenascin C ( Tnc ) gene locus. TNC is an extracellular matrix protein that is critical for EMT and metastasis formation. Both ET-20 and Tnc are regulated by the EMT master transcription factor Sox4. Notably...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (19): jcs258431.
Published: 13 October 2021
...Craig E. Barcus; Priscilla Y. Hwang; Vasilios Morikis; Audrey Brenot; Patrick Pence; Maria Clarke; Gregory D. Longmore ABSTRACT Both tumor cell-intrinsic signals and tumor cell-extrinsic signals from cells within the tumor microenvironment influence tumor cell dissemination and metastasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs240135.
Published: 10 August 2021
... ). To determine the overall contribution of CD99 expression to metastasis and tumour progression we used an in vivo model. When injected into the tail vein of immunodeficient mice, the MDA-MB-231 cell line preferentially metastasises to the lungs. We used luciferase-expressing MDA-MB-231 cells, transfected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247056.
Published: 22 January 2021
... on diverse cell biological processes involved in metastasis. * Author for correspondence ( Jayanta.Debnath@ucsf.edu ) Competing interests J.D. is a Scientific Advisory Board Member for Vescor Therapeutics, LLC. T.M. is employed by Casma Therapeutics. © 2021. Published by The Company...
Journal Articles
J Cell Sci (2020) 133 (11): jcs237222.
Published: 11 June 2020
... morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with poor patient's prognosis. BMP4...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241505.
Published: 11 May 2020
... cancer. Particular fusion variants act through a novel actionable pathway involving NEK7 and NEK9, promoting cell migration and potentially influencing metastatic progression. EML4–ALK EML4 NEK9 NEK7 NSCLC Microtubules Cell migration Metastasis The EML4–ALK translocation...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2019) 132 (20): jcs232645.
Published: 28 October 2019
... activates VLA-4-mediated motility has remained unknown. We now report that VEGFR2 causes PKA-mediated phosphorylation of VLA-4 on S988, an event known to stimulate tumor metastasis while suppressing cytotoxic immune cells. A key partner in this mechanism is the chemokine receptor CXCR4, a well-known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs231514.
Published: 9 October 2019
..., the coordinated movement of cohesive packs of cells, has become recognized as a major mode of metastasis for solid tumors. These packs are phenotypically heterogeneous and include specialized cells that lead the invasive pack and others that follow behind. To better understand how these unique cell types...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs231563.
Published: 9 September 2019
...Tyler A. Allen; Dana Asad; Emmanuel Amu; M. Taylor Hensley; Jhon Cores; Adam Vandergriff; Junnan Tang; Phuong-Uyen Dinh; Deliang Shen; Li Qiao; Teng Su; Shiqi Hu; Hongxia Liang; Heather Shive; Erin Harrell; Connor Campbell; Xinxia Peng; Jeffrey A. Yoder; Ke Cheng ABSTRACT Metastasis accounts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (15): jcs228213.
Published: 31 July 2019
...Yang Tian; Chunying Wang; Shuohua Chen; Jie Liu; Yan Fu; Yongzhang Luo ABSTRACT Extracellular heat shock protein 90 alpha (eHsp90α, also known as HSP90AA1) has been widely reported to promote tumor cell motility and tumor metastasis in various types of cancer. Several extracellular proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs219907.
Published: 10 December 2018
.... Arrowheads indicate nuclei. Scale bars: 100 μm. n=3 independent repeats. As the macroscopic structure of the lung had been preserved, but cellular material eliminated, we used this DCM to investigate the behaviour of metastasising cancer cells. The breast cancer cell lines MCF7 and MDA231 originate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs212563.
Published: 23 August 2018
... by The Company of Biologists Ltd 2018 Summary: Induction of BIM and BMF function in metastatic breast cancer can aid current treatment strategies. Breast cancer Intrinsic apoptosis Metastasis Because evasion of apoptosis is considered as a hallmark of cancer ( Hanahan and Weinberg, 2000...
Journal Articles
J Cell Sci (2017) 130 (20): 3455–3466.
Published: 15 October 2017
... may undergo metastasis. Melanoma Metastasis LPA LPP3 Self-generated gradients Chemotaxis Malignant melanoma is the most aggressive form of skin cancer, accounting for the majority of skin cancer-related deaths ( American Cancer Society, 2014 ). Melanoma is highly treatable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3399–3413.
Published: 1 October 2017
...) inhibited MDA-MB-231 and MCF-7 cell metastasis by repressing epithelial–mesenchymal transition (EMT) in vitro , and suppressed breast cancer metastasis in vivo . Mechanistically, the CCR2 3′UTR modulated the expression of the RhoGAP protein STARD13 via acting as a STARD13 ceRNA in a microRNA-dependent...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2017) 130 (4): 663–669.
Published: 15 February 2017
... dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (23): 4341–4353.
Published: 1 December 2016
... inhibits cancer metastasis, at least in part, by blocking invadopodia-dependent ECM degradation and invadopodia extension. To test this hypothesis, we analyzed the effect of miR-204 mimic on invadopodia formation using MDA-MB-231 cells embedded in a Matrigel–collagen-I matrix ( Fig. 6 C,D; also see Figs 1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1355–1365.
Published: 1 April 2016
... are important activities for invadopodia function. Importantly, we show that depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis. © 2016. Published...
Includes: Supplementary data