... Adhesion complex Adhesome Growth factor receptors Proliferation Cell cycle Apoptosis Anoikis Differentiation Stem cells Mitosis Metaphase Mitotic spindle Cell fate Adhesion The formation of complex tissues, including the different types of cells within them and their spatial...

...Jun-Yong Huang; Gary Morley; Deyu Li; Michael Whitaker Anaphase-promoting complex or cyclosome (APC/C) controls the metaphase-to-anaphase transition and mitosis exit by triggering the degradation of key cell cycle regulators such as securin and B-type cyclins. However, little is known about...

...Heng-Yu Chang; Mark Levasseur; Keith T. Jones Metaphase II-arrested mouse eggs are stimulated to complete meiosis by sperm-induced Ca 2+ spiking. The Ca 2+ signal causes activation of the E3 ligase anaphase-promoting complex/cyclosome (APC), leading to the destruction of key proteins necessary...

...Sarah E. Lee; Sanne Jensen; Lisa M. Frenz; Anthony L. Johnson; Didier Fesquet; Leland H. Johnston In eukaryotes an abnormal spindle activates a conserved checkpoint consisting of the MAD and BUB genes that results in mitotic arrest at metaphase. Recently, we and others identified a novel Bub2...