...Neville Cobbe; Kathryn M. Marshall; Shubha Gururaja Rao; Ching-Wen Chang; Francesca Di Cara; Edward Duca; Sharron Vass; Adam Kassan; Margarete M. S. Heck Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell...

... invasion and metastasis. However, recent findings indicate that different proteases can also act as tumor-suppressor enzymes. We have recently reported that lung carcinoma cells expressing the ADAMTS-12 metalloprotease show a remarkable impairment of growth in immunodeficient mice as compared with parental...

... of a constitutively active Notch-1, or co-culture of myogenic cells with CHO cells transfected with Delta like-1 (DLL1), increases the level of Pax7. DLL1, a ligand for Notch receptor, is shed by ADAM metalloproteases in a pool of Pax7 + C2C12 reserve cells, but it remains intact in differentiated myotubes. DLL1...

...Emilia Mira; Rosa Ana Lacalle; José María Buesa; Gonzalo González de Buitrago; Sonia Jiménez-Baranda; Concepción Gómez-Moutón; Carlos Martínez-A; Santos Mañes Association of matrix metalloprotease 9 (MMP9) to the cell membrane is considered important in tumor growth and angiogenesis...

...Juliette Longin; Patricia Guillaumot; Marie-Agnès Chauvin; Anne-Marie Morera; Brigitte Le Magueresse-Battistoni Metalloproteases (MMPs) are likely to be involved in the restructuring events occurring in the testis throughout development. We here demonstrate that membrane-type 1 (MT1)-MMP...

... the intracellular domain and is shed from the transmembrane protein by a metalloprotease. Release from cells and brain slices is stimulated by HA and by phorbol ester, and it is blocked by a metalloprotease inhibitor and by lowering the temperature to 20°C. Blockade of SorLA shedding and treatment of cells...

... and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of metargidin contains an RGD tripeptide sequence...