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Keywords: Metabolism
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Journal Articles
In collection:
Cell cycle , Metabolism
J Cell Sci (2023) 136 (16): jcs260787.
Published: 15 August 2023
...Yipeng Du; Parul Gupta; Shenlu Qin; Matthew Sieber ABSTRACT Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in physiology and metabolism. Quiescence plays essential roles in a wide variety of biological processes, ranging from microbial sporulation...
Journal Articles
J Cell Sci (2022) 135 (8): jcs259611.
Published: 19 April 2022
... mechanisms of metabolic and biomechanical regulations that coordinate plant cell growth non-cell-autonomously. This reveals how metabolism and mechanics are not solely passive outcomes of genetic regulation but play instructive roles in leaf morphogenesis. Such an integrative view also extends to fluctuating...
Journal Articles
J Cell Sci (2022) 135 (5): jcs259402.
Published: 9 March 2022
... Metabolism National Institutes of Health http://dx.doi.org/10.13039/100000002 R00AA026877 R01DK044650 R01AA020735 Lipid droplets (LDs) play important roles in numerous cell types across virtually all species. Beyond serving as energy-rich lipid reservoirs for the breakdown of fatty...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2021) 134 (5): jcs252023.
Published: 8 February 2021
...Lena Pernas ABSTRACT The study of metabolic changes associated with host–pathogen interactions have largely focused on the strategies that microbes use to subvert host metabolism to support their own proliferation. However, recent reports demonstrate that changes in host cell metabolism can also...
Journal Articles
In collection:
Metabolism
J Cell Sci (2020) 133 (10): jcs239467.
Published: 27 May 2020
... consumption. Furthermore, Smed-Sirt-1(RNAi) animals displayed reduced cell death and increased stem cell proliferation accompanied by impaired expression of intestinal lineage progenitors and reduced branching of the gut. Taken together, our findings indicate that Sirtuin-1 is a crucial metabolic hub capable...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2019) 132 (8): jcs230649.
Published: 17 April 2019
... further found that ATP concentration is not necessarily an indicator of metabolic activity, as there is no clear correlation between ATP level and growth rates. During fission yeast meiosis, we found a reduction in ATP levels, suggesting that ATP homeostasis is controlled by differentiation. The use...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2018) 131 (17): jcs223289.
Published: 5 September 2018
...Krisna C. Duong-Ly; Yin-Ming Kuo; Matthew C. Johnson; Joy M. Cote; Justin M. Kollman; Jonathan Soboloff; Glenn F. Rall; Andrew J. Andrews; Jeffrey R. Peterson ABSTRACT T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Metabolism
J Cell Sci (2017) 130 (4): 663–669.
Published: 15 February 2017
... dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (18): 3367–3373.
Published: 15 September 2016
...Alexei Vazquez; Jurre J. Kamphorst; Elke K. Markert; Zachary T. Schug; Saverio Tardito; Eyal Gottlieb ABSTRACT A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism , Stem cells
J Cell Sci (2015) 128 (24): 4467–4474.
Published: 15 December 2015
... such example, the quiescent adult mammalian stem cell, and examines concepts underlying our understanding of quiescence that can be attributed to studies in yeast. We discuss the metabolic, signaling and gene regulatory events that control entry and exit into quiescence in yeast. These processes and events...
Journal Articles
In collection:
Metabolism
J Cell Sci (2015) 128 (13): 2319–2329.
Published: 1 July 2015
... on the assembly of the spindle, chromosome alignment and ATP content. Pyruvate dehydrogenase kinase Oocyte Meiosis Metabolism Spindle Oocyte development is key in establishing female fertility. At around the time of birth, mammalian oocytes are arrested in prophase of the first meiotic division...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2015) 128 (10): 1982–1990.
Published: 15 May 2015
... and reactive oxygen species (ROS). LPS activation also skews the metabolism of macrophages towards a glycolytic phenotype. Here, we demonstrate that the LPS-triggered glycolytic switch is significantly attenuated in macrophages deficient for glutathione transferase omega-1 (GSTO1, note that GSTO1-1 refers...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2014) 127 (20): 4331–4341.
Published: 15 October 2014
... on angiogenesis has revealed key mechanisms that regulate tissue vascularization, therapeutic success has been limited owing to insufficient efficacy, refractoriness and tumor resistance. Emerging concepts suggest that, in addition to growth factors, vascular metabolism also regulates angiogenesis and is a viable...
Journal Articles
Journal Articles
In collection:
Metabolism
J Cell Sci (2014) 127 (10): 2282–2290.
Published: 15 May 2014
... diverse effects on mitochondrial metabolism and biogenesis, but the role of the mitochondrial genotype in mediating these effects remains unknown. Here, we use novel mitochondrial genome replacement strains in Drosophila to test the hypothesis that genes encoded in mitochondrial DNA (mtDNA) influence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1857–1867.
Published: 1 May 2014
... the pathways that communicate between lipid, amino acid, nucleotide and sugar metabolism. This research is anticipated to provide crucial insights that will allow us to both better understand the various disease states that can arise from such metabolic defects. Funding The work of our laboratory...
Journal Articles
Journal Articles
In collection:
Metabolism
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 1 December 2012
...Victoria A. Rafalski; Elena Mancini; Anne Brunet Summary Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent...