... bilayers, which is drastically decreased in a paracrine-deficient mutant of EN2. We propose that the bidirectional plasma membrane translocation events that occur during homeoprotein secretion and internalization are parts of a common process. * Author for correspondence (alain.joliot@college-de...

... in the extracellular space. Here we demonstrate that FGF2 membrane translocation can occur in a folded conformation, i.e. unfolded molecules are not obligatory intermediates in FGF2 secretion. Furthermore, we find that initial sorting into its export pathway requires FGF2 to be folded, because the interaction...

...-heidelberg.de 23 5 2007 © The Company of Biologists Limited 2007 2007 Fibroblast growth factor 2 Membrane translocation Unconventional protein secretion Nonclassical export The majority of extracellular proteins are exported from cells through the classical endoplasmic reticulum...

...-mail: [email protected]) 17 4 2007 © The Company of Biologists Limited 2007 2007 Epimorphin Integrin Morphogenesis Membrane translocation t-SNARE Morphogenesis, the orchestration of tissue remodeling with cell proliferation, differentiation and apoptosis...

... al., 2000 ; Reif et al., 2001). * Author for correspondence (e-mail: [email protected]) 7 6 2005 © The Company of Biologists Limited 2005 2005 Citrate carrier Mitochondria Membrane translocation Protein targeting to mitochondria is mediated by several...

...Rafael Backhaus; Christoph Zehe; Sabine Wegehingel; Angelika Kehlenbach; Blanche Schwappach; Walter Nickel Endoplasmic reticulum/Golgi-dependent protein secretion depends on signal peptides that mediate membrane translocation of nascent secretory proteins into the lumen of the endoplasmic reticulum...

... Limited 2002 2002 Non-conventional protein secretion Non-classical protein export Membrane translocation Extracellular FGF-2 FGF-2 signalling FGF-2 microdomains Proteins destined for the classical pathway of eukaryotic secretion typically contain an N-terminal signal peptide(Walter et...

... of peroxisomal protein import is demonstrated by the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy, in which there is a global failure of peroxisomal matrix protein import (Fujiki, 1997). Peroxisomes Microbodies Protein trafficking Membrane translocation...