... to can or must) use the TRC pathway in intact cells generates a comprehensive list of human TRC40 clients. TRC40 Chaperone Client spectrum Endoplasmic reticulum Membrane targeting Tail-anchored protein The presence of membrane proteins customizes biological membranes to suit...

... of Biologists Limited 2007 2007 VAMP4 SNARE Endosome Golgi complex TGN Membrane targeting Protein transport in the secretory and endocytic pathways is mediated by membrane-enclosed intermediates in the form of small vesicles or larger containers. These shuttling vehicles are generated from...

... the full length (>708 amino acids) of the protein was required for normal prestin expression and function. Since most deletion mutations eliminated plasma membrane targeting, chimeric proteins were constructed by fusing prestin, at amino acid 515 or 644, with the homologous portion of the C-terminus...

... of RabF and RabSF regions in membrane targeting, we created hybrid proteins based on either Rab5a or Rab27a by exchanging residues within the RabF and RabSF regions between the two proteins. In most cases, targeting was not affected (our unpublished results). One example is the introduction of the Rab27a...

... © The Company of Biologists Limited 2004 2004 Metalloprotease Tumor growth Angiogenesis Lipid rafts Membrane targeting Increasing evidence suggests that matrix metalloproteases (MMP), a family of multidomain, zinc-containing neutral endopeptidases, contribute to the formation...