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Keywords: Membrane contact sites
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Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (5): jcs255026.
Published: 20 April 2021
...Yuan Gao; Juan Xiong; Qing-Zhu Chu; Wei-Ke Ji ABSTRACT Membrane contact sites (MCSs) between the endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs249136.
Published: 29 December 2020
... then used to instigate a local release of Ca 2+ on demand. Here, communication between organelles comes into play, which is accomplished through intimate yet dynamic contacts, termed membrane contact sites (MCSs). The field of MCS biology in relation to cellular Ca 2+ homeostasis has exploded in recent...
Journal Articles
J Cell Sci (2020) 133 (11): jcs243733.
Published: 04 June 2020
... methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 . Syst. Biol.   59 , 307 - 321 . 10.1093/sysbio/syq010 Hanada , K. ( 2018 ). Lipid transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites . J. Lipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs215335.
Published: 19 July 2018
... complex Membrane contact sites Phosphatidylinositol 4-phosphate The endoplasmic reticulum (ER) is the major site for synthesis of lipids and cholesterol, which are subsequently distributed to other organelles by vesicular transport or lipid transfer proteins (LTPs) that shield the ligand from...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (2): 360–371.
Published: 15 January 2017
... determinants of cell fate. Bcl-2 proteins Ceramide transfer protein Cytochrome c Endoplasmic reticulum Membrane contact sites Mitochondrial apoptosis VAP receptor Apoptosis is a form of programmed cell death with a crucial role in organismal development and tissue homeostasis...
Journal Articles
J Cell Sci (2015) 128 (11): 2096–2105.
Published: 01 June 2015
... remodeling of the cER. Although an association between Kv2.1 clusters and the ER has been established ( Antonucci et al., 2001 ; Du et al., 1998 ; Mandikian et al., 2014 ), the results presented above indicate that Kv2.1 plays a direct role in forming a membrane contact site (MCS) comprising the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 60–66.
Published: 01 January 2013
... heterogeneous Ca 2+ oscillations that required ER-localised inositol trisphosphate receptors. Electron microscopy identified extensive membrane contact sites between lysosomes and the ER. Mobilisation of lysosomal Ca 2+ stores is thus sufficient to evoke ER-dependent Ca 2+ release probably through lysosome–ER...
Journal Articles
J Cell Sci (2012) 125 (20): 4791–4799.
Published: 15 October 2012
... Endoplasmic reticulum Mitochondria Lipid trafficking Membrane contact sites Reticulons ERMES complex Sey1p The endoplasmic reticulum (ER) forms an elaborate, dynamic network of sheets and tubules that extends throughout the cytoplasm. The complex structure of the ER is determined by a number of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 49–58.
Published: 01 January 2012
...Alexandre Toulmay; William A. Prinz Membrane contact sites (MCSs), where the membranes of two organelles are closely apposed, are regions where small molecules such as lipids or calcium are exchanged between organelles. We have identified a conserved membrane-binding domain found exclusively in...
Includes: Supplementary data