... are required for cellular lipid homeostasis. The lysosomal protein LIMP-2 (also known as SCARB2) forms membrane contact sites with the endosomal protein STARD3 and the ER-localized VAPB. ER–lysosome contact sites Lipid transport Lysosome LIMP-2 SCARB2 Membrane contact sites STARD3 VAPB Lysosome...

.... Endoplasmic reticulum ER Mitosis Cell division ER dynamics and morphology ER–cytoskeleton contacts Membrane contact sites State Parliament of Baden-Württemberg Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 SCHL1876/2-3 Mitotic cell division...

...Maria Clara Zanellati; Chih-Hsuan Hsu; Sarah Cohen ABSTRACT Eukaryotic cells are compartmentalized into membrane-bound organelles that must coordinate their responses to stimuli. One way that organelles communicate is via membrane contact sites (MCSs), sites of close apposition between organelles...

...: The Nir2 and Nir3 lipid transfer proteins maintain phosphoinositide signaling and actin dynamics, supporting effective phagocytosis. Immunity Cytoskeleton Lipid transfer Membrane contact sites Cell signaling Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung...

.... Cell Biol. 12 , 267 - 272 . 10.1038/ncb2026 Eden , E. R. , Sanchez-Heras , E. , Tsapara , A. , Sobota , A. , Levine , T. P. and Futter , C. E. ( 2016 ). Annexin A1 tethers membrane contact sites that mediate ER to endosome cholesterol transport . Dev. Cell...

... of membrane contact sites (MCSs). Finally, we explore the opportunistic hijacking of Ub and Ubl modification cascades by intracellular bacteria that remodel host trafficking pathways to invade and prosper inside cells. * Author for correspondence ( [email protected] ) Competing interests...

.... ( 2015 ). Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth . Nature 520 , 234 - 238 . 10.1038/nature14359 Raiborg , C. , Wenzel , E. M. , Pedersen , N. M. and Stenmark , H. ( 2016 ). Phosphoinositides in membrane contact sites...

... plasticity of mitochondria in live yeast . Proc. Natl. Acad. Sci. USA 99 , 3370 - 3375 . 10.1073/pnas.052545099 Eisenberg-Bord , M. , Shai , N. , Schuldiner , M. and Bohnert , M. ( 2016 ). A tether is a tether is a tether: tethering at membrane contact sites . Dev. Cell...

...Christopher Henry; Amado Carreras-Sureda; Nicolas Demaurex ABSTRACT Recruitment of STIM proteins to cortical endoplasmic reticulum (cER) domains forming membrane contact sites (MCSs) mediate the store-operated Ca 2+ entry (SOCE) pathway essential for human immunity. The cER is dynamically regulated...

... between organelles, the possible functions of such transport and the underlying molecular mechanisms. Membrane contact sites Membrane homeostasis Protein-mediated lipid transport National Institutes of Health http://dx.doi.org/10.13039/100000002 R01GM135290 R35GM131715...

... in the regulation of both ER and mitochondrial Ca 2+ homeostasis and in glucose-dependent ATP production in insulin-secreting cells. Membrane contact sites Ca 2+ Insulin secretion Phosphoinositides Mitochondria Novo Nordisk Fonden http://dx.doi.org/10.13039/501100009708 NNF19OC0055275...

...-dependent anion channel highlights the importance of endoplasmic reticulum–mitochondria membrane contact sites in maintaining organelle morphology. VDAC Porin Mitochondria Mitochondrion ER Ca 2+ Toxoplasma Motility Membrane contact sites Biotechnology and Biological Sciences Research...

...Yuan Gao; Juan Xiong; Qing-Zhu Chu; Wei-Ke Ji ABSTRACT Membrane contact sites (MCSs) between the endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While...

... are then used to instigate a local release of Ca 2+ on demand. Here, communication between organelles comes into play, which is accomplished through intimate yet dynamic contacts, termed membrane contact sites (MCSs). The field of MCS biology in relation to cellular Ca 2+ homeostasis has exploded in recent...

...://www.biologists.com/user-licence-1-1/ Summary: Osh6 transports phosphatidylserine to the plasma membrane. The membrane localization and lipid transfer activity of Osh6 is regulated by the tail region of the ER–PM tether protein Ist2. Lipid transfer protein Membrane contact sites Phosphatidylserine...

...://www.biologists.com/user-licence-1-1/ Summary: ORP4L localization to contact sites between the Golgi and endoplasmic reticulum involves interaction with OSBP and PI(4)P, and is required for organelle structure and PI(4)P content. Oxysterol binding proteins Golgi complex Membrane contact sites...

... Endoplasmic reticulum Membrane contact sites Mitochondrial apoptosis VAP receptor Highlighted Article: This work shows that mitochondrial translocation of ER ceramides specifically induces apoptosis and highlights a novel approach for probing compartment-specific functions of these biomolecules...

... , A. , Michel , A. H. and Kornmann , B. ( 2013 ). Organization and function of membrane contact sites . Biochim. Biophys. Acta   1833 , 2526 - 2541 . 10.1016/j.bbamcr.2013.01.028 Hogan , P. G. , Lewis , R. S. and Rao , A. ( 2010 ). Molecular basis of calcium signaling...

... heterogeneous Ca 2+ oscillations that required ER-localised inositol trisphosphate receptors. Electron microscopy identified extensive membrane contact sites between lysosomes and the ER. Mobilisation of lysosomal Ca 2+ stores is thus sufficient to evoke ER-dependent Ca 2+ release probably through lysosome–ER...

...   G. ( 1991 ). Mitochondrial membrane contact sites of yeast. Characterization of lipid components and possible involvement in intramitochondrial translocation of phospholipids.   J. Biol. Chem.   266 , 10047 – 10049 . Sogo   L. F. , Yaffe   M. P. ( 1994 ). Regulation...