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Keywords: Meiosis
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Journal Articles
J Cell Sci (2021) 134 (7): jcs258391.
Published: 15 April 2021
... male sterility. Immunofluorescence and fluorescent in situ hybridization revealed that Ipo9 KO mutants display chromosome condensation and segregation defects during meiosis. In addition, Ipo9 KO mutant males form abnormally structured sperm and fail to properly exchange histones for protamines. Ipo9...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (3): jcs238543.
Published: 08 February 2021
...Xiangchuan Wang; Dandan Zhang; Cunni Zheng; Shian Wu; Michael Glotzer; Yu Chung Tse ABSTRACT Haploid male gametes are produced through meiosis during gametogenesis. Whereas the cell biology of mitosis and meiosis is well studied in the nematode Caenorhabditis elegans , comparatively little is known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs249128.
Published: 11 December 2020
... of temporal and spatial control of translation remains unclear. In oocytes, many mRNAs are deposited as a translationally repressed form and are translated at appropriate times to promote the progression of meiosis and development. Here, we show that changes in subcellular structures and states of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248831.
Published: 04 December 2020
...Stephen R. Wellard; Karen Schindler; Philip W. Jordan ABSTRACT Precise control of chromosome dynamics during meiosis is critical for fertility. A gametocyte undergoing meiosis coordinates formation of the synaptonemal complex (SC) to promote efficient homologous chromosome recombination. Subsequent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs253724.
Published: 30 November 2020
... thermophila , the meiotic prophase nucleus stretches enormously, and chromosomes assume a bouquet-like arrangement in which telomeres and centromeres are attached to opposite poles of the nucleus. We have identified and characterized three meiosis-specific genes [meiotic nuclear elongation 1-3 ( MELG1-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243667.
Published: 12 August 2020
...Adél Sepsi; Trude Schwarzacher ABSTRACT During prophase I of meiosis, homologous chromosomes pair, synapse and exchange their genetic material through reciprocal homologous recombination, a phenomenon essential for faithful chromosome segregation. Partial sequence identity between non-homologous...
Journal Articles
J Cell Sci (2021) 134 (5): jcs245753.
Published: 30 June 2020
... investigate the non-canonical modes of chromosome segregation and cell division in Plasmodium . Mitosis and meiosis are fundamental processes in cell division that enable DNA replication and chromosome segregation, and allow eukaryotic organisms to proliferate, propagate and survive. During these processes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs242701.
Published: 16 June 2020
... mouse testes indicated that meiosis-associated mRNAs bound by LIN28A were differentially expressed. Next, ribosome profiling revealed that the mRNA levels of these targets were significantly reduced in the polysome fractions, and their protein expression levels decreased, in Lin28a -null mouse testes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240234.
Published: 08 June 2020
... underwent the typical three phases of spindle elongation, they have distinct features. We found that the relative concentration of the kinesin-14 family protein Pkl1 is decreased in meiosis I compared to mitosis, while the concentration of the kinesin-5 family protein Cut7 remains constant. We identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs238709.
Published: 22 May 2020
... disruptions in chromosome segregation during meiosis I and II. Rec8 cohesin dynamics are altered in the absence of the TLSPs. These data suggest that the TLSPs contribute to multiple aspects of meiotic chromosome dynamics. * Present address: Division of Biology and Biological Engineering, California...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs233379.
Published: 26 September 2019
...-depleted mouse oocytes progress normally through early meiosis I, but that anaphase I fails as a result of persistent Cdk1 activity. Unexpectedly, Cdk1 inactivation was compromised following Cep55 depletion, despite on-time SAC silencing and intact APC-mediated proteolysis. We found that impaired Cdk1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (14): jcs232330.
Published: 18 July 2019
... dynamic protein localisation in the central spindle during female meiosis I in Caenorhabditis elegans . Meiosis Oocytes SUMO Chromosomes Segregation Spindle Faithful chromosome partitioning is essential for accurate cell division and is achieved by physically separating chromatids, or...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs230649.
Published: 17 April 2019
... further found that ATP concentration is not necessarily an indicator of metabolic activity, as there is no clear correlation between ATP level and growth rates. During fission yeast meiosis, we found a reduction in ATP levels, suggesting that ATP homeostasis is controlled by differentiation. The use of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs218099.
Published: 22 November 2018
...Julia Uraji; Kathleen Scheffler; Melina Schuh ABSTRACT Gametes undergo a specialized and reductional cell division termed meiosis. Female gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the fertilizable egg, while the second meiotic division occurs upon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs222364.
Published: 24 October 2018
... activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II . J. Cell Biol.   206 , 843 - 853 . 10.1083/jcb.201406033 Alvarez-Fernandez , M. , Sanchez-Martinez , R. , Sanz-Castillo , B. , Gan , P. P. , Sanz-Flores , M. , Trakala , M. , Ruiz-Torres , M. , Lorca...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217125.
Published: 03 September 2018
... Lysine 119 (H2AK119ub) and promotes deposition of PRC2-mediated H3K27me3 during meiosis. In postmeiotic spermatids, SCML2 is required for heterochromatin organization, and the loss of SCML2 leads to the formation of ectopic patches of facultative heterochromatin. Our data suggest that, in the absence of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214924.
Published: 06 July 2018
... original work is properly attributed. Summary: Cohesin methylation is a novel post-translational modification implicated in DNA repair in the fission yeast S. pombe . Cohesin DNA repair Mitosis Meiosis Schizosaccharomyces pombe Homologous recombination is an important pathway...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs212100.
Published: 11 June 2018
... regulation of chromosome cohesion throughout meiosis is critical for preventing formation of aneuploid gametes, which are associated with trisomies and infertility in humans. Studying cohesion in meiocytes is complicated by their difficult experimental amenability and the absence of cohesin turnover. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs214411.
Published: 20 March 2018
... damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. By analyzing chromosome dynamics in H2afx −/− spermatocytes, we found that the synapsis of autosomes and X-Y chromosomes was impaired in a fraction of cells. Such defects correlated...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (5): jcs212548.
Published: 06 March 2018
... males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by super-resolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC in...
Includes: Supplementary data