... . 10.1083/jcb.200807195 Sahai , E. ( 2005 ). Mechanisms of cancer cell invasion . Curr. Opin. Genet. Dev. 15 , 87 - 96 . 10.1016/j.gde.2004.12.002 Saraswathibhatla , A. , Indana , D. and Chaudhuri , O. ( 2023 ). Cell–extracellular matrix mechanotransduction in 3D...

... to compress cells in vitro . Mechanobiology Mechanotransduction Membrane Cytoskeleton In vitro systems Mechanosensation Juan de La Cierva JDC2023-051559-I Spanish Ministry of Science and Innovation http://dx.doi.org/10.13039/501100004837 PID2022-142672NB-I00...

...Julien Morival; Anna Hazelwood; Jan Lammerding ABSTRACT The ability of cells to sense and respond to mechanical signals is essential for many biological processes that form the basis of cell identity, tissue development and maintenance. This process, known as mechanotransduction, involves crucial...

...Jonathan Townson; Cinzia Progida ABSTRACT Cells are continuously subjected to physical and chemical cues from the extracellular environment, and sense and respond to mechanical cues via mechanosensation and mechanotransduction. Although the role of the cytoskeleton in these processes is well known...

... for how mechanotransduction and metabolism are linked to include a connection to vasodilation, thereby providing new insight into how diseases involving contractile, metabolic and vasodilatory disturbances arise. For immunoprecipitation of VE-cadherin, cells were lysed in 1× RIPA (50 mM Tris-HCl pH 7.6...

... adhesion. Microscopy Junctions Zonula adherens Intercalated disc Optogenetics Super-resolution Volume electron microscopy Mechanotransduction Adhesion Nederlandse Organisatie voor Wetenschappelijk Onderzoek http://dx.doi.org/10.13039/501100003246 OCENW.KLEIN.281 ZonMw...

... in mechanosensing can vary greatly. Recent studies have also identified mechanosensing behaviors that can be regulated independently of applied force. This important finding has major implications for our understanding of downstream mechanotransduction, the process by which mechanical signals are converted...

...Ignasi Granero-Moya; Valeria Venturini; Guillaume Belthier; Bart Groenen; Marc Molina-Jordán; Miguel González-Martín; Xavier Trepat; Jacco van Rheenen; Ion Andreu; Pere Roca-Cusachs ABSTRACT Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes...

...Emmet A. Francis; Padmini Rangamani ABSTRACT Mechanotransduction, which is the integration of mechanical signals from the external environment of a cell to changes in intracellular signaling, governs many cellular functions. Recent studies have shown that the mechanical state of the cell is also...

... ). Together, these findings suggest that SETD3 is a mechanoresponsive enzyme that regulates mitochondrial dynamics and function by aiding in F-actin polymerization around mitochondria in response to mechanotransduction ( Fig. 7 ). Fig. 7. Proposed model linking SETD3 to mitochondrial dynamics...

... mechanotransductive feedback mechanism that finely tunes YAP activity throughout the process of sprouting angiogenesis. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: Kairbaan Hodivala-Dilke Competing interests...

... , A. , Trepat , X. and Roca-Cusachs , P. ( 2018 ). Control of mechanotransduction by molecular clutch dynamics . Trends Cell Biol. 28 , 356 - 367 . 10.1016/j.tcb.2018.01.008 Espina , J. A. , Marchant , C. L. and Barriga , E. H. ( 2022 ). Durotaxis: the mechanical control...

... ; Zaidel-Bar et al., 2007 ) and are also non-covalently linked to actin stress fibers, which mediate actomyosin contraction, generate intracellular tension and reinforce FA maturation and stabilization. ECM–integrin interactions with FCs and FAs ultimately control mechanotransduction to the nucleus...

... modulates ligand binding to control focal adhesion morphology and tumorigenicity in cancer cells. Vinculin Mechanotransduction Cell–cell adhesion Cell–matrix adhesion National Institutes of Health R35GM136291 T32GM144636-01 P30CA086862 University of Iowa http://dx.doi.org...

.... Summary: Disturbed flow is a key factor in promoting endothelial dysfunction. Frizzled-4 mediates the pro-inflammatory and barrier-disrupting effects of disturbed flow in endothelial cells via a WNT5A- and β-catenin-dependent mechanism. Mechanotransduction Inflammation Orbital shaker...

...Ziyi Feng; Zhenfeng Mao; Ziwei Yang; Xiaowei Liu; Fumihiko Nakamura ABSTRACT Filamin A (FLNA) is an actin crosslinking protein that mediates mechanotransduction. External and internal mechanical forces, through the actin cytoskeleton, can induce conformational changes of the FLNA molecule to expose...

.... ( 2019 ). Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance . Cancer Cell 35 , 347 - 367 . 10.1016/j.ccell.2019.01.007 Craig , D. , Krammer , A. , Schulten , K. and Vogel , V. ( 2001 ). Comparison of the early...

... calibration of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048...

... attributed. Summary: Talin contains 13 force-dependent binary switches; this Cell at a Glance paper describes talin as a memory molecule where these switches confer molecular memory and information-processing functions. Integrin Mechanobiology Mechanomemory Mechanotransduction Memory...

.... 58 , 114 - 119 . 10.1016/j.ceb.2019.02.012 Jahed , Z. , Shams , H. , Mehrbod , M. and Mofrad , M. R. K. ( 2014 ). Mechanotransduction pathways linking the extracellular matrix to the nucleus . Int. Rev. Cell Mol. Biol. 310 , 171 - 220 . 10.1016/B978-0-12-800180...