...Jonathan Townson; Cinzia Progida ABSTRACT Cells are continuously subjected to physical and chemical cues from the extracellular environment, and sense and respond to mechanical cues via mechanosensation and mechanotransduction. Although the role of the cytoskeleton in these processes is well known...

... in mechanosensing can vary greatly. Recent studies have also identified mechanosensing behaviors that can be regulated independently of applied force. This important finding has major implications for our understanding of downstream mechanotransduction, the process by which mechanical signals are converted...

...Aashli Pathni; Kaustubh Wagh; Ivan Rey-Suarez; Arpita Upadhyaya ABSTRACT Mechanosensing, or how cells sense and respond to the physical environment, is crucial for many aspects of biological function, ranging from cell movement during development to cancer metastasis, the immune response and gene...

... signaling in endothelial cells. This might have implications for pathologies involving extracellular matrix stiffening, such as tumor growth. Substrate stiffness Mechanosensing Endothelial cells Notch1 Dll4 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659...

... upregulated in pancreatic cancer cells on soft substrates, due to a lack of integrin engagement. Furthermore, the expression of collagen VI is inversely correlated with mechanosensing and activity of YAP (also known as YAP1), which might be due to a direct or indirect effect on transcription of genes encoding...

.... , Abbas , A. , Majkut , S. , Vogel , K. , Xia , Y. , Ivanovska , I. L. , Irianto , J. , Tewari , M. , Zhu , K. et al. ( 2019 ). Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest . Dev. Cell 49 , 920 - 935.e5 . 10.1016...

... been described as being involved in mechanosensing. Intracellular organelles, including the nucleus ( Aureille et al., 2017 ; Kirby and Lammerding, 2018 ; Lomakin et al., 2020 ; Uhler and Shivashankar, 2017 ; Venturini et al., 2020 ), endoplasmic reticulum (ER) ( Kim et al., 2015 ), mitochondria...

... in the response to EGFR inhibitors owing to crosstalk with mechanosensing integrins, and this may in part account for some of the disappointing results with the clinical use of EGFR inhibitors ( An et al., 2018 ; Záhonero and Sanchez-Gómez, 2014 ). In the body, transmigrating and metastatic tumor cells...

... force generation and mechanosensing activity of human macrophage podosomes . Nat. Commun.   5 , 5343 . 10.1038/ncomms6343 Lee , S. E. , Kamm , R. D. and Mofrad , M. R. K. ( 2007 ). Force-induced activation of Talin and its possible role in focal adhesion mechanotransduction...

... , L. , Määttä , J. A. , Bastmeyer , M. , Hytönen , V. P. , et al. ( 2014 ). Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing . J. Cell Biol.   205 , 265 - 281 . 10.1083/jcb.201308136 Plotnikov , S. V. , Sabass...

... ANR-15-IDEX-01 Fondation ARC pour la Recherche sur le Cancer 10.13039/501100004097 R15124AA Seventh Framework Programme 10.13039/100011102 276945 Cell stretching Mechanosensing Integrins Tools LEGO ® bricks Summary: Here, we report a simple LEGO ®...

...Carolina Diaz; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Dimitris Missirlis ABSTRACT The major fibronectin (FN)-binding α 5 β 1 and α v β 3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved...

.... They mediate numerous functions, including cell–matrix adhesion, extracellular matrix degradation, mechanosensing and cell migration. Podosomes present as micron-sized F-actin cores surrounded by an adhesive ring of integrins and integrin–actin linkers, such as talin and vinculin. In this Review, we highlight...

... experiments and furthermore observed a functionally similar, although kinetically different, response for MRTF-A. Our work thus expands the regulatory impact of VE-cadherins on endothelial mechanosensing to affecting the MRTF–SRF axis. Of note, the involvement of cadherin family proteins in the regulation...

... the expression of frizzled-1, thus promoting signaling and proliferation downstream of Wnt3a in mammary epithelial cells. Mechanosensing Morphogenesis Morphodynamics Mechanotransduction Compliance National Institutes of Health HL110335 HL118532 HL120142 CA187692 CA214292...

... residues within NEDD9. This in turn reduced post-translational cleavage of NEDD9, which we show inhibits NEDD9-induced migration. Collectively, our data therefore suggest that the p130Cas FAT domain uniquely confers a mechanosensing function. References Arold , S. T. , Hoellerer , M. K...

... of the environment. This Commentary reviews how bio-functionalized substrates can be used to analyze how cells sense and interact with their environment. Biomimetic interface Environmental sensing In vitro culture Mechanobiology Mechanosensing Microniches Environment sensing and signaling...

[email protected] ) © 2012. Published by The Company of Biologists Ltd 2012 Atomic force microscopy AFM Cell adhesion Cell surface Cell imaging Mechanosensing Microscopy Single molecule Proteins located on the cell surface have pivotal roles in adhesion, sensing of the environment, signaling...

... biochemical reactions that are triggered by these binding events and by the direct biochemical consequences of genetically encoded information. Cell mechanics Matrix stiffness Mechanosensing © 2011. 2011 * Author for correspondence ( [email protected] ) Reduced stiffness...

... Limited 2009 2009 Mechanosensing Stress fibers Zyxin α-actinin Actomyosin contractility Laser nanosurgery Correlative microscopy Viscoelasticity Mechanotransduction, or the mechanism by which cells convert mechanical stimuli into biochemical signals, is an essential element of many...