... but not to cell density, unlike YAP. Mechanotransduction Sensor Mechanobiology Cell nucleus ‘la Caixa’ Foundation LCF/PR/HR20/52400004 LCF/BQ/DR19/11740009 LCF/BQ/DR19/11740009 Spanish Ministry of Science and Innovation http://dx.doi.org/10.13039/501100004837 PID2022-142672NB...

... of Biologists Ltd 2024 https://www.biologists.com/user-licence-1-1/ Highlighted Article: N-terminal tags impair some functions of lamin A but not others, cautioning researchers who use tagged lamins to study the nucleus. Nucleus Lamin Fluorescent tags Emerin GFP Mechanobiology...

... myosin activity to generate increased pressure in the back compartment that drives the nucleus through the constriction. Nucleus Confined migration Invasion Cortex Mechanobiology Pressure National Institutes of Health R01 HL082792 R01 CA 221346 U54 CA210184 R35 GM153257 R01...

... migration Durotaxis Mechanobiology Cell adhesion Cytoskeleton Mechanotransduction Finnish Cancer Institute https://doi.org/10.13039/100017400 Research Council of Finland https://doi.org/10.13039/501100002341 346131 337530 357910 EMBO https://doi.org/10.13039...

... matrix Mechanobiology Natural Sciences and Engineering Research Council of Canada http://dx.doi.org/10.13039/501100000038 RGPIN-2019-07144 Human Frontier Science Program http://dx.doi.org/10.13039/100004412 RGP0018/2017 Deutsche Forschungsgemeinschaft http...

... of transcription suppress both nuclear bleb formation and stabilization without altering nuclear rigidity, actin compression or actin contraction, suggesting new biophysics for nuclear morphology. Chromatin Mechanobiology Nucleus Nuclear blebbing National Institutes of Health http://dx.doi.org...

... of mechanobiology. From a bottoms-up, physics or engineering point-of-view, such systems are a composition of basic mechanical elements. However, the sheer number and dynamic complexity of them, including active molecular machines and their emergent properties, makes it currently intractable to calculate how...

..., the distinctive cytomechanical and morphodynamic profiles of PSCs are accompanied by a number of unique molecular mechanisms. The extent to which such mechanobiological signatures are intertwined with pluripotency regulation remains an open question that may have important implications in developmental...

...-mediated nuclear expansion, which protects CTCs from shear-induced apoptosis. Fluid shear stress Mechanobiology Circulating tumor cell Histone acetylation Nuclear size National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 11972316 Shenzhen...

.... Published by The Company of Biologists Ltd 2022 Summary: De novo junction formation activates EGFR, which in turn accelerates the formation of subsequent junctions by the same cell. Adherens junctions EGFR signaling, Junction expansion Mechanobiology Mechanobiology Institute...

.... Summary: There are novel antibody epitopes at the actin-binding domain of α-catenin that correlate with high affinity binding and are exposed in junction-stabilizing VE-cadherin–α-catenin fusion proteins. Cadherin Mechanobiology Cell adhesion Endothelial cell junctions Vascular biology...

... attributed. Summary: Talin contains 13 force-dependent binary switches; this Cell at a Glance paper describes talin as a memory molecule where these switches confer molecular memory and information-processing functions. Integrin Mechanobiology Mechanomemory Mechanotransduction Memory...

... function. Centrosome Cilia Cytoskeleton Mechanobiology Organelle assembly Rootlets Medical Research Council http://dx.doi.org/10.13039/501100007155 University of Cambridge http://dx.doi.org/10.13039/501100000735 Isaac Newton Trust http://dx.doi.org/10.13039...

... functions. Mechanobiology GPCR Fluid shear stress Genetically encoded fluorescent reporter Western University of Health Sciences Federal Work-Study NS101384 National Institutes of Health http://dx.doi.org/10.13039/100000002 GM130834 G-protein-coupled...

... expression of lamellipodin promotes cellular stiffness, cyclin expression and cell proliferation in mouse embryonic fibroblasts. ECM stiffness Mechanobiology Proliferation Lamellipodin FAK Rac American Heart Association http://dx.doi.org/10.13039/100000968 18CDA34080415...

... into tumour–microenvironment interactions have led to ideas on targeting it as treatments. Microenvironment Cancer Extracellular matrix Mechanobiology Signalling In tissue biology, the terms stroma or microenvironment have been used to distinguish supporting tissue from the parenchyma...

..., we discuss the mechanisms of megakaryocyte differentiation and how bona fide platelets are brought into circulation. Megakaryocyte Platelet Cytoskeleton Mechanobiology Fondation pour la Recherche Médicale 10.13039/501100002915 ECO20170637508 Institut National de la...

... of Biologists Ltd 2020 Summary: Clathrin-mediated endocytosis can be inhibited by mechanical factors leading to the formation of frustrated clathrin-coated structures that can fulfill new functions. Clathrin Endocytosis Mechanics Mechanobiology Actin Cell signaling Gustave Roussy...

...: The anti-fungal innate immunoreceptor Dectin-1 induces signaling through RHOA, leading to contractile mechanical force generation necessary for phagocytosis. Candida albicans Dectin-1 RHOA Fungal pathogen Mechanobiology National Institutes of Health 10.13039/100000002 P50GM085273...