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Keywords: Mcl-1
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J Cell Sci (2021) 134 (24): jcs258966.
Published: 16 December 2021
... on an apoptosis-primed state to their offspring. This translates into two distinct fates, apoptosis execution post mitosis or cell survival from inefficient apoptosis. Transmitotic resistance is linked to Mcl-1 upregulation and its increased accumulation at mitochondria from mid-S phase onwards, which allows...
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Autophagy
J Cell Sci (2016) 129 (19): 3562–3573.
Published: 1 October 2016
... degradation of a subset of targets while promoting degradation of others. We traced the inhibitory function of TRIM17 to its actions on the anti-autophagy protein Mcl-1, which associates with and inactivates Beclin 1. TRIM17 expression stabilized Mcl-1–Beclin-1 complexes. Despite its ability to inhibit...
Includes: Supplementary data
Journal Articles