...Vinay Kumar Dubey; Souradeep R. Sarkar; Vairavan Lakshmanan; Rimple Dalmeida; Akash Gulyani; Dasaradhi Palakodeti ABSTRACT Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital...

... in presynaptic differentiation remain largely unclear. Here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (MT1-MMP; also known as MMP14) facilitates agrin deposition and signaling during presynaptic development at NMJs. Firstly, agrin deposition along axons...

.... Importantly, we show that osteoclastic bone resorption becomes sensitive to inhibition of matrix metalloproteinases in the presence, but not in the absence, of osteoblast lineage cells. We propose that this may be due to the direct action of osteoblast-lineage-derived MMP-13 on bone resorption...

... extend the repertoire of filamin activities to include control of extracellular matrix (ECM) degradation. We show that knockdown of filamin increases matrix metalloproteinase (MMP) activity and induces MMP2 activation, enhancing the ability of cells to remodel the ECM and increasing their invasive...

...Abdi Ghaffari; Yunyaun Li; Ruhangiz T. Kilani; Aziz Ghahary Matrix metalloproteinases (MMPs) are implicated in the degradation of the extracellular matrix during development and tissue repair, as well as in pathological conditions such as tumor invasion and fibrosis. MMP expression by stromal cells...

... to this work. 2 9 2009 © The Company of Biologists Limited 2009 2009 Cellular invasion ECM degradation Matrix metalloproteinase MMP SNARE To confirm the involvement of syntaxin-13 and SNAP23 in the degradation of the gelatin matrix by HT-1080 cells, these SNAREs were...

.... Herein, we demonstrate that the loss of the VSMC differentiated phenotype, as the repression of contractile-protein expression, is correlated with a dramatic upregulation of the membrane-anchored matrix metalloproteinase MT1-MMP (also known as MMP14 and membrane-type 1 matrix metalloproteinase). Matrix...

... for CD44-dependent TGFβ activation, we next focused on matrix metalloproteinases. Previously, MMP2, MMP9 and MMP14 have been implicated in the activation of TGFβ, and CD44 has been shown to act as a docking molecule for MMP9, localizing MMP9 activity to the cell surface ( Yu and Stamenkovic, 2000...

...Sara A. Illman; Kaisa Lehti; Jorma Keski-Oja; Jouko Lohi Epilysin (MMP-28) is the newest member of the matrix metalloproteinase (MMP) family. Although it is expressed in a number of tissues, no biological substrates or functions for this enzyme have been identified yet. We have expressed...

... of Biologists Limited 2005 2005 Angiogenesis Elastin Matrix metalloproteinase Elastin receptor siRNA Endothelial cell migration assay was performed as previously described ( Vincent et al., 2001 ). Briefly, HMECs (1×10 5 cells/well) were seeded in 24-well plates and grown to confluence...

...Lydia E. Wroblewski; P.-J. M. Noble; Adelina Pagliocca; D. Mark Pritchard; C. Anthony Hart; Fiona Campbell; Andrew R. Dodson; Graham J. Dockray; Andrea Varro Epithelial cell responses to bacterial infection include induction of matrix metalloproteinase 7 (MMP-7). Here, we identify increased MMP-7...