...Vinay Kumar Dubey; Souradeep R. Sarkar; Vairavan Lakshmanan; Rimple Dalmeida; Akash Gulyani; Dasaradhi Palakodeti ABSTRACT Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital...

... in presynaptic differentiation remain largely unclear. Here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (MT1-MMP; also known as MMP14) facilitates agrin deposition and signaling during presynaptic development at NMJs. Firstly, agrin deposition along axons...

.... Importantly, we show that osteoclastic bone resorption becomes sensitive to inhibition of matrix metalloproteinases in the presence, but not in the absence, of osteoblast lineage cells. We propose that this may be due to the direct action of osteoblast-lineage-derived MMP-13 on bone resorption...

... extend the repertoire of filamin activities to include control of extracellular matrix (ECM) degradation. We show that knockdown of filamin increases matrix metalloproteinase (MMP) activity and induces MMP2 activation, enhancing the ability of cells to remodel the ECM and increasing their invasive...

...Abdi Ghaffari; Yunyaun Li; Ruhangiz T. Kilani; Aziz Ghahary Matrix metalloproteinases (MMPs) are implicated in the degradation of the extracellular matrix during development and tissue repair, as well as in pathological conditions such as tumor invasion and fibrosis. MMP expression by stromal cells...

... to this work. 2 9 2009 © The Company of Biologists Limited 2009 2009 Cellular invasion ECM degradation Matrix metalloproteinase MMP SNARE Cellular remodeling of the extracellular matrix (ECM) is essential to physiological processes such as embryogenesis and wound healing...

.... Herein, we demonstrate that the loss of the VSMC differentiated phenotype, as the repression of contractile-protein expression, is correlated with a dramatic upregulation of the membrane-anchored matrix metalloproteinase MT1-MMP (also known as MMP14 and membrane-type 1 matrix metalloproteinase). Matrix...

... for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 4 2 2008 © The Company of Biologists Limited 2008 2008 CD44 Cytoskeleton Fibroblast TGFβ Migration Integrin Matrix metalloproteinase Injury results in inflammation, which...

...Sara A. Illman; Kaisa Lehti; Jorma Keski-Oja; Jouko Lohi Epilysin (MMP-28) is the newest member of the matrix metalloproteinase (MMP) family. Although it is expressed in a number of tissues, no biological substrates or functions for this enzyme have been identified yet. We have expressed...

... of Biologists Limited 2005 2005 Angiogenesis Elastin Matrix metalloproteinase Elastin receptor siRNA Angiogenesis involves the formation of capillaries from preexisting microvessels and therefore contributes to vascular remodeling and maturation ( Carmeliet, 2000 ). It plays a pivotal function...

...Lydia E. Wroblewski; P.-J. M. Noble; Adelina Pagliocca; D. Mark Pritchard; C. Anthony Hart; Fiona Campbell; Andrew R. Dodson; Graham J. Dockray; Andrea Varro Epithelial cell responses to bacterial infection include induction of matrix metalloproteinase 7 (MMP-7). Here, we identify increased MMP-7...

...George E. Davis; Kristine A. Pintar Allen; René Salazar; Steven A. Maxwell ABSTRACT Here, we describe a new function for plasmin and matrix metalloproteinases (MMPs), which is to regulate the regression of capillary tubes in three-dimensional extracellular matrix environments. Using a well...

... ). Changing views of the role of matrix metalloproteinases in metastasis . J. Natl. Cancer Inst . 89 , 1260 – 1270 . Crawford , H. C. , Fingleton , B. M. , Rudolph-Owen , L. A. , Heppner Goss , K. J. , Rubinfeld , B. , Polakis , P. and Matrisian , L. M. ( 1999...

... cells and in most tumors, and it could have similar roles in extracellular matrix remodeling during tumorigenesis and cell invasion. In the present study, we show that α3β1 expression is required in immortalized mouse keratinocytes (MK) for the production of the matrix metalloproteinase MMP-9/gelatinase...

... for correspondence at address 1 (e-mail: [email protected] ) 02 12 1999 14 02 2000 © 2000 by Company of Biologists 2000 Fibronectin Mammary gland Involution Matrix metalloproteinase Extracellular matrix The mature mammary epithelium is composed of three epithelial cell types...

...Nina Johansson; Risto Ala-aho; Veli-Jukka Uitto; Reidar Grénman; Norbert E. Fusenig; Carlos López-OtÍn; Veli-Matti Kähäri ABSTRACT Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by transformed squamous epithelial cells, i.e. squamous cell carcinoma (SCC) cells...

... cultured in the presence of dibutyryl cAMP (Bt2) and hydrocortisone (HC), the deposition of a fibrous lattice of matrix molecules consisting of collagens type IV, type XVIII, laminin and thrombospondin was induced. In basal medium (without Bt2 and HC), HDMEC released active matrix metalloproteinases (MMPs...

... for correspondence (e-mail: [email protected] ) 02 04 1993 18 07 1993 © 1997 by Company of Biologists 1997 Matrix metalloproteinase MMP-2 MT-MMP-1 TIMP-2 Extracellular matrix Integrin Cell migration Cell adhesion The integrity of the extracellular matrix (ECM...

... cysteine proteinases can degrade collagen after the demineralization of bone at low pH, several lines of evidence suggest that collage-nase (matrix metalloproteinase-1, EC 3.4.24.7) may also be involved in this process. The question of whether col-lagenase is present in the osteoclast and/or in the bone...

...Hideto Watanabe; Isao Nakanishi; Kyoko Yamashita; Taro Hayakawa; Yasunori Okada ABSTRACT The role of matrix metalloproteinase-9 (MMP-9, 92 kDa gelatinase/type IV collagenase) in invasion of mononuclear phagocytes was studied with U937 monoblastoid cells. 12- o -tetradecanoyl 13-phorbol acetate (TPA...