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Keywords: Matrix assemblyClose
J Cell Sci (2008) 121 (15): 2452–2462.
Published: 01 August 2008
... Adhesion Cytoskeleton Extracellular matrix Rho Matrix assembly Integrins consist of non-covalently linked α- and β-subunits. Ligands, including extracellular matrix (ECM) components such as fibronectin, are bound to the integrin extracellular globular head domain whereas a multitude...
Includes: Supplementary data
J Cell Sci (2005) 118 (19): 4427–4436.
Published: 01 October 2005
... culture. In most situations in vivo, however, matrix assembly occurs within existing three-dimensional (3D) extracellular matrix networks. In an attempt to mimic this environment, we analyzed matrix assembly by fibroblasts cultured on a pre-assembled 3D fibronectin matrix and found significant stimulation...
Katherine Clark, Roumen Pankov, Mark A. Travis, Janet A. Askari, A. Paul Mould, Susan E. Craig, Peter Newham, Kenneth M. Yamada, Martin J. Humphries
J Cell Sci (2005) 118 (2): 291–300.
Published: 15 January 2005
... induced directional translocation of α 5 β 1 , mimicking fibrillar adhesion formation. Priming of α 5 β 1 integrin by SNAKA51 increased the accumulation of detergent-resistant fibronectin in the extracellular matrix, thus identifying an integrin conformation that promotes matrix assembly. The SNAKA51...
J Cell Sci (2002) 115 (6): 1221–1229.
Published: 15 March 2002
..., and the actin-binding domain of moesin fused to cyan fluorescent protein (cfp-Moe) to stain actin. Actin filament bundles were clearly seen in the protruding lamellae of the cells. FN matrix assembly appeared to be initiated as small spots of FN at the ends of actin filament bundles. The spots then elongated...
Includes: Multimedia, Supplementary data