...Amnon Buxboim; Irena L. Ivanovska; Dennis E. Discher Cellular organization within a multicellular organism requires that a cell assess its relative location, taking in multiple cues from its microenvironment. Given that the extracellular matrix (ECM) consists of the most abundant proteins...

... culture substrates show a progressive loss of rhythmic beating. Here, isolated embryonic cardiomyocytes cultured on a series of flexible substrates show that matrices that mimic the elasticity of the developing myocardial microenvironment are optimal for transmitting contractile work to the matrix...

... to a protein complex that can trigger the formation of hemidesmosomes, certain cell-matrix attachment sites found in epithelial cells. We have prepared a monoclonal antibody (12C4) whose epitope is located toward the carboxy terminus of the globular domain of the α3 laminin subunit. This epitope is lost from...

...Scott E. Baker; Susan B. Hopkinson; Mark Fitchmun; Grai L. Andreason; Francine Frasier; George Plopper; Vito Quaranta; Jonathan C. R. Jones ABSTRACT Hemidesmosomes are complex macromolecular structures which integrate elements of the extracellular matrix and the cytoskeleton of epithelial cells...

...D. S. Grant; J. L. Kinsella; M. C. Kibbey; S. LaFlamme; P. D. Burbelo; A. L. Goldstein; H. K. Kleinman ABSTRACT We performed differential cDNA hybridization using RNA from endothelial cells cultured for 4 hours on either plastic or basement membrane matrix (Matrigel), and identified early genes...

... Biology and Genetics, The Rockefeller University, New York, USA ‡ Present address: Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA 03 05 1995 09 05 1995 © 1995 by Company of Biologists 1995 nuclear domain matrix steroid receptor...