... micelles. To test the feasibility of the latter mechanism, we developed a mathematical model that describes the formation of lipid microdomains in the canalicular membrane. Bile salt monomers intercalate into the external hemileaflet of the canalicular membrane, to form a rim to liquid disordered domain...

...-in activation regulates integrin turnover to stabilize tissue architecture in vivo . Treating Drosophila embryos with Mg 2+ and Mn 2+ , known to induce outside-in activation, resulted in decreased integrin turnover. Mathematical modeling combined with mutational analysis provides mechanistic insight...

... role of RCAN1 in the calcineurin–NFAT signaling pathway, is promoted by PI3K signaling. Based on this, along with integrated information from previous experiments, we developed a mathematical model in which the functional role of RCAN1 changes in a dose-dependent manner: RCAN1 functions as an inhibitor...

... ERK can inactivate RKIP. The aim of this study was to elucidate the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and in silico simulations based on an experimentally validated mathematical model. We show...

... for correspondence (e-mail: [email protected] ) 6 6 2006 © The Company of Biologists Limited 2006 2006 Computational modeling Mathematical modeling Oxygen sensing Hypoxic response The transcription factor HIF (hypoxia-inducible factor) plays a crucial role in mammalian response to oxygen...