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1-20 of 30
Keywords: Mammary gland
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Journal Articles
Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation
Open AccessIn collection:
Cell migration
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (1): jcs259275.
Published: 5 January 2023
... Branching morphogenesis Epithelial development Mammary gland TGF-β National Institutes of Health http://dx.doi.org/10.13039/100000002 NIGMS 3T32GM007309 U54CA268083 National Science Foundation http://dx.doi.org/10.13039/100000001 1915491 Breast Cancer Research...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (22): jcs258905.
Published: 23 November 2021
.... These results highlight the importance of the concerted action of extracellular syntaxin4 extruded in response to the lactogenic hormone and BM components in epithelial morphogenesis. Fig. 1. Effect of syntaxin4 on 3D morphogenesis of mammary gland epithelia. (A) Left upper: schematic diagrams of a tip...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
Teneale A. Stewart, Katherine Hughes, Alexander J. Stevenson, Natascia Marino, Adler L. Ju, Michael Morehead, Felicity M. Davis
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (1): jcs248849.
Published: 8 January 2021
...-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival. References Árnadóttir , J. and Chalfie , M. ( 2010...
Includes: Supplementary data
Journal Articles
Emilie Lagoutte, Clémentine Villeneuve, Vincent Fraisier, Denis Krndija, Marie-Ange Deugnier, Philippe Chavrier, Carine Rossé
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (12): jcs242495.
Published: 23 June 2020
... in vivo . The adult mammary gland provides a unique model for investigating physiological or pathological processes such as morphogenesis or epithelial cell dissemination. Here, we establish a new pipeline to study rare cellular events occurring in the mammary gland, by combining orthotopic...
Includes: Supplementary data
Journal Articles
Andrew J. Ewald, Robert J. Huebner, Hildur Palsdottir, Jessie K. Lee, Melissa J. Perez, Danielle M. Jorgens, Andrew N. Tauscher, Kevin J. Cheung, Zena Werb, Manfred Auer
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (11): 2638–2654.
Published: 1 June 2012
.... ( 1997 ). Three division-competent, structurally-distinct cell populations contribute to murine mammary epithelial renewal . Tissue Cell 29 , 239 - 253 . Chepko G. , Smith G. H. ( 1999 ). Mammary epithelial stem cells: our current understanding . J. Mammary Gland Biol. Neoplasia...
Includes: Multimedia, Supplementary data
Journal Articles
In collection:
Lipid biology
Tanya D. Russell, Jerome Schaack, David J. Orlicky, Carol Palmer, Benny Hung-Junn Chang, Lawrence Chan, James L. McManaman
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (19): 3247–3253.
Published: 1 October 2011
... family of CLD binding proteins, is hypothesized to regulate CLD production in these cells during differentiation of the mammary gland into a secretory organ. We tested this hypothesis by comparing CLD accumulation in differentiating mammary glands of wild-type and ADPH-deficient mice. ADPH deficiency did...
Journal Articles
Jacqueline Whyte, Laura Thornton, Sara McNally, Sarah McCarthy, Fiona Lanigan, William M. Gallagher, Torsten Stein, Finian Martin
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (19): 3316–3328.
Published: 1 October 2010
... on sections cut from PBS-buffered formalin-fixed and paraffin-embedded inguinal mammary glands. In brief, after de-waxing in xylene, antigen retrieval was performed using 1 mM EDTA, pH 9.0 in a pressure cooker. The sections were blocked for 30 minutes in Image-iT FX Signal Enhancer solution (Invitrogen...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (4): 606–618.
Published: 15 February 2010
...Stephanie B. Greene; Preethi H. Gunaratne; Scott M. Hammond; Jeffrey M. Rosen In an effort to understand the potential role of microRNAs (miRNAs) in mammary-gland stem or progenitor cells, miRNA microarrays were performed on subpopulations of the mouse mammary epithelial cell (MEC) line COMMA-DβGeo...
Includes: Supplementary data
Journal Articles
Mercy S. Chen, Wendy A. Woodward, Fariba Behbod, Sirisha Peddibhotla, Maria P. Alfaro, Thomas A. Buchholz, Jeffrey M. Rosen
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (3): 468–477.
Published: 1 February 2007
... Mammary gland Stem Progenitor Cell line COMMA-D β-geo Sca1 Breast epithelium is capable of completely and functionally regenerating upon transplantation. This impressive renewal capacity has been ascribed to the function of a multipotent mammary gland stem/progenitor cell population...
Journal Articles
Cathepsin D released by lactating rat mammary epithelial cells is involved in prolactin cleavage under physiological conditions
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (21): 5155–5164.
Published: 1 October 2004
...Mustapha Lkhider; Roberta Castino; Edwige Bouguyon; Ciro Isidoro; Michèle Ollivier-Bousquet The 16 kDa prolactin fragment arises from partial proteolysis of the native 23 kDa prolactin pituitary hormone. The mammary gland has been involved in this processing, although it has not been clarified...
Journal Articles
A β-catenin survival signal is required for normal lobular development in the mammary gland
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (6): 1137–1149.
Published: 15 March 2003
...Stacey B. Tepera; Pierre D. McCrea; Jeffrey M. Rosen The Wnt (wingless) family of secreted glycoproteins initiates a signalling pathway implicated in the regulation of both normal mouse mammary gland development and tumorigenesis. Multiple Wnt signals ultimately converge on the multifunctional...
Journal Articles
Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (4): 675–682.
Published: 15 February 2003
...-binding proteins (IGFBPs),there is currently no experimental evidence that IGFBPs regulate the survival function of IGFs in the mammary gland. We have examined IGFBP expression during mammary gland development and studied the effects of IGFBPs on IGF-mediated survival and signalling in mammary epithelial...
Journal Articles
Retinoids induce lumen morphogenesis in mammary epithelial cells
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (23): 4419–4431.
Published: 1 December 2002
... inhibitor BB94,indicating that this morphogenetic process is likely to require MMP activity. Collectively, our results provide evidence that RA promotes lumen formation by mammary epithelial cells in vitro and suggest that it plays a similar role during mammary gland development in vivo. Fig. 5. When...
Journal Articles
Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase
Available to PurchaseNadia Munarini, Richard Jäger, Susanne Abderhalden, Gisela Zuercher, Valeria Rohrbach, Saemi Loercher, Brigitte Pfanner-Meyer, Anne-Catherine Andres, Andrew Ziemiecki
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (1): 25–37.
Published: 1 January 2002
... gland. To investigate its role in the biology of the mammary gland, we have established transgenic mice bearing the EphB4 receptor under the control of the MMTV-LTR promoter, which represents the first transgenic mouse model to investigate the effect(s) of unscheduled expression of EphB4 in adult...
Journal Articles
CD44 expression and regulation during mammary gland development and function
Available to PurchaseLionel Hebbard, Anja Steffen, Volker Zawadzki, Christina Fieber, Norma Howells, Jürgen Moll, Helmut Ponta, Martin Hofmann, Jonathan Sleeman
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (14): 2619–2630.
Published: 15 July 2000
... function in mammary tumors and mammary glands is unknown. To begin to resolve these issues, we analysed in detail the normal postnatal expression patterns and regulation of the CD44v6 epitope in murine mammary glands. We demonstrate that significant CD44v6 epitope expression is first seen during puberty...
Journal Articles
Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium
Available to PurchaseStuart Naylor, Matthew J. Smalley, David Robertson, Barry A. Gusterson, Paul A. W. Edwards, Trevor C. Dale
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (12): 2129–2138.
Published: 15 June 2000
...Stuart Naylor; Matthew J. Smalley; David Robertson; Barry A. Gusterson; Paul A. W. Edwards; Trevor C. Dale ABSTRACT Several Wnt genes are expressed in the postnatal mouse mammary gland and are thought to be involved in mammary gland development. Ectopic expression of Wnt-1, which is not normally...
Journal Articles
Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (5): 849–858.
Published: 1 March 2000
... expression Epithelial-mesenchymal interaction Mammary gland Tissue-specific gene expression in epithelial cells is achieved through integration of multiple and sustained signals from the cellular microenvironment. Mouse mammary epithelial cells isolated from mid-pregnant mammary glands form acinus...
Journal Articles
Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (5): 795–806.
Published: 1 March 2000
...P. Schedin; R. Strange; T. Mitrenga; P. Wolfe; M. Kaeck ABSTRACT Mammary gland form and function are regulated by interactions between epithelium and extracellular matrix. Major glycoprotein components of extracellular matrix have been identified that give survival, proliferation...
Journal Articles
α S1 -casein is required for the efficient transport of β- and κ-casein from the endoplasmic reticulum to the Golgi apparatus of mammary epithelial cells
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (19): 3399–3412.
Published: 1 October 1999
... of goats bearing alleles associated with a reduced α S1 -Cn content in milk affected the Cns but not the main whey proteins. Fig. 2. Immunofluorescence localisation of lactoproteins in mammary acini of goat homozygous for distinct α S1 -Cn alleles. Fragments of the mammary gland of α S1 -CnA...
Journal Articles
Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland
Available to PurchaseAnthony D. Metcalfe, Andrew Gilmore, Teresa Klinowska, Janine Oliver, Anthony J. Valentijn, Robin Brown, Andrea Ross, Grant MacGregor, John A. Hickman, Charles H. Streuli
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (11): 1771–1783.
Published: 1 June 1999
...Anthony D. Metcalfe; Andrew Gilmore; Teresa Klinowska; Janine Oliver; Anthony J. Valentijn; Robin Brown; Andrea Ross; Grant MacGregor; John A. Hickman; Charles H. Streuli ABSTRACT Epithelial cells within the mammary gland undergo developmental programmes of proliferation and apoptosis during...
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