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Keywords: Mammary gland
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Journal Articles
In collection:
Cell migration
J Cell Sci (2023) 136 (1): jcs259275.
Published: 5 January 2023
... Branching morphogenesis Epithelial development Mammary gland TGF-β National Institutes of Health http://dx.doi.org/10.13039/100000002 NIGMS 3T32GM007309 U54CA268083 National Science Foundation http://dx.doi.org/10.13039/100000001 1915491 Breast Cancer Research...
Includes: Supplementary data
Journal Articles
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Polarity
J Cell Sci (2021) 134 (22): jcs258905.
Published: 23 November 2021
.... These results highlight the importance of the concerted action of extracellular syntaxin4 extruded in response to the lactogenic hormone and BM components in epithelial morphogenesis. Fig. 1. Effect of syntaxin4 on 3D morphogenesis of mammary gland epithelia. (A) Left upper: schematic diagrams of a tip...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (1): jcs248849.
Published: 8 January 2021
...-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival. References Árnadóttir , J. and Chalfie , M. ( 2010...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs242495.
Published: 23 June 2020
... in vivo . The adult mammary gland provides a unique model for investigating physiological or pathological processes such as morphogenesis or epithelial cell dissemination. Here, we establish a new pipeline to study rare cellular events occurring in the mammary gland, by combining orthotopic...
Includes: Supplementary data
Journal Articles
Journal Articles
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Lipid biology
J Cell Sci (2011) 124 (19): 3247–3253.
Published: 1 October 2011
... family of CLD binding proteins, is hypothesized to regulate CLD production in these cells during differentiation of the mammary gland into a secretory organ. We tested this hypothesis by comparing CLD accumulation in differentiating mammary glands of wild-type and ADPH-deficient mice. ADPH deficiency did...
Journal Articles
J Cell Sci (2010) 123 (19): 3316–3328.
Published: 1 October 2010
... on sections cut from PBS-buffered formalin-fixed and paraffin-embedded inguinal mammary glands. In brief, after de-waxing in xylene, antigen retrieval was performed using 1 mM EDTA, pH 9.0 in a pressure cooker. The sections were blocked for 30 minutes in Image-iT FX Signal Enhancer solution (Invitrogen...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 606–618.
Published: 15 February 2010
...Stephanie B. Greene; Preethi H. Gunaratne; Scott M. Hammond; Jeffrey M. Rosen In an effort to understand the potential role of microRNAs (miRNAs) in mammary-gland stem or progenitor cells, miRNA microarrays were performed on subpopulations of the mouse mammary epithelial cell (MEC) line COMMA-DβGeo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 468–477.
Published: 1 February 2007
... Mammary gland Stem Progenitor Cell line COMMA-D β-geo Sca1 Breast epithelium is capable of completely and functionally regenerating upon transplantation. This impressive renewal capacity has been ascribed to the function of a multipotent mammary gland stem/progenitor cell population...
Journal Articles
J Cell Sci (2004) 117 (21): 5155–5164.
Published: 1 October 2004
...Mustapha Lkhider; Roberta Castino; Edwige Bouguyon; Ciro Isidoro; Michèle Ollivier-Bousquet The 16 kDa prolactin fragment arises from partial proteolysis of the native 23 kDa prolactin pituitary hormone. The mammary gland has been involved in this processing, although it has not been clarified...
Journal Articles
J Cell Sci (2003) 116 (6): 1137–1149.
Published: 15 March 2003
...Stacey B. Tepera; Pierre D. McCrea; Jeffrey M. Rosen The Wnt (wingless) family of secreted glycoproteins initiates a signalling pathway implicated in the regulation of both normal mouse mammary gland development and tumorigenesis. Multiple Wnt signals ultimately converge on the multifunctional...
Journal Articles
J Cell Sci (2003) 116 (4): 675–682.
Published: 15 February 2003
...-binding proteins (IGFBPs),there is currently no experimental evidence that IGFBPs regulate the survival function of IGFs in the mammary gland. We have examined IGFBP expression during mammary gland development and studied the effects of IGFBPs on IGF-mediated survival and signalling in mammary epithelial...
Journal Articles
J Cell Sci (2002) 115 (23): 4419–4431.
Published: 1 December 2002
... inhibitor BB94,indicating that this morphogenetic process is likely to require MMP activity. Collectively, our results provide evidence that RA promotes lumen formation by mammary epithelial cells in vitro and suggest that it plays a similar role during mammary gland development in vivo. Fig. 5. When...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (14): 2619–2630.
Published: 15 July 2000
... function in mammary tumors and mammary glands is unknown. To begin to resolve these issues, we analysed in detail the normal postnatal expression patterns and regulation of the CD44v6 epitope in murine mammary glands. We demonstrate that significant CD44v6 epitope expression is first seen during puberty...
Journal Articles
J Cell Sci (2000) 113 (12): 2129–2138.
Published: 15 June 2000
...Stuart Naylor; Matthew J. Smalley; David Robertson; Barry A. Gusterson; Paul A. W. Edwards; Trevor C. Dale ABSTRACT Several Wnt genes are expressed in the postnatal mouse mammary gland and are thought to be involved in mammary gland development. Ectopic expression of Wnt-1, which is not normally...
Journal Articles
J Cell Sci (2000) 113 (5): 849–858.
Published: 1 March 2000
... expression Epithelial-mesenchymal interaction Mammary gland Tissue-specific gene expression in epithelial cells is achieved through integration of multiple and sustained signals from the cellular microenvironment. Mouse mammary epithelial cells isolated from mid-pregnant mammary glands form acinus...
Journal Articles
J Cell Sci (2000) 113 (5): 795–806.
Published: 1 March 2000
...P. Schedin; R. Strange; T. Mitrenga; P. Wolfe; M. Kaeck ABSTRACT Mammary gland form and function are regulated by interactions between epithelium and extracellular matrix. Major glycoprotein components of extracellular matrix have been identified that give survival, proliferation...
Journal Articles
Journal Articles
J Cell Sci (1999) 112 (11): 1771–1783.
Published: 1 June 1999
...Anthony D. Metcalfe; Andrew Gilmore; Teresa Klinowska; Janine Oliver; Anthony J. Valentijn; Robin Brown; Andrea Ross; Grant MacGregor; John A. Hickman; Charles H. Streuli ABSTRACT Epithelial cells within the mammary gland undergo developmental programmes of proliferation and apoptosis during...