.... Collective cell migration Bifurcation Branching morphogenesis Epithelial development Mammary gland TGF-β National Institutes of Health http://dx.doi.org/10.13039/100000002 NIGMS 3T32GM007309 U54CA268083 National Science Foundation http://dx.doi.org/10.13039/100000001 1915491...

... acts coordinately with basement membrane components to trigger mammary cyst formation. Mammary gland Syntaxin4 Epithelial morphogenesis Epimorphin Basement membrane Epithelial–mesenchymal transition Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691...

...-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival. * Author for correspondence ( f.davis@uq.edu.au ) Handling Editor...

... in vivo . The adult mammary gland provides a unique model for investigating physiological or pathological processes such as morphogenesis or epithelial cell dissemination. Here, we establish a new pipeline to study rare cellular events occurring in the mammary gland, by combining orthotopic...

..., rather than individual thin projections. Because we observed similar membrane protrusions on interior cells in TEBs from normal mammary glands, we conclude that these structures are transiently produced both in vivo and in vitro during normal mammary morphogenesis. These 3D membrane extensions increase...

... family of CLD binding proteins, is hypothesized to regulate CLD production in these cells during differentiation of the mammary gland into a secretory organ. We tested this hypothesis by comparing CLD accumulation in differentiating mammary glands of wild-type and ADPH-deficient mice. ADPH deficiency did...

... Mammary gland Epithelial Cell polarity PKCζ Proliferation Breast cancer Mammary epithelial cells (MECs) form acini when cultured on laminin-rich extracellular matrix (ECM) in vitro. Acini are reminiscent of epithelial cysts seen in the mammary gland in vivo; the constituent cells...

...Stephanie B. Greene; Preethi H. Gunaratne; Scott M. Hammond; Jeffrey M. Rosen In an effort to understand the potential role of microRNAs (miRNAs) in mammary-gland stem or progenitor cells, miRNA microarrays were performed on subpopulations of the mouse mammary epithelial cell (MEC) line COMMA-DβGeo...

... Mammary gland Stem Progenitor Cell line COMMA-D β-geo Sca1 Breast epithelium is capable of completely and functionally regenerating upon transplantation. This impressive renewal capacity has been ascribed to the function of a multipotent mammary gland stem/progenitor cell population...

...Mustapha Lkhider; Roberta Castino; Edwige Bouguyon; Ciro Isidoro; Michèle Ollivier-Bousquet The 16 kDa prolactin fragment arises from partial proteolysis of the native 23 kDa prolactin pituitary hormone. The mammary gland has been involved in this processing, although it has not been clarified...

...Stacey B. Tepera; Pierre D. McCrea; Jeffrey M. Rosen The Wnt (wingless) family of secreted glycoproteins initiates a signalling pathway implicated in the regulation of both normal mouse mammary gland development and tumorigenesis. Multiple Wnt signals ultimately converge on the multifunctional...

...-binding proteins (IGFBPs),there is currently no experimental evidence that IGFBPs regulate the survival function of IGFs in the mammary gland. We have examined IGFBP expression during mammary gland development and studied the effects of IGFBPs on IGF-mediated survival and signalling in mammary epithelial...

... inhibitor BB94,indicating that this morphogenetic process is likely to require MMP activity. Collectively, our results provide evidence that RA promotes lumen formation by mammary epithelial cells in vitro and suggest that it plays a similar role during mammary gland development in vivo. When grown...

... gland. To investigate its role in the biology of the mammary gland, we have established transgenic mice bearing the EphB4 receptor under the control of the MMTV-LTR promoter, which represents the first transgenic mouse model to investigate the effect(s) of unscheduled expression of EphB4 in adult...

... and human mammary glands. In neoplastic disease the benign, carcinogen-induced rat and benign, human mammary tumours can contain epithelial, myoepithelial-like and alveolar-like cells, whereas their malignant counterparts mainly contain only epithelial-like cells. Clonal epithelial cell lines from normal...

... 10 1986 © 1987 by Company of Biologists 1987 breast cancer epithelial cells mammary gland cathepsin B cysteine proteinases. A secreted form of cathepsin B, cysteine proteinase, has been suggested as playing an important role in the destruction of extracellular matrix...

..., Cambridge, U.K. 28 08 1985 01 07 1985 © 1986 by Company of Biologists 1986 monoclonal antibodies immunofluorescence mammary gland antigenic heterogeneity Adult human mammary epithelium is composed principally of two types of cell, the luminal epithelial cell...

... 1985 © 1985 by Company of Biologists 1985 mammary gland basement membrane intermediate filaments The mammary gland consists of a branching ductal system that is separated from the surrounding stroma by a basement membrane ( Anderson, 1978 ). In the mammary glands of virgin rats...