..., leading to a significantly expedited procedure, and enhanced preservation of specific epitopes. Plasmodium Malaria Expansion microscopy Mitochondria Lysosomes Swiss National Science Foundation http://dx.doi.org/10.13039/501100001711 310030_182465 207525 Malaria...

...David Anaguano; Watcharatip Dedkhad; Carrie F. Brooks; David W. Cobb; Vasant Muralidharan ABSTRACT The malaria-causing parasite, Plasmodium falciparum completely remodels its host red blood cell (RBC) through the export of several hundred parasite proteins, including transmembrane proteins, across...

...Melanie C. Ridgway; Daniela Cihalova; Simon H. J. Brown; Phuong Tran; Todd W. Mitchell; Alexander G. Maier ABSTRACT Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only...

...Manish Goyal; Brajesh Kumar Singh; Karina Simantov; Yotam Kaufman; Shiri Eshar; Ron Dzikowski ABSTRACT Plasmodium falciparum , the parasite responsible for the deadliest form of human malaria, replicates within the erythrocytes of its host, where it encounters numerous pressures that cause...

...Michele S. Y Tan; Michael J. Blackman ABSTRACT All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during...

... requires chromosome replication and precise segregation to ensure daughter cells have identical genomic copies. Species of the genus Plasmodium , the causative agents of malaria, display remarkable aspects of nuclear division throughout their life cycle to meet some peculiar and unique challenges to DNA...

...Catherine A. Moreau; Katharina A. Quadt; Henni Piirainen; Hirdesh Kumar; Saligram P. Bhargav; Léanne Strauss; Niraj H. Tolia; Rebecca C. Wade; Joachim P. Spatz; Inari Kursula; Friedrich Frischknecht ABSTRACT During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium...

... in the vicinity of the food vacuole is important for its function in Plasmodium falciparum . Malaria Plasmodium falciparum GCN5 Histone acetyltransferase Histone acetylation Cysteine protease Protein processing ChIP sequencing ChIP seq Department of Biotechnology, Ministry of Science...

... that the original work is properly attributed. Summary: We newly identify a Plasmodium -specific transmembrane protein of the basal complex termed BTP1. BTP1 dynamics during schizogony correlate with membrane invagination during the final steps of cell division. Malaria Apicomplexa Cell division...

... resistant to artemisinins. Malaria Plasmodium Artemisinin Haemoglobin degradation Falcipains Resistance Malaria is a debilitating parasitic disease caused by protozoan parasites of the genus Plasmodium . Annually, about 200 million new infections of P. falciparum malaria...

...Noa Dahan-Pasternak; Abed Nasereddin; Netanel Kolevzon; Michael Pe'er; Wilson Wong; Vera Shinder; Lynne Turnbull; Cynthia B. Whitchurch; Michael Elbaum; Tim W. Gilberger; Eylon Yavin; Jake Baum; Ron Dzikowski Summary In Plasmodium falciparum , the deadliest form of human malaria, the nuclear...

...Megan K. Dearnley; Jeffrey A. Yeoman; Eric Hanssen; Shannon Kenny; Lynne Turnbull; Cynthia B. Whitchurch; Leann Tilley; Matthew W. A. Dixon The most virulent of the human malaria parasites, Plasmodium falciparum , undergoes a remarkable morphological transformation as it prepares itself for sexual...

...Nurhidanatasha Abu Bakar; Nectarios Klonis; Eric Hanssen; Cherrine Chan; Leann Tilley The digestive vacuole of the malaria parasite Plasmodium falciparum is the site of haemoglobin digestion and haem detoxification, and is the target of chloroquine and other antimalarials. The mechanisms...

...Michelle D. Lazarus; Timothy G. Schneider; Theodore F. Taraschi The current model for hemoglobin ingestion and transport by intraerythrocytic Plasmodium falciparum malaria parasites shares similarities with endocytosis. However, the model is largely hypothetical, and the mechanisms responsible...

...Adele M. Lehane; Rhys Hayward; Kevin J. Saliba; Kiaran Kirk Chloroquine resistance in the malaria parasite Plasmodium falciparum has made malaria increasingly difficult to control. Chloroquine-resistant parasites accumulate less chloroquine than their chloroquine-sensitive counterparts; however...

... yoelii and Plasmodium falciparum sporozoites, which both depend on host CD81 expression for invasion, but not during CD81-independent infection by Plasmodium berghei sporozoites. Our results unravel a functional link between CD81 and cholesterol during infection by malaria parasites, and illustrate...

... increased oxidative susceptibility due to an amino acid substitution (β6: Glu to Lys). The growth of Plasmodium falciparum is abnormal in homozygous CC erythrocytes in vitro, and CC individuals show innate protection against severe P. falciparum malaria. We investigated one possible mechanism of innate...

... ) 13 11 2003 © The Company of Biologists Limited 2004 2004 Malaria Nile Red Neutral lipid Acyl-CoA:diacylglycerol acyltransferase Brefeldin A Fatty acid Plasmodium falciparum is responsible for the most virulent form of malaria, a disease that exerts an enormous toll...

...Akinola Adisa; Frank R. Albano; John Reeder; Michael Foley; Leann Tilley The malaria parasite, Plasmodium falciparum , spends part of its life cycle inside the enucleated erythrocytes of its human host. The parasite modifies the cytoplasm and plasma membrane of its host cell by exporting proteins...

... by Company of Biologists 2000 Anopheles Basal lamina Malaria Midgut Two-hybrid system The ingestion of Plasmodium spp. by the insect vector in an infected blood meal induces a series of important developmental processes in the mosquito midgut that are initiated by the maturation...