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Keywords: Mad1
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Journal Articles
Journal Articles
J Cell Sci (2015) 128 (6): 1204–1216.
Published: 15 March 2015
...Lénaïg Défachelles; Sarah G. Hainline; Alexandra Menant; Laura A. Lee; Roger E. Karess ABSTRACT Proper kinetochore recruitment and regulation of dynein and the Mad1–Mad2 complex requires the Rod–Zw10–Zwilch (RZZ) complex. Here, we describe rod Z3 , a maternal-effect Drosophila mutation changing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4197–4206.
Published: 15 September 2012
... is a partial loss or gain of checkpoint function, leads to aneuploidy during tumorigenesis. One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Mad1:Mad2 ratio. Changes in Mad1 and Mad2 levels occur in human cancers, where...
Journal Articles
J Cell Sci (2001) 114 (5): 953–963.
Published: 1 March 2001
...Michael S. Campbell; Gordon K. T. Chan; Tim J. Yen ABSTRACT Mad1 was first identified in budding yeast as an essential component of the checkpoint system that monitors spindle assembly in mitosis and prevents premature anaphase onset. Using antibodies to the human homologue of Mad1 (HsMAD1), we...