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Keywords: Macrophages
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Journal Articles
J Cell Sci (2022) 135 (4): jcs259284.
Published: 21 February 2022
...Zachary I. Mendel; Mack B. Reynolds; Basel H. Abuaita; Mary X. O'Riordan; Joel A. Swanson ABSTRACT The internalization of solutes by macropinocytosis provides an essential route for nutrient uptake in many cells. Macrophages increase macropinocytosis in response to growth factors and other stimuli...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs252148.
Published: 8 March 2021
... macrophages as potential antibacterial effectors against intracellular pathogens remains unknown. In this study, we report that normal (wild-type, WT) mouse macrophages increased their expression of cathelin-related antimicrobial peptide (CRAMP, encoded by Camp ) after infection by viable E. coli...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2020) 133 (22): jcs247957.
Published: 27 November 2020
...Jeong-Hun Ko; Antoni Olona; Adonia E. Papathanassiu; Norzawani Buang; Kwon-Sik Park; Ana S. H. Costa; Claudio Mauro; Christian Frezza; Jacques Behmoaras ABSTRACT In response to environmental stimuli, macrophages change their nutrient consumption and undergo an early metabolic adaptation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs249037.
Published: 22 October 2020
...Doris Lou Demy; Mireille Carrère; Ramil Noche; Muriel Tauzin; Marion Le Bris; Chooyoung Baek; Ignaty Leshchiner; Wolfram Goessling; Philippe Herbomel ABSTRACT Most tissues harbor a substantial population of resident macrophages. Here, we elucidate a functional link between the Slc7a7 cationic amino...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs235838.
Published: 12 October 2020
... that topical insulin application could reverse the impaired inflammation reaction in the diabetic wound environment and promote healing of diabetic wounds. Our study revealed that insulin promoted apoptosis of neutrophils and subsequently triggered polarization of macrophages. Both in vivo and in vitro studies...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (12): jcs239384.
Published: 24 June 2020
... accumulation on C3bi-sRBC-containing phagosomes, 2×10 5 RAW 264.7 macrophages stably transfected with LifeAct-RFP were plated in 6-well plates 2 days before the phagocytosis assay. The opsonization protocol for C3bi-sRBCs, as well as the live-cell epifluorescence imaging protocols described earlier, was used...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2020) 133 (5): jcs237560.
Published: 6 March 2020
...Luiz Eduardo Baggio Savio; Paola de Andrade Mello; Stephanie Alexia Cristina Silva Santos; Júlia Costa de Sousa; Suellen D. S. Oliveira; Richard D. Minshall; Eleonora Kurtenbach; Yan Wu; Maria Serena Longhi; Simon C. Robson; Robson Coutinho-Silva; Ana-Maria Lennon-Duménil ABSTRACT Macrophages...
Journal Articles
J Cell Sci (2020) 133 (5): jcs236141.
Published: 28 October 2019
... that aspirin-treated mutant flies experience reduction in metabolic inflammation, mitosis, ectopic immune signaling, and macrophage infiltration. Moreover, these flies synthesize 13-HODE, and aspirin triggers 13-oxoODE (13-EFOX-L 2 ) production. Providing the precursor of 13-HODE, linoleic acid, or performing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs223321.
Published: 11 February 2019
...Samer J. Hanna; Kessler McCoy-Simandle; Edison Leung; Alessandro Genna; John Condeelis; Dianne Cox ABSTRACT The interaction between tumor cells and macrophages is crucial in promoting tumor invasion and metastasis. In this study, we examined a novel mechanism of intercellular communication, namely...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs216267.
Published: 5 June 2018
...Marie Pereira; Enrico Petretto; Siamon Gordon; J. H. Duncan Bassett; Graham R. Williams; Jacques Behmoaras ABSTRACT Macrophage cell fusion and multinucleation are fundamental processes in the formation of multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts...
Journal Articles
J Cell Sci (2017) 130 (24): 4168–4179.
Published: 15 December 2017
...Youhei Egami; Katsuhisa Kawai; Nobukazu Araki ABSTRACT Phagosome formation is a complicated process that requires spatiotemporally regulated actin reorganization. We found that RhoC GTPase is a critical regulator of FcγR-mediated phagocytosis in macrophages. Our live-cell imaging revealed that RhoC...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2530–2540.
Published: 1 August 2017
...), Rac1 activation is required for lamellipodial extension along the surface of IgG-Es. However, the significance of Rac1 deactivation in phagosome formation is poorly understood. Our live-cell imaging and electron microscopy revealed that RAW264 macrophages expressing a constitutively active Rac1 mutant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 344–359.
Published: 15 January 2017
... patches on endosomes and lysosomes, thereby mediating both aforementioned functions. Consistently, loss of WASH function results in cell spreading and cell migration defects of macrophages, and an increased lysosomal acidification that affects efficient phagocytic and autophagic clearance. WASH physically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 298–313.
Published: 15 January 2016
... and additional actin-based regulators of podosomes in primary human macrophages. FHOD1 surrounds the podosome core and is also present at podosome-connecting cables, whereas INF2 localizes at the podosome cap structure. Using a variety of microscopy-based methods; including a semiautomated podosome reformation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 251–265.
Published: 15 January 2015
... License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. WIP WIPF1 Tyrosine phosphorylation Podosome Actin cytoskeleton Macrophages Matrix degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4077–4084.
Published: 15 September 2013
... advantage of the genetic tractability and translucency of zebrafish larvae to first characterise how a null mutant in zfWASp influences the behaviour of neutrophils and macrophages in response to tissue damage and to clearance of infections. We then use this mutant background to study how leukocyte lineage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3043–3054.
Published: 15 July 2013
..., after phagocytic uptake, PLGA NPs remain membrane-bound or whether they escape into the cytoplasm, as has been widely claimed. Second, we sought to make NPs that enclosed sufficient rifampicin to efficiently clear macrophages of infection with Mycobacterium bovis BCG. Using fluorescence microscopy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (21): 3557–3567.
Published: 1 November 2011
... phagocytosis in macrophages. Live-cell image analysis revealed that Rab35 was markedly concentrated at the membrane where IgG-opsonized erythrocytes (IgG-Es) are bound. Rab35 silencing by RNA interference (RNAi) or the expression of GDP- or GTP-locked Rab35 mutant drastically reduced the rate of phagocytosis...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3053–3059.
Published: 15 September 2011
...Emma Colucci-Guyon; Jean-Yves Tinevez; Stephen A. Renshaw; Philippe Herbomel The early control of potentially invading microbes by our immune system primarily depends on its main professional phagocytes – macrophages and neutrophils. Although the different functions of these two cell types have...
Includes: Multimedia, Supplementary data