1-20 of 86
Keywords: Macrophage
Close
Sort by
Journal Articles
J Cell Sci (2023) 136 (14): jcs260809.
Published: 28 July 2023
... facilitate Leishmania entry into macrophages and pathogenesis in murine cutaneous leishmaniasis. Here, we demonstrate that host spleen tyrosine kinase (SYK) is required for efficient uptake of Leishmania promastigotes and amastigotes. A Src-family kinase–Abl-family kinase–SYK signaling cascade induces...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (13): jcs259544.
Published: 8 July 2022
...Kuihao Chen; Qiaoyan Man; Jiaen Miao; Wenjing Xu; Yangchen Zheng; Xiuli Zhou; Zhe Gao ABSTRACT Macrophage polarization plays a key role in the inflammatory response. Various ion channels expressed in macrophages have been documented, but very little is known about their roles in macrophage...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (18): jcs258429.
Published: 15 September 2021
...Marielle Saclier; Sabrina Ben Larbi; Ha My Ly; Eugénie Moulin; Rémi Mounier; Bénédicte Chazaud; Gaëtan Juban ABSTRACT Duchenne muscular dystrophy is a genetic muscle disease characterized by chronic inflammation and fibrosis mediated by a pro-fibrotic macrophage population expressing pro...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (5): jcs252320.
Published: 11 February 2021
... of borreliae by immune cells, like macrophages, is decisive for the outcome of a respective infection. Here, we use, for the first time, focused ion beam scanning electron microscopy tomography (FIB-SEM tomography) to visualize the interaction of borreliae with primary human macrophages with high resolution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs248864.
Published: 23 December 2020
... RAW264.7 macrophages and primary murine macrophages undergoing interleukin (IL-4)-induced MGC formation. CD301 + MGCs were identified in biopsy specimens of human inflammatory lesions. Function-inhibiting CD301 antibodies or CRISPR/Cas9 deletion of the two mouse CD301 genes (Mgl1 and Mgl2) inhibited IL-4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248344.
Published: 3 December 2020
... kinase BTK Macrophage Receptor signaling Else-Kröner-Fresenius Stiftung 2013_A210 Deutsche Forschungsgemeinschaft 10.13039/501100001659 CRC TR156 We-4195/15-1 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg 10.13039/501100003542 33-7533-7...
Journal Articles
Journal Articles
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2020) 133 (13): jcs239871.
Published: 8 July 2020
... responses in the non-ciliated macrophage. We propose that ciliary proteins, including IFT88, KIF3A, TTBK2 and NPHP4, act outside of the ciliary axoneme to tune cytoplasmic NFκB signalling and specify the downstream cell response. This is thus a non-canonical function for ciliary proteins in shaping cellular...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (7): jcs239939.
Published: 8 April 2020
...:   Leishmania effluxes host ATP generated from increased glycolysis, which is converted into extracellular adenosine to create an anti-inflammatory milieu within infected cells via receptor-mediated signalling. ATP Ectonucleotidase Adenosine receptor Leishmania donovani Macrophage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs237883.
Published: 5 March 2020
... of phagocytosis, and changes in macrophage morphology during phagocytosis related to both engulfment and target degradation. Our results provide a high-resolution method for quantifying phagocytosis that provides opportunities to better understand the cellular and molecular regulation of this fundamental...
Journal Articles
J Cell Sci (2019) 132 (23): jcs237271.
Published: 2 December 2019
...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs224618.
Published: 18 February 2019
... rearrangements drive macrophage recruitment to wounds in Drosophila . We find that the actin-regulatory protein Ena is a master regulator of lamellipodial dynamics in migrating macrophages, where it remodels the cytoskeleton to form linear filaments that can then be bundled together by the cross-linker Fascin...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (5): jcs213272.
Published: 6 March 2018
... to form PtdIns(5)P in vitro . However, the in vivo conversion of the polyphosphoinositide into PtdIns(5)P by the phosphatase has not yet been demonstrated, and the role of TMEM55a remains poorly understood. Here, we found that mouse macrophages (Raw264.7) deficient in TMEM55a showed an increased...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (22): 3801–3808.
Published: 15 November 2017
...Francisco Barros-Becker; Pui-Ying Lam; Robert Fisher; Anna Huttenlocher ABSTRACT Cell motility is required for diverse processes during immunity and inflammation. Classically, leukocyte motility is defined as an amoeboid type of migration, however some leukocytes, like macrophages, also employ...
Includes: Supplementary data