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Keywords: MMP9
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Journal Articles
J Cell Sci (2017) 130 (19): 3374–3387.
Published: 1 October 2017
...-1/ Summary: The armadillo protein p0071 controls directional vesicular transport mediated by the KIF3 (kinesin-2) complex, and secretion of respective cancer-relevant cargos from neuroendocrine and pancreatic tumor cells. p0071 Chromogranin MMP9 Kinesin-2 KIF3 Protein transport...
Includes: Supplementary data
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J Cell Sci (2016) 129 (23): 4341–4353.
Published: 1 December 2016
... in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3478–3488.
Published: 15 September 2015
... as PLAT) or MMP9-PEX into crush-injured sciatic nerves activated ERK1/2 in Schwann cells in vivo , and the response was blocked by systemic treatment with the NMDA-R inhibitor MK801. tPA was unique among the LRP1 ligands examined because tPA activated cell signaling and promoted Schwann cell migration...
Journal Articles
J Cell Sci (2013) 126 (20): 4647–4658.
Published: 15 October 2013
... by targeted secretion of various matrix metalloproteinases (MMPs). Specifically, MMP2 and MMP9 (MMP2/9) possess the ability to hydrolyze components of the basement membrane and regulate various aspects of tumor growth and metastasis. However, the membrane transport machinery that mediates targeting of MMP2/9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 47–56.
Published: 1 January 2011
... regulator of cell behaviour during limb regeneration, but it is unclear how it signals to the interior of the cell. Prod1 was expressed by transfection in cultured newt limb cells and activated transcription and expression of matrix metalloproteinase 9 (MMP9) by a pathway involving ligand-independent...
Includes: Supplementary data