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Keywords: MMP2
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Journal Articles
J Cell Sci (2019) 132 (16): jcs231399.
Published: 22 August 2019
..., our study indicated that MKL1 promoted the migration and invasion of PTC cells. MKL1 interacted with and recruited Smad3 to the promoter of MMP2 to activate MMP2 transcription upon treatment with TGF-β. Moreover, there was significant correlation between expression of TGF-β, MKL1 and MMP2 in our...
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J Cell Sci (2016) 129 (23): 4341–4353.
Published: 1 December 2016
... in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4647–4658.
Published: 15 October 2013
... by targeted secretion of various matrix metalloproteinases (MMPs). Specifically, MMP2 and MMP9 (MMP2/9) possess the ability to hydrolyze components of the basement membrane and regulate various aspects of tumor growth and metastasis. However, the membrane transport machinery that mediates targeting of MMP2/9...
Includes: Supplementary data