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Keywords: MMP14
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Journal Articles
J Cell Sci (2019) 132 (11): jcs223172.
Published: 5 June 2019
... in MDA-MB-231 breast cancer cells in which early endosomes demonstrated aberrantly enriched F-actin and accumulated the metalloproteinase MT1-MMP (also known as MMP14) upon DLC3 knockdown. Remarkably, Rab4 (herein referring to Rab4A) downregulation fully rescued the enhanced matrix degradation of TGF-β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 2983–2988.
Published: 15 August 2015
.... Antibody-mediated blocking of FGFR1 during basal-cell–endothelial-cell co-culture significantly reduced the endothelial-cell-dependent basal cell growth. Stimulation of endothelial cells with basal-cell-derived growth factors induced endothelial cell expression of matrix metallopeptidase 14 (MMP14...
Journal Articles
J Cell Sci (2014) 127 (18): 3893–3901.
Published: 15 September 2014
... matrix metalloproteinase MT1-MMP (also known as MMP14). In MDA-MB-231 cells, MT1-MMP and CLIC3 are localized primarily to late endosomal/lysosomal compartments located above the plane of adhesion and near the nucleus. MT1-MMP is transferred from these late endosomes to sites of cell–matrix adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4039–4050.
Published: 1 December 2011
... by β1 integrins, including α5β1 integrin. We have examined the role of extracellular proteases in regulating ECM fibronectin turnover. Our data show that membrane type matrix metalloproteinase 1 (MT1-MMP; also known as MMP14) is a crucial regulator of fibronectin turnover. Cells lacking MT1-MMP show...
Includes: Supplementary data