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1-9 of 9
Keywords: MMP-9
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (23): 4366–4379.
Published: 1 December 2015
... and epithelial–mesenchymal transition (EMT) in epithelial cysts. MMP-9 secreted by carcinoma cells cleaves cellular E-cadherin (encoded by CDH1 ) from epithelial cells to generate soluble E-cadherin (sE-cad), a pro-oncogenic protein. We show that sE-cad induces EGFR activation, resulting in lumen filling in MDCK...
Includes: Supplementary data
Journal Articles
Piotr Michaluk, Marcin Wawrzyniak, Przemyslaw Alot, Marcin Szczot, Paulina Wyrembek, Katarzyna Mercik, Nikolay Medvedev, Ewa Wilczek, Mathias De Roo, Werner Zuschratter, Dominique Muller, Grzegorz M. Wilczynski, Jerzy W. Mozrzymas, Michael G. Stewart, Leszek Kaczmarek, Jakub Wlodarczyk
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (19): 3369–3380.
Published: 1 October 2011
... An increasing body of data has shown that matrix metalloproteinase-9 (MMP-9), an extracellularly acting, Zn 2+ -dependent endopeptidase, is important not only for pathologies of the central nervous system but also for neuronal plasticity. Here, we use three independent experimental models to show that enzymatic...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (13): 2220–2230.
Published: 1 July 2011
... metalloproteinase-9 (MMP-9) in vitro and in vivo, and thus enhances invasion and migration. We also show that fos plays a crucial role in the transcriptional activation of MMP-9 by S1P. In addition, activation of extracellular-signal-regulated kinases 1 and 2 (ERK1/2), p38 and alpha serine/threonine-protein kinase...
Journal Articles
Mireia Jordà, David Olmeda, Antònia Vinyals, Eva Valero, Eva Cubillo, Ana Llorens, Amparo Cano, Àngels Fabra
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (15): 3371–3385.
Published: 1 August 2005
... that the expression of Snail is associated with an increase in the promoter activity and expression of the matrix metalloproteinase MMP-9. The effect of Snail silencing on MMP-9 expression corroborates this finding. Induced transcription of MMP-9 by Snail is driven by a mechanism dependent on the MAPK...
Journal Articles
Christina H. Stuelten, Stacey DaCosta Byfield, Praveen R. Arany, Tatiana S. Karpova, William G. Stetler-Stevenson, Anita B. Roberts
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (10): 2143–2153.
Published: 15 May 2005
... to investigate tumor-stroma interactions in breast cancer and to identify possible signaling pathways involved. Tumor cells induced expression of matrix-metalloproteinase 9 (MMP-9) in fibroblasts in a pattern dependent on the degree of their malignancy. In-situ zymography localized the main gelatinolytic...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (6): 1185–1195.
Published: 15 March 2005
... keratinocytes during cutaneous wound healing. We showed previously that α3β1 is required for MMP-9/gelatinase B secretion in immortalized mouse keratinocytes (MK cells) and that this regulation was acquired as part of the immortalized phenotype, suggesting a possible role for α3β1 during malignant conversion...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (21): 3813–3822.
Published: 1 November 2001
... in the presence of monocytes. In culture medium from cocultures we detected active forms of the matrix metalloproteinases MMP-1, MMP-3 and MMP-9 accompanied by induction of gene expression of MMP-1, membrane type 1 MMP (MT1-MMP) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in chondrocytes. No gene...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (12): 3649–3659.
Published: 1 December 1995
... hybridizations reveal the expression of 2 MMPs, gelatinase B (MMP-9 or 92 kDa type IV collagenase) in (pre)osteoclasts, and interstitial collagenase (MMP-13) in hypertrophic chondrocytes. It is concluded that only MMPs appear obligatory for the migration of (pre)osteoclasts, and that this role is distinct from...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (2): 477–486.
Published: 1 February 1994
... © 1994 by Company of Biologists 1994 MMP-9 92 kDa type IV collagenase/gelatinase fibroblast metastasis Degradation of the extracellular matrix and basement membrane is an essential component of several steps in tumor invasion, angiogenesis and metastasis (Liotta...