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Keywords: MDM2
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Journal Articles
J Cell Sci (2018) 131 (9): jcs210724.
Published: 8 May 2018
... of the increased expression of dehydrogenase/reductase 2 (DHRS2), a putative MDM2 inhibitor. We observed that HDIS occurred without decreased levels of major HSPs or increased proteotoxic stress in HDFs. Additionally, VER155008, an inhibitor of HSP70 family proteins, increased proteotoxicity and suppressed cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2436–2445.
Published: 1 June 2013
... with p53 and MDM2, and strongly enhances MDM2-dependent p53 ubiquitylation and degradation. We also found that RBEL1A modulation of p53 ubiquitylation by MDM2 does not depend on its GTPase activity. We have also defined the p53 oligomeric domain and RBEL1A GTPase domain to be the crucial regions for p53...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1067–1076.
Published: 1 April 2011
... of an antagonistic relationship between Notch 4 and Trp53, which is controlled by the Mdm2-dependent ubiquitylation and degradation of the Notch receptor. We show that this signal-controlling mechanism is mediated by physical interactions between Mdm2 and Notch 4 and suggest the existence of a trimeric complex...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (24): 4037–4046.
Published: 15 December 2008
...Lingjun Meng; Tao Lin; Robert Y. L. Tsai Nucleolar disassembly occurs during mitosis and nucleolar stress, releasing several MDM2-interactive proteins residing in the nucleolus that share the common activity of p53 stabilization. Here, we demonstrate that mobilization of nucleostemin, a nucleolar...
Includes: Supplementary data
Journal Articles
Journal Articles