... and Blow, 2000), but has the final control in determining when Mcm2 can be phosphorylated during S phase. We believe that this phosphorylation sets off a chain reaction that results in a conformational change in the MCM complex allowing the recruitment of Cdc45, which both disengages the MCM helicase from...

... for the recruitment of Cdc45 and other downstream components of the elongation machinery. DNA replication MCM helicase Mcm10 Cdt1/DUP CDK Cdc7-Dbf4 The eukaryote genome is organized into multiple chromosomes, whose replication must be coordinated so that one genome equivalent of DNA is precisely...