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Keywords: MAPK
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Journal Articles
J Cell Sci (2022) 135 (16): jcs260148.
Published: 19 August 2022
...Jeffrey A. Hadwiger; Huaqing Cai; Ramee G. Aranda; Saher Fatima ABSTRACT The Dictyostelium atypical mitogen-activated protein kinase (MAPK) Erk2 is required for chemotactic responses to cAMP as amoeba undergo multicellular development. In this study, Erk2 was found to be essential for the cAMP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 3 September 2021
...Neal R. Rasmussen; David J. Reiner ABSTRACT The extracellular signal-regulated kinases (ERKs) are mitogen-activated protein kinases (MAPKs) that are utilized downstream of Ras to Raf to MEK signaling to control activation of a wide array of targets. Activation of ERKs is elevated in Ras-driven...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs258341.
Published: 4 August 2021
...Aditi Prabhakar; Beatriz González; Heather Dionne; Sukanya Basu; Paul J. Cullen ABSTRACT Mitogen-activated protein kinase (MAPK) pathways control cell differentiation and the response to stress. In Saccharomyces cerevisiae , the MAPK pathway that controls filamentous growth (fMAPK) shares...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs241513.
Published: 14 April 2020
...@buffalo.edu ) Competing interests The authors declare no competing or financial interests. 7 11 2019 12 2 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: A differentiation-type MAPK pathway in yeast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs230706.
Published: 31 May 2019
... on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...
Journal Articles
J Cell Sci (2019) 132 (11): jcs224071.
Published: 31 May 2019
... anisotropy, focal adhesion density and cell stiffness were characteristics associated with efficient passage through constraints. By comparing transcriptomic profiles between the parental and selected populations, increased Ras/MAPK signalling was linked with cytoskeleton rearrangements and cell softening...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (9): jcs213462.
Published: 4 May 2018
...Antonio Serrano; Julia Illgen; Ulrike Brandt; Nils Thieme; Anja Letz; Alexander Lichius; Nick D. Read; André Fleißner ABSTRACT Mitogen-activated protein kinases (MAPKs) are conserved regulators of proliferation, differentiation and adaptation in eukaryotic cells. Their activity often involves...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs204644.
Published: 1 February 2018
... relocalized in the cytosol, Net1A stimulates cell motility and extracellular matrix invasion. In the present work, we investigated mechanisms responsible for the cytosolic relocalization of Net1A. We demonstrate that inhibition of MAPK pathways blocks Net1A relocalization, with cells being most sensitive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4499–4511.
Published: 15 December 2015
...Eric T. Hall; Esther M. Verheyen ABSTRACT Wnt/Wingless (Wg) and Ras–MAPK signaling both play fundamental roles in growth and cell fate determination, and when dysregulated, can lead to tumorigenesis. Several conflicting modes of interaction between Ras–MAPK and Wnt signaling have been identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2749–2760.
Published: 15 June 2014
... in mitogen-activated protein kinase (MAPK) activity is essential for pronuclear formation, but the precise timing and mechanism of decline are unknown. Here, we have measured the dynamics of MAPK pathway inactivation during fertilization of mouse eggs using novel chemiluminescent MAPK activity reporters...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 845–857.
Published: 15 February 2014
... mitogen activated protein kinases (MAPK3 and MAPK1), but also suppressed TGFβ-induced activation of Smad2 by modulating Smad2 phosphorylation by MAPKs. These results suggest that FGF2 regulates LEC-specific gene expression and suppresses TGFβ signalling in LECs through Smad2 in a Ras–MAPK-dependent manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3324–3332.
Published: 1 August 2013
...Katarzyna M. Kowalczyk; Sonya Hartmuth; David Perera; Peter Stansfield; Janni Petersen Summary In all eukaryotes tight control of mitogen-activated protein kinase (MAPK) activity plays an important role in modulating intracellular signalling in response to changing environments. The fission yeast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4264–4277.
Published: 15 September 2012
... ) 29 5 2012 © 2012. Published by The Company of Biologists Ltd 2012 Purinergic receptor Hemidesmosome β4 Integrin p90RSK Gαq MAPK ERK1/2 Migration Keratinocyte Hemidesmosomes (HD) are multiprotein complexes that promote stable adhesion of basal epithelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2698–2708.
Published: 1 June 2012
... © 2012. 2012 LAMTOR2 Macrophage MAPK Phagosome Salmonella Recently, a novel primary immunodeficiency syndrome was identified and traced back to a homozygous single point mutation in the human LAMTOR2 (p14) gene, causing reduced p14 protein expression and subsequently severe...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (6): 1383–1391.
Published: 15 March 2012
... have uncovered a new mechanism of specificity that is based on competition between CIC and other MAPK substrates, such as BCD ( Kim et al., 2010 ; Kim et al., 2011a ). Specifically, the presence of BCD in anterior regions of the embryo counteracts the activity of MAPK towards CIC, thereby potentiating...
Journal Articles
J Cell Sci (2011) 124 (7): 1032–1042.
Published: 1 April 2011
...-interacting protein-1 (JIP1) and kinase-D-interacting substrate of 220 kDa (Kidins220). KLC1ser460 is a predicted mitogen-activated protein kinase (MAPK) target site, and we show that extracellular-signal-regulated kinase (ERK) phosphorylates this residue in vitro. We also demonstrate that inhibition of ERK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4310–4320.
Published: 15 December 2010
...@bristol.ac.uk ) 3 9 2010 © 2010. 2010 ERK MAPK Protein kinase C Epidermal growth factor Docking domain Nuclear localization High-content analysis A wide variety of extracellular signals activate the Raf–MEK–ERK pathway. In this cascade, Raf isoforms are recruited to the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1060–1072.
Published: 1 April 2010
... evidence for the existence of ER microdomains that are involved in the regulation of BIT1 structure and trafficking, and identifies BIT1 as a negative regulator of the ERK-MAPK signaling pathway in the Golgi. BIT1 MAPK Secretory pathway Stress Data were analyzed for homologies using BLAST...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1737–1746.
Published: 1 June 2009
... protein kinase (MAPK) Sty1 (also known as Spc1). Here we show that `nutrient starvation' (complete withdrawal of nitrogen or leucine) blocks mitotic commitment by altering Sty1 signalling and that different degrees of Sty1 activation determine these differences in mitotic commitment decisions. Mammals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (6): 1093–1103.
Published: 15 March 2007
... the inhibitors U0126 for mitogen-activated protein kinase (MAPK), and ZM447439 for Aurora kinase A and Aurora kinase B, we found that MAPK is required for phosphorylation of CPEB, whereas Aurora kinases are not. Furthermore, we do not detect active Aurora kinase A in early meiosis. By contrast, we observe...