... regulation. MAP kinase Chemotaxis Signal transduction Dictyostelium Transcription factor Cancer National Institutes of Health R15 GM131269-02 Mitogen-activated protein kinases (MAPKs) are a large family of protein kinases that serve important roles in eukaryotic signal...

... (CIP) and its core component, the MAP kinase Pmk1 (also known as Spm1), in response to environmental stimuli. We show that in vivo phosphorylation of Pck2 at the conserved T842 activation loop during growth and in response to different stresses is mediated by the phosphoinositide-dependent kinase (PDK...

... regulating RAS-mediated RAF activation.   Oncogene   26 , 3143 – 3158 . 10.1038/sj.onc.1210408 Cobb   M. H. , Goldsmith   E. J. ( 2000 ). Dimerization in MAP-kinase signaling.   Trends Biochem. Sci.   25 , 7 – 9 . 10.1016/S0968-0004(99)01508-X De Celis   J. F. ( 2003 ). Pattern...

... © The Company of Biologists Limited 2009 2009 Integrin Epithelial morphogenesis Adhesion GATA4 MAP kinase Integrins are extracellular matrix (ECM) receptors composed of two noncovalently linked subunits, α and β. They have been implicated in the regulation of many cellular...

... of the pre-TNFα–TACE complex. * Authors for correspondence (e-mails: [email protected] ; [email protected] ) 19 10 2007 © The Company of Biologists Limited 2008 2008 COT TNF MAP kinase TACE TLR Tumour necrosis factor α (TNFα) is a key player in inflammatory...

... and chemotactic migration. However, the lack of direct visualisation of cell migration in WAVE2 mutants or knockdowns has made defining the mechanisms of WAVE2 regulation during cell migration difficult. We have characterised three MAP kinase phosphorylation sites within WAVE2 and analysed fibroblast behaviour...

... import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 18 , 5347 -5358. Adachi, M., Fukuda, M. and Nishida, E. ( 2000 ). Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J. Cell Biol. 148 , 849...

...Wen Ling Zhang; Philippe Huitorel; Anne-Marie Geneviere; Sandrine Chiri; Brigitte Ciapa Unfertilized sea urchin eggs that are arrested at G1 phase after completion of meiosis contain a highly phosphorylated mitogen-activated protein (MAP) kinase (MAPK), the ERK-like protein (ERK-LP). Several data...

...-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes. J. Cell Sci. 114 , 257 -267. Armstrong, R. N. ( 1997 ). Structure, catalytic mechanism and evolution of the glutathione transferases. Chem. Res. Toxicol. 10 , 2 -8. Canagarajah, B., Khokhlatchev, A. V., Cobb, M. H...

... and constitutively active form of the ALK protein tyrosine kinase (PTK) domain induced the neuron-like differentiation of PC12 cells through specific activation of the mitogen-activated protein kinase (MAP kinase) pathway. Its PTK domain had been originally identified in a nucleo-cytosolic and constitutively active...

...Miki Ebisuya; Kunio Kondoh; Eisuke Nishida ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell proliferation, differentiation, migration and survival. One of the central questions concerning this signaling is how activation of the same protein kinase, ERK...

... observations that phosphorylation of TACE at Thr735 highlights a key step in inducible TACE protein trafficking and maturation. * Author for correspondence (e-mail: [email protected] ) 2 3 2005 © The Company of Biologists Limited 2005 2005 ERK MAP kinase TACE phosphorylation TACE...

.... C. and Kraft, A. S. ( 1992 ). Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. Proc. Natl. Acad. Sci. USA 89 , 5341 -5345. Alepuz, P. M., Jovanovic, A., Reiser, V. and Ammerer, G. ( 2001 ). Stress-induced map kinase Hog1...

... 2004 2004 Telomere Centromere Sister chromatid Meiosis MAP kinase Meiosis, a process of general importance for sexually reproducing eukaryotic organisms, generates inheritable haploid gametes from a diploid cell. This process of halving the chromosome number is achieved by two...

... by MEK inhibitor PD98059 but not by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin, indicating an essential role of the mitogen-activated protein kinase (MAP kinase) signaling cascade in ALK-mediated growth and differentiation of neurons. Hybridoma clone 16-39 was cultured...

...Rene E. Harrison; Barbara A. Sikorski; Jan Jongstra The identification and characterization of scaffold and targeting proteins of the ERK/MAP kinase pathway is important to understand the function and intracellular organization of this pathway. The F-actin binding protein leukocyte-specific protein...

... in resting cells, indicating that each MAPK cascade uses distinct mechanisms to transmit extracellular signals to their nuclear targets. * Author for correspondence (e-mail: [email protected] ) 4 12 2003 © The Company of Biologists Limited 2004 2004 MAP Kinase ERK5 MEK5...

... with CEP-11004 was specific for MLK, because neither the MLK-related DLK nor activation of ERK was affected ( Fig. 2B,C ). * Author for correspondence (e-mail: [email protected] ) 19 9 2003 © The Company of Biologists Limited 2004 2004 MAP kinase Phosphorylation...

... 2003 © The Company of Biologists Limited 2003 2003 IGF-1 EGF Cell shape Wound epithelialization MAP kinase PI-3 kinase The outer covering of the skin, the epidermis, is exposed to the environment and is therefore particularly prone to injury. As a response to damage...

...Graeme R. Guy; Esther S. M. Wong; Permeen Yusoff; Sumana Chandramouli; Ting Ling Lo; Jormay Lim; Chee Wai Fong Since the discovery of the prototypical Sprouty (Spry) protein in Drosophila , there has been an effort to determine how these novel modulators of the Ras/MAP-kinase pathway function...