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1-8 of 8
Keywords: MAD2
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (5): 1207–1217.
Published: 1 March 2013
... of the spindle assembly checkpoint protein Mad2. This results in a strengthening of the spindle assembly checkpoint and renders cells more sensitive to the spindle poison paclitaxel. Constitutive Rb phosphorylation also causes a weakening of the p53-dependent tetraploidy checkpoint. Cells with overactive Cdk2...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (18): 4197–4206.
Published: 15 September 2012
... is a partial loss or gain of checkpoint function, leads to aneuploidy during tumorigenesis. One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Mad1:Mad2 ratio. Changes in Mad1 and Mad2 levels occur in human cancers, where...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (24): 4332–4345.
Published: 15 December 2011
... composed of three SAC components, namely BubR1, Bub3 and Mad2, and the APC/C co-activator Cdc20. The molecular mechanisms underlying exactly how unattached kinetochores catalyse MCC formation and how the MCC then inhibits the APC/C remain obscure. Here, using RNAi complementation and in vitro...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (10): 1664–1671.
Published: 15 May 2011
... is the receptor for Mad2 at kinetochores, where it catalyzes the formation of Mad2–Cdc20 complexes, an essential part of the anaphase inhibitor, but whether it has any other mitotic function is unknown. We have generated a mad1 -null mutation in Drosophila . This mutant is SAC defective and Mad2 is no longer...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (19): 3787–3795.
Published: 1 October 2002
...Julie C. Canman; Nitin Sharma; Aaron Straight; Katie B. Shannon; Guowei Fang; E. D. Salmon Spindle checkpoint proteins, such as Mad2 and BubR1, and the motors dynein/dynactin and CENP-E usually leave kinetochores prior to anaphase onset by microtubule-dependent mechanisms. Likewise, `chromosome...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (8): 1603–1610.
Published: 15 April 2002
...Amy E. Ikui; Kanji Furuya; Mitsuhiro Yanagida; Tomohiro Matsumoto To ensure accurate chromosome segregation, the spindle checkpoint delays the onset of sister chromatid separation when the spindle is not attached to a kinetochore. Mad2, a component of the checkpoint, targets fission yeast Slp1...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (23): 4173–4183.
Published: 1 December 2001
...R. Bruce Nicklas; Jennifer C. Waters; E. D. Salmon; Suzanne C. Ward The spindle checkpoint detects errors in kinetochore attachment to microtubules and delays anaphase if attachment is improper. The checkpoint is activated by attachment-sensitive components including Mad2 and certain phosphorylated...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (5): 953–963.
Published: 1 March 2001
... 2001 by Company of Biologists 2001 Nuclear pore complex MAD1 MAD2 Kinetochore Checkpoint The mitotic checkpoint is a regulatory mechanism that prevents aneuploidy by delaying sister chromatid separation before all chromosomes have aligned at the metaphase plate. Following nuclear...