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Keywords: Lysosomes
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Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (5): jcs255026.
Published: 20 April 2021
...Yuan Gao; Juan Xiong; Qing-Zhu Chu; Wei-Ke Ji ABSTRACT Membrane contact sites (MCSs) between the endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (6): jcs256578.
Published: 11 March 2021
...Yu Yuan; Bethan S. Kilpatrick; Susanne Gerndt; Franz Bracher; Christian Grimm; Anthony H. Schapira; Sandip Patel ABSTRACT Lysosomes are acidic Ca 2+ stores often mobilised in conjunction with endoplasmic reticulum (ER) Ca 2+ stores. Glycyl-L-phenylalanine 2-naphthylamide (GPN) is a widely used...
Journal Articles
J Cell Sci (2019) 132 (24): jcs235390.
Published: 13 December 2019
.... lysosomes, mitochondria and peroxisomes) by taking advantage of the extraordinarily high affinity between the twin strep tag and streptavidin variants. With this method, we can isolate desired organelles with high purity and yield in 3 min from the post-nuclear supernatant of mammalian cells or less than 8...
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (23): jcs226241.
Published: 30 November 2018
... extensively studied the dynamics of this response using both live-cell imaging and correlative light-electron microscopy (CLEM), and found that it correlates with lysosomal damage and is characterised by the recruitment of the selective autophagy-associated proteins TANK-binding kinase 1 (TBK1) and optineurin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs213587.
Published: 21 May 2018
...Christopher H. Choy; Golam Saffi; Matthew A. Gray; Callen Wallace; Roya M. Dayam; Zhen-Yi A. Ou; Guy Lenk; Rosa Puertollano; Simon C. Watkins; Roberto J. Botelho ABSTRACT Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3859–3867.
Published: 15 October 2016
...Bethan S. Kilpatrick; Elizabeth Yates; Christian Grimm; Anthony H. Schapira; Sandip Patel ABSTRACT Transient receptor potential (TRP) mucolipins (TRPMLs), encoded by the MCOLN genes, are patho-physiologically relevant endo-lysosomal ion channels crucial for membrane trafficking. Several lines of...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2016) 129 (13): 2475–2481.
Published: 01 July 2016
...Gennaro Napolitano; Andrea Ballabio ABSTRACT The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3744–3756.
Published: 15 October 2015
... function in these cells remains unknown. Here, we show that rapsyn plays an AChR-independent role in organizing the distribution and mobility of lysosomes. In cells devoid of AChRs, rapsyn selectively induces the clustering of lysosomes at high density in the juxtanuclear region without affecting the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 232–238.
Published: 15 January 2015
... organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients with the common G2019S mutation in LRRK2. Defects were corrected by molecular silencing of TPC2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2934–2943.
Published: 01 July 2014
...Christopher J. Penny; Bethan S. Kilpatrick; Jung Min Han; James Sneyd; Sandip Patel ABSTRACT Acidic organelles form an important intracellular Ca 2+ pool that can drive global Ca 2+ signals through coupling with endoplasmic reticulum (ER) Ca 2+ stores. Recently identified lysosome–ER membrane...
Journal Articles
J Cell Sci (2013) 126 (22): 5143–5152.
Published: 15 November 2013
...Thomas Burgoyne; Rushee Jolly; Belen Martin-Martin; Miguel C. Seabra; Rosanna Piccirillo; Maria Vittoria Schiaffino; Clare E. Futter Summary Multivesicular endosomes/bodies (MVBs) deliver proteins, such as activated EGF receptor (EGFR), to the lysosome for degradation, and, in pigmented cells, MVBs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3552–3562.
Published: 15 August 2013
...: some is recycled to the plasma membrane via Rab11-labelled recycling endosomes; the remaining PrP Sc is subject to retromer-mediated retrograde transport to the Golgi. This pathway leads to lysosomal degradation, and we show that this is the dominant PrP Sc degradative mechanism in the early stages of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3575–3584.
Published: 15 August 2013
...Taeko Soma-Nagae; Shigeyuki Nada; Mari Kitagawa; Yusuke Takahashi; Shunsuke Mori; Chitose Oneyama; Masato Okada Summary The lysosomal adaptor protein p18 is an essential anchor of a scaffolding complex for the mTORC1 and MAPK pathways, which play crucial roles in controlling cell growth and energy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 60–66.
Published: 01 January 2013
... remains unclear. Here we show that rapid osmotic permeabilisation of lysosomes evokes prolonged, spatiotemporally complex Ca 2+ signals in primary cultured human fibroblasts. These Ca 2+ signals comprised an initial response that correlated with lysosomal disruption and secondary long-lasting spatially...
Journal Articles
J Cell Sci (2011) 124 (3): 459–468.
Published: 01 February 2011
...Silvia Vergarajauregui; Jose A. Martina; Rosa Puertollano Loss-of-function mutations in mucolipin 1 (MCOLN1) result in mucolipidosis type IV (MLIV), a lysosomal storage disorder characterized by severe mental and psychomotor retardation. MCOLN1 is a lysosomal ion channel that belongs to the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (9): 1480–1491.
Published: 01 May 2010
...Cinzia Progida; Laura Cogli; Francesco Piro; Azzurra De Luca; Oddmund Bakke; Cecilia Bucci Rab7b is a recently identified member of the Rab GTPase protein family and has high similarity to Rab7. It has been reported that Rab7b is lysosome associated, that it is involved in monocytic differentiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 782–791.
Published: 01 March 2007
...Roberta Kiffin; Susmita Kaushik; Mei Zeng; Urmi Bandyopadhyay; Cong Zhang; Ashish C. Massey; Marta Martinez-Vicente; Ana Maria Cuervo Rates of autophagy, the mechanism responsible for lysosomal clearance of cellular components, decrease with age. We have previously described an age-related decline...
Journal Articles
J Cell Sci (2005) 118 (22): 5243–5255.
Published: 15 November 2005
...Juan M. Falcón-Pérez; Ramin Nazarian; Chiara Sabatti; Esteban C. Dell'Angelica Late endosomes and lysosomes of mammalian cells in interphase tend to concentrate in the perinuclear region that harbors the microtubule-organizing center. We have previously reported abnormal distribution of these...
Journal Articles
J Cell Sci (2005) 118 (15): 3387–3395.
Published: 01 August 2005
... membrane, which result in sustained growth stimulation. * Author for correspondence (e-mail: thomas.reinheckel@uniklinik-freiburg.de ) 5 5 2005 © The Company of Biologists Limited 2005 2005 Cathepsins Epidermis Hair follicle Lysosomes Mice Knockout The molecular...
Journal Articles
J Cell Sci (2005) 118 (14): 3091–3102.
Published: 15 July 2005
... inactivation of LAMP2 by RNA interference or by homologous recombination leads to autophagic vacuolization in nutrient-depleted cells. Cells that lack LAMP2 expression showed an enhanced accumulation of vacuoles carrying the marker LC3, yet a decreased colocalization of LC3 and lysosomes, suggesting that the...