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Keywords: Lysosome
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Journal Articles
J Cell Sci jcs.255463.
Published: 28 April 2021
...Luther J. Davis; Nicholas A. Bright; James R. Edgar; Michael D.J. Parkinson; Lena Wartosch; Judith Mantell; Andrew A. Peden; J. Paul Luzio To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing increased...
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
... Lysosome Nuclear calcium Ca 2+ ions influence numerous signaling pathways within the vast majority of cells and thus impact nearly every aspect of life ( Berridge et al., 2000 ). In order to adapt to changing intra- and extra-cellular conditions, cells must induce specific signaling cascades to...
Journal Articles
J Cell Sci (2021) 134 (4): jcs256255.
Published: 22 February 2021
...: Live imaging of mitophagy reporter zebrafish shows mitophagy occurs via a piece-by-piece mechanism in vivo . Hypoxia induces mitophagy in muscle in a bnip3 -dependent but pink1 -independent manner. Autophagy Hypoxia Fasting Mitochondria Lysosome Mitophagy is the removal of damaged...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs248658.
Published: 27 January 2021
...Anthony J. Morgan; Antony Galione ABSTRACT Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca 2+ entry (SOCE) by these agents...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs247080.
Published: 09 July 2020
... endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment of Rab7 to endosomes requires the Mon1–Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1–Ccz1 complex requires a third...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs236661.
Published: 11 June 2020
..., disruption of several Rab proteins can manifest in metabolic diseases or cancer. Rab32 is expressed in many secretory epithelial cells but its role in cellular metabolism is virtually unknown. In this study, we find that Rab32 associates with lysosomes and regulates proliferation and cell size of Hep3B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs228114.
Published: 22 May 2020
...Åsa B. Birgisdottir; Terje Johansen ABSTRACT Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded. In...
Journal Articles
J Cell Sci (2019) 132 (21): jcs222570.
Published: 13 November 2019
... into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis. * Author for correspondence ( sabatini@wi.mit.edu ) Competing interests The authors declare no competing or financial interests. © 2019...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs231753.
Published: 09 October 2019
... yet been defined. In this study, experiments using quantitative colocalization analysis reveal that COMMD1 modulates copper-responsive ATP7B trafficking through recruitment to PtdIns(4,5)P 2 . Decreased COMMD1 abundance results in loss of ATP7B from lysosomes and the trans -Golgi network (TGN) in high...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2019) 132 (19): jcs234195.
Published: 01 October 2019
... independent of the complex's activity as a RAB-3 GAP and a RAB-18 GEF. Loss of rbg-1 activity promotes lysosomal biogenesis and function, and also suppresses the accumulation of non-functional autolysosomes in epg-5 mutants. The mobility of late endosome- and lysosome-associated RAB-7 is reduced in epg-5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs189134.
Published: 15 May 2019
...Jan van der Beek; Caspar Jonker; Reini van der Welle; Nalan Liv; Judith Klumperman ABSTRACT Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of the endo-lysosomal system. They...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs226183.
Published: 25 March 2019
... fibroblasts independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca 2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair. This article has...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs229500.
Published: 28 February 2019
... early endosomes in melanocytes, called stage I melanosomes. PIKfyve activity controls the membrane remodeling of stage I melanosomes, which regulates PMEL abundance, sorting and processing. PIKfyve activity also affects stage I melanosome kiss-and-run interactions with lysosomes, which are required for...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs223883.
Published: 01 February 2019
...Peace Atakpa; Laura M. van Marrewijk; Michael Apta-Smith; Sumita Chakraborty; Colin W. Taylor ABSTRACT The dipeptide glycyl- l -phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (19): jcs214304.
Published: 04 October 2018
.../s41467-017-00085-7 Ciechanover , A. ( 2005 ). Proteolysis: from the lysosome to ubiquitin and the proteasome . Nat. Rev. Mol. Cell Biol.   6 , 79 - 87 . 10.1038/nrm1552 Ciuffa , R. , Lamark , T. , Tarafder , A. K. , Guesdon , A. , Rybina , S. , Hagen , W. J. H...
Journal Articles
J Cell Sci (2018) 131 (15): jcs215210.
Published: 03 August 2018
... biogenesis and autophagy, are linked by the endolysosomal pathway. Exosomes are cargo-laden extracellular vesicles that arise from endosome-derived multivesicular bodies, and autophagy is a lysosomal-dependent degradation and recycling pathway. Recent studies have revealed shared molecular machinery between...
Journal Articles
J Cell Sci (2018) 131 (11): jcs214536.
Published: 11 June 2018
.... Moreover, by western blotting and double-color APP imaging, we demonstrated that proteasome inhibition precludes APP axonal transport by enhancing its endo-lysosomal delivery, where β-cleavage is induced. Taken together, we found that proteasomes control the distal transport of APP and can re-distribute...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (7): jcs215442.
Published: 06 April 2018
...) caused an accumulation of a massive number of LC3-positive autolysosomes under nutrient-rich conditions, indicating that Rab7 is dispensable for autophagosome–lysosome fusion. Intriguingly, the autolysosomes that had accumulated in Rab7-KO cells matured and disappeared after starvation for a brief period...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs208017.
Published: 29 January 2018
...Feike Hao; Kazuhiko Kondo; Takashi Itoh; Sumiko Ikari; Shigeyuki Nada; Masato Okada; Takeshi Noda ABSTRACT In response to amino acid supply, mTORC1, a master regulator of cell growth, is recruited to the lysosome and activated by the small GTPase Rheb. However, the intracellular localization of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3568–3577.
Published: 15 October 2017
...Miho Oka; Keisuke Hashimoto; Yoshifumi Yamaguchi; Shin-ichiro Saitoh; Yuki Sugiura; Yuji Motoi; Kurara Honda; Yorifumi Kikko; Shinya Ohata; Makoto Suematsu; Masayuki Miura; Kensuke Miyake; Toshiaki Katada; Kenji Kontani ABSTRACT The small GTPase Arl8b localizes primarily to lysosomes and is...
Includes: Supplementary data