... ) * These authors contributed equally to this work 4 1 2007 © The Company of Biologists Limited 2007 2007 Aging Autophagy Lysosomes Lysosomal membrane proteins Proteases Lipid microdomains Autophagy is a conserved intracellular process responsible for the continuous clearance...

... synthesized lysosomal enzymes and of acid occurring specifically at the apical pole, facing the bone compartment. The membranes composing the apical (ruffled-border) and basolateral domains contain topologically restricted antigens, a 100×10 3 M r lysosomal membrane protein and the Na + ,K + -ATPase...