...Hiroshi Yukiura; Kuniyuki Kano; Ryoji Kise; Asuka Inoue; Junken Aoki ABSTRACT Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice...

... ion channel formation to intracellular membrane remodeling. CLIC4 is rapidly recruited to the plasma membrane by lysophosphatidic acid (LPA) and serum, suggesting a possible role for CLIC4 in exocytic–endocytic trafficking. However, the function and subcellular target(s) of CLIC4 remain elusive. Here...

...Mandi M. Murph; Launa A. Scaccia; Laura A. Volpicelli; Harish Radhakrishna Lysophosphatidic acid (LPA) is a serum-borne phospholipid that exerts a pleiotropic range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA 1 /EDG-2,LPA 2 /EDG-4 and LPA 3...

..., and with lysophosphatidic acid, an agent known to activate the small GTP-binding proteins of the Rho family. These data suggest a Rac1-dependent mechanosensory mechanism for phagocytosis, which probably plays an important role in a number of physiological and pathological processes from embryonic development to autoimmune...

... protein by the dbl oncogene product . Nature 354 , 311 – 314 . Kumagai , N. , Morii , N. , Fujisawa , K. , Nemoto , Y. and Narumiya , S. (1993). ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3...