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Keywords: Lumen formation
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Journal Articles
J Cell Sci (2021) 134 (16): jcs259013.
Published: 23 August 2021
... (TRP) family of non-selective cation channels. To test the hypothesis that altered ion channel properties of polycystin-2 compromise its putative role in a control circuit controlling lumen formation of renal tubular structures, we generated a mouse model in which we exchanged the pore loop...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2019) 132 (14): jcs230086.
Published: 15 July 2019
... Dlg1 is localised to the membrane and its importance in mammalian epithelia are unknown. We show that Dlg1 is required in non-transformed mammalian epithelial cells for oriented cell divisions and normal lumen formation. We demonstrate that the MAGUK protein CASK, a membrane-associated scaffold...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 243–259.
Published: 1 January 2017
... cysts. Like ZO-1-deficiency, occludin deletion led to mitotic spindle orientation defects. Single lumen formation required the occludin OCEL domain, which binds to ZO-1. We conclude that ZO-1–occludin interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1812–1822.
Published: 1 June 2009
...Wonshill Koh; Kamakshi Sachidanandam; Amber N. Stratman; Anastasia Sacharidou; Anne M. Mayo; Eric A. Murphy; David A. Cheresh; George E. Davis In this study, we present data showing that Cdc42-dependent lumen formation by endothelial cells (ECs) in three-dimensional (3D) collagen matrices involves...
Includes: Supplementary data