... are largely unknown. We show that VLK is highly expressed in hepatocytes of neonatal mice, but downregulated during adulthood. To determine the role of VLK in liver homeostasis and regeneration, we generated mice with a hepatocyte-specific knockout of the VLK gene ( Pkdcc ). Cultured progenitor cells...

.../397E;mK18-null mice were significantly more resistant to anti-FasAb-induced injury as compared with K18-WT;mK18-null mice (23% vs 57% lethality, respectively; P <0.001). The same applied when the toxin microcystin-LR (MLR) was used to induce liver injury, i.e. lethality of K18-D238/397E;mK18-null...

... liver-enriched transcription factor, HNF4α. Our analyses indicate that SUMOylation plays an important role during hepatocellular differentiation and this is mediated, in part, through regulation of the stability of HNF4α in a ubiquitin-dependent manner. Our study provides a better understanding...

.... , Tucker S. J. , Konstantinou D. K. , Elrick L. J. , Haefner D. , Sigalas C. , Murray G. I. , Goodwin B. , Wright M. C. ( 2005 ). Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent...

...Karen Wallace; Carylyn J. Marek; Stefan Hoppler; Matthew C. Wright Developmentally, the pancreas and liver are closely related and pathological conditions – including elevated glucocorticoid levels – result in the appearance of hepatocytes in the pancreas. The role of the WNT signalling pathway...

...Mari Inada; Antonia Follenzi; Kang Cheng; Manju Surana; Brigid Joseph; Daniel Benten; Sriram Bandi; Hong Qian; Sanjeev Gupta Understanding the biological potential of fetal stem/progenitor cells will help define mechanisms in liver development and homeostasis. We isolated epithelial fetal human...

.... They are characterised by insulin and C-peptide content, the presence of secretory granules that are immunoreactive for insulin, and the ducts exhibit glucose-stimulated insulin secretion. Genetic lineage labelling shows that these β cells arise from the liver domain rather than the pancreas and, by histological study...

... in postnatal neovascularization by generating Sox17 +/- - Sox18 -/- double mutant mice. Whereas Sox18 -/- and Sox17 +/- - Sox18 +/- mice showed no vascular defects, approximately half of the Sox17 +/- - Sox18 -/- pups died before postnatal day 21 (P21). They showed reduced neovascularization in the liver...

... Protein targeting Na + /K + -ATPase Liver In well-polarized epithelia, the plasma membranes are partitioned into the apical and basolateral domains by impermeable tight junctions (the canalicular and lateral/sinusoidal domain in hepatocytes, respectively). This structural design imposes a need...

...Maria Agnese Della Fazia; Marilena Castelli; Daniela Bartoli; Stefania Pieroni; Valentina Pettirossi; Danilo Piobbico; Mariapia Viola-Magni; Giuseppe Servillo The liver has the ability to autonomously regulate growth and mass. Following partial hepatectomy, hormones, growth factors, cytokines...

...Guo-Zhong Tao; Diana M. Toivola; Bihui Zhong; Sara A. Michie; Evelyn Z. Resurreccion; Yoshitaka Tamai; Makoto M. Taketo; M. Bishr Omary Keratin transgenic mouse models and the association of human keratin mutations with liver disease highlight the importance of keratins in protecting the liver from...

...Harmeet Malhi; Adil N. Irani; Singh Gagandeep; Sanjeev Gupta The liver can regenerate itself through the progenitor cells it harbors. Here we demonstrate isolation of epithelial progenitor/stem cells from the fetal human liver, which contains a large number of hepatoblasts. Progenitor liver cells...

... hepatocytes from adult rats with and without two-third partial hepatectomy, which induces hepatic polyploidy. Polyploid hepatocytes showed evidence for oxidative injury with antioxidant depletion, lipid peroxidation and 8-hydroxy-adducts of guanine in nuclear DNA. Liver repopulation assays in intact animals...

...Caroline Clair; Cécile Chalumeau; Thierry Tordjmann; Josiane Poggioli; Christophe Erneux; Geneviève Dupont; Laurent Combettes Glycogenolytic agonists induce coordinated Ca 2+ oscillations in multicellular rat hepatocyte systems as well as in the intact liver. The coordination of intercellular Ca...