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Keywords: Lipid rafts
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Journal Articles
J Cell Sci (2020) 133 (5): jcs237560.
Published: 06 March 2020
... macrophage activation. P2X7 receptor signaling is, in turn, modulated by ectonucleotidases, such as CD39 (also known as ENTPD1), expressed in caveolae and lipid rafts. Here, we examined P2X7 receptor activity and determined impacts on ectonucleotidase localization and function in macrophages primed with...
Journal Articles
J Cell Sci (2014) 127 (11): 2565–2576.
Published: 01 June 2014
... bind effectors. Previous studies have suggested that the binding of Rac1 to membranes requires, and colocalizes with, cholesterol-rich liquid-ordered ( lo ) membrane domains (lipid rafts). Here, we have developed a fluorescence resonance energy transfer (FRET) assay that robustly detects Rac1 membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4280–4291.
Published: 15 December 2010
... Endocytosis Fibronectin Integrin Lipid rafts Staphylococci Pathogenic bacteria and viruses use various endocytic pathways and receptors to enter host cells ( Pizarro-Cerda and Cossart, 2006 ). One major group of eukaryotic receptors involved in the uptake of pathogens are integrins, heterodimeric...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2844–2852.
Published: 15 August 2010
...; we found that occludin knockdown altered the subcellular distribution of caveolin-1 and that partitioning of caveolin into detergent-insoluble lipid rafts was influenced by changing occludin levels. Knockdown of caveolin decreased the cytokine-induced flux increase, whereas the increase in the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1705–1715.
Published: 15 May 2010
...-anchor hybrid with a p24-p23 complex. Density gradient centrifugation revealed co-partitioning of CD59 and p24-p23 into biosynthetically early lipid raft fractions, and CD59 transport to the Golgi was cholesterol dependent. The results suggest that the 24p-23p complex acts as a cargo receptor for GPI...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (9): 1578–1587.
Published: 01 May 2010
... Lipid rafts Mannosyltransferase As in higher eukaryotic cells, phospholipids, sterols and sphingolipids are the major membrane lipid components in yeasts. Sphingolipids are abundant components of eukaryotic plasma membranes, with important functions in bilayer stability, stress adaptation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 529–536.
Published: 15 February 2010
... Intraflagellar transport Lipid rafts Palmitoylation Targeting Cilia and flagella are ancient organelles found in organisms spanning the eukaryotic lineage. The basic structure and biogenesis of cilia and flagella are highly conserved. With few exceptions, these organelles consist of a microtubule...
Journal Articles
J Cell Sci (2010) 123 (4): 544–554.
Published: 15 February 2010
... work ‡ These authors contributed equally to this work § Author for correspondence ( malcolmm@unimelb.edu.au ) 28 10 2009 © 2010. 2010 Flagellum membrane Myristylated protein Jelly-roll β-sheet Lipid rafts Eukaryotic flagella and cilia are highly conserved...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4547–4557.
Published: 15 December 2009
...@lrz.uni-muenchen.de ) * These authors contributed equally to this work 7 10 2009 © The Company of Biologists Limited 2009 2009 Acrosome reaction CaMKII MUPP1 Calcium-regulated exocytosis Spermatozoa PDZ domain Lipid rafts Scaffolding protein Ca 2+ -regulated...
Journal Articles
J Cell Sci (2009) 122 (21): 3966–3972.
Published: 01 November 2009
.... Finally, we speculate on the role of phosphorylation in the regulation of transient anchorage. * Author for correspondence ( frap@med.unc.edu ) 24 8 2009 © The Company of Biologists Limited 2009 2009 Lipid rafts Signal transduction Single-particle tracking GPI-anchored...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (2): 289–299.
Published: 15 January 2009
... integrin and actin. Monosialoganglioside GM1 in the lipid rafts associates with and activates the NGF receptor TrkA, and enhances neurite outgrowth. However, the role of GM1 in laminin-1-induced neurite outgrowth was still unclear. Here, we describe that laminin-1 binds to GM1 through a carbohydrate moiety...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (4): 522–535.
Published: 15 February 2008
...Alina Fridberg; Cheryl L. Olson; Ernesto S. Nakayasu; Kevin M. Tyler; Igor C. Almeida; David M. Engman Sphingolipids and their metabolites have been thought crucial for cell growth and cell cycle progression, membrane and protein trafficking, signal transduction, and formation of lipid rafts...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4486–4498.
Published: 01 November 2006
..., subcellular fractionation experiments showed that TfR1, which spontaneously undergoes endocytosis and recycling, largely distributed to intracellular organelles, whereas TfR2 was mainly associated with the plasma membrane. Given the TfR2 localization in lipid rafts, we tested its capability to activate cell...
Journal Articles
J Cell Sci (2006) 119 (15): 3149–3160.
Published: 01 August 2006
...Duncan T. Browman; Mary E. Resek; Laura D. Zajchowski; Stephen M. Robbins Our laboratory was interested in characterizing the molecular composition of non-caveolar lipid rafts. Thus, we generated monoclonal antibodies to lipid raft proteins of human myelomonocytic cells. Two of these proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (21): 5141–5153.
Published: 01 November 2005
...David R. Taylor; Nicole T. Watt; W. Sumudhu S. Perera; Nigel M. Hooper The cellular prion protein (PrP C ) is essential for the pathogenesis and transmission of prion diseases. Although PrP C is known to be located in detergent-insoluble lipid rafts at the surface of neuronal cells, the mechanism...
Journal Articles
J Cell Sci (2005) 118 (14): 3163–3171.
Published: 15 July 2005
... removed, the cells completed their division and gradually regained Cry1C sensitivity. In comparison to normal cells with 1-2% cell-division frequency, the M-phase arrested cells bound less toxin in binding assays. Moreover, no lipid rafts could be isolated from the membranes of M-phase arrested cells...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (14): 3141–3151.
Published: 15 July 2005
...Anthony I. Magee; Jeremy Adler; Ingela Parmryd The plasma membranes of eukaryotic cells are hypothesised to contain microdomains with distinct lipid and protein composition known as lipid rafts. In T cells, cross-linking of lipid raft components triggers signalling cascades. We show that the T-cell...
Journal Articles
J Cell Sci (2005) 118 (10): 2167–2176.
Published: 15 May 2005
... flotation gradient showed that 40% of the Cx43 floated into these sucrose gradients, whereas none of the Cx43 in ROS cell lysates entered the gradients, suggesting that more Cx43 is associated with lipid rafts in the transfected ROS cells than in lysates derived from untransfected ROS cells. In contrast to...
Journal Articles
J Cell Sci (2005) 118 (10): 2155–2166.
Published: 15 May 2005
... distribution similar to that seen in native cells. * Author for correspondence (e-mail: tamkunmm@lamar.colostate.edu ) 23 2 2005 © The Company of Biologists Limited 2005 2005 Kv channels Membrane trafficking Lipid rafts Ion channel regulation is an important determinant of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (4): 759–769.
Published: 15 February 2005
...-based cytoskeleton structures are known to play a role in these processes. However, mechanisms involving lateral organizations of the plasma membrane remain to be investigated. Here, we demonstrate that a large fraction of platelet lipid rafts specifically associates with the actin cytoskeleton upon...