.... Plasmodium falciparum Lipid droplet Intraerythrocytic stages Lipid metabolism Advanced microscopy 3D FIB-SEM Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 Australian National University http://dx.doi.org/10.13039/501100000995 Australian...

... and external factors. The fission yeast Schizosaccharomyces pombe demonstrates catastrophic mitotic phenotypes due to mutations or drug treatments. One of the factors provoking catastrophic mitosis is a disturbed lipid metabolism, resulting from, for example, mutations in the acetyl-CoA/biotin carboxylase...

... factors found in animals and fungi. In the fission yeast Schizosaccharomyces pombe , they regulate various cellular processes, including cell cycle progression, lipid metabolism and cell adhesion. CSL proteins bind to DNA through their N-terminal Rel-like domain and central β-trefoil domain. Here, we...

... Summary: To study the intricate metabolic network of sphingolipids, minimally modified probes are the tools of choice. We review progress made by using these probes together with the power of click chemistry. Expansion microscopy Lipid metabolism Lipid transport Photoactivation...

... of mitosis, during which the nuclear envelope does not break down. In S. pombe , numerous processes have been identified that contribute to successful completion of mitosis. Notably, perturbations of lipid metabolism can lead to catastrophic mitosis and the ‘cut’ phenotype. It has been suggested...

... no competing or financial interests. © 2022. Published by The Company of Biologists Ltd 2022 Summary: Perilipins coat lipid droplets to regulate their metabolism and signaling, influencing disease development. Lipid droplets Lipid metabolism Lipid signaling Perilipins National...

..., depletion of Snazarus (Snz) led to decreased autophagic flux. Interestingly, we observed altered distribution of Vamp7-positive vesicles with Snz depletion, and the roles of Snz were conserved in human cells. SNX25, the closest human ortholog to Snz, regulates both VAMP8 endocytosis and lipid metabolism...

... neuronal mutants using SRS, specific olfactory neurons were discovered to regulate lipid mobilization in C. elegans , and further screens aided the delineation of the neuroendocrine signaling pathway that links olfactory perception and peripheral lipid metabolism ( Mutlu et al., 2020...

.... and Siniossoglou , S. ( 2015 ). Lipid droplet-organelle interactions: emerging roles in lipid metabolism . Curr. Opin. Cell Biol.   35 , 91 - 97 . 10.1016/j.ceb.2015.04.017 Barneda , D. , Planas-Iglesias , J. , Gaspar , M. L. , Mohammadyani , D. , Prasannan , S. , Dormann , D...

... utilization, independently of lipophagy. Lipid metabolism Lipid droplet Diacylglycerol Vacuole homeostasis ESCRT TORC1 Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen Bundesministerium für Gesundheit 10.13039/501100003107...

... droplet fate. Endoplasmic reticulum Lipid droplets Lipid metabolism Organelle biogenesis Organelle diversification Emulsion physics Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677 Programme Emergence de la Ville de Paris...

... interests. © 2014. Published by The Company of Biologists Ltd 2014 Nitric oxide Lipid metabolism Mitochondrial biogenesis Mitochondrial metabolism Nitric oxide (NO) is a free radical molecule that is physiologically synthesised in a tightly controlled manner by a family of cytochrome...

.... , Rabouille   C. , Rørth   P. , Ephrussi   A. , Vanzo   N. F. ( 2003 ). Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism.   Mech. Dev.   120 , 1071 – 1081 . 10.1016/S0925-4773(03)00158-8 Tian   Y. , Bi   J. , Shui   G. , Liu   Z. , Xiang   Y. , Liu   Y...

...-hyogo.ac.jp ) 15 10 2012 © 2012. Published by The Company of Biologists Ltd 2012 Lipid droplet Lipolysis Lipid metabolism Fatty acid CARS microscopy Excessive lipid accumulation in adipocytes is a central feature of obesity and metabolic syndrome. Lipid droplets (LDs) were long...

... and pathological processes. In contrast to the established role of HIF-1 in glucose metabolism, the involvement of HIFs and the molecular mechanisms concerning the effects of hypoxia on lipid metabolism are poorly characterized. Here, we report that exposure of human cells to hypoxia causes accumulation...

... et al., 1990 ; Segref et al., 1997 ; Tseng et al., 1998 ), an mRNA-export defect cannot be the underlying cause of the NE and lipid metabolism abnormalities seen in apq12 Δ and brr6-1 cells. Defects in NPCs and the NE are seen in some strains that lack a non-essential nucleoporin or produce...

... such as diabetes, obesity and cancer. In Drosophila , studies have recently revealed that different subcellular pools of activated, phosphorylated Akt can modulate different IIS-dependent processes. For example, a specific pool of activated Akt within the cytoplasm alters aspects of lipid metabolism, a process...

... and microvesicular cell phenotypes resulting from triglyceride accumulation in lipid-metabolizing tissues. However, the molecular mechanisms underlying abnormal fat distribution induced by mitochondrial dysfunction remain poorly understood. In this study, we show that inhibition of respiratory complex III...