.... Plasmodium falciparum Lipid droplet Intraerythrocytic stages Lipid metabolism Advanced microscopy 3D FIB-SEM Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 Australian National University http://dx.doi.org/10.13039/501100000995 Australian...

... and external factors. The fission yeast Schizosaccharomyces pombe demonstrates catastrophic mitotic phenotypes due to mutations or drug treatments. One of the factors provoking catastrophic mitosis is a disturbed lipid metabolism, resulting from, for example, mutations in the acetyl-CoA/biotin carboxylase...

... factors found in animals and fungi. In the fission yeast Schizosaccharomyces pombe , they regulate various cellular processes, including cell cycle progression, lipid metabolism and cell adhesion. CSL proteins bind to DNA through their N-terminal Rel-like domain and central β-trefoil domain. Here, we...

... Summary: To study the intricate metabolic network of sphingolipids, minimally modified probes are the tools of choice. We review progress made by using these probes together with the power of click chemistry. Expansion microscopy Lipid metabolism Lipid transport Photoactivation...

... of mitosis, during which the nuclear envelope does not break down. In S. pombe , numerous processes have been identified that contribute to successful completion of mitosis. Notably, perturbations of lipid metabolism can lead to catastrophic mitosis and the ‘cut’ phenotype. It has been suggested...

... no competing or financial interests. © 2022. Published by The Company of Biologists Ltd 2022 Summary: Perilipins coat lipid droplets to regulate their metabolism and signaling, influencing disease development. Lipid droplets Lipid metabolism Lipid signaling Perilipins National...

..., depletion of Snazarus (Snz) led to decreased autophagic flux. Interestingly, we observed altered distribution of Vamp7-positive vesicles with Snz depletion, and the roles of Snz were conserved in human cells. SNX25, the closest human ortholog to Snz, regulates both VAMP8 endocytosis and lipid metabolism...

... in the field. Label-free imaging Coherent Raman scattering microscopy Lipid droplet Lipid metabolism Genetic screens Lipid droplets (LDs) are cellular organelles that are highly specialized; they contain a hydrophobic core of neutral lipids, triacylglycerol and/or sterol ester, enclosed...

.... Lipid droplet Molecular tethers Contact sites Protein targeting Lipid metabolism Multifunctional lipid droplets Our knowledge of lipid droplet (LD) function has expanded strikingly in the past decades, driven by numerous genome-wide screens of LDs ( Box 1 ), which have identified hundreds...

... utilization, independently of lipophagy. Lipid metabolism Lipid droplet Diacylglycerol Vacuole homeostasis ESCRT TORC1 Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen Bundesministerium für Gesundheit 10.13039/501100003107...

... reticulum Lipid droplets Lipid metabolism Organelle biogenesis Organelle diversification Emulsion physics Summary: We discuss the intriguing diversification of lipid droplets between and within cells and propose the early steps of lipid droplet biogenesis to determine the later lipid droplet...

.... , Wolf   G. , Keilhoff   G. ( 2006 ). Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolism.   FASEB J.   20 , 145 – 147 . Smith   B. K. , Mukai   K. , Lally   J. S. , Maher   A. C. , Gurd   B. J. , Heigenhauser   G. J...

.... , Rabouille   C. , Rørth   P. , Ephrussi   A. , Vanzo   N. F. ( 2003 ). Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism.   Mech. Dev.   120 , 1071 – 1081 . 10.1016/S0925-4773(03)00158-8 Tian   Y. , Bi   J. , Shui   G. , Liu   Z. , Xiang   Y. , Liu   Y...

... protein 5 in lipid metabolism.   Biol. Pharm. Bull.   33 , 342 – 345 . 10.1248/bpb.33.342 Yamaguchi   T. , Omatsu   N. , Matsushita   S. , Osumi   T. ( 2004 ). CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization...

... and pathological processes. In contrast to the established role of HIF-1 in glucose metabolism, the involvement of HIFs and the molecular mechanisms concerning the effects of hypoxia on lipid metabolism are poorly characterized. Here, we report that exposure of human cells to hypoxia causes accumulation...

... not shown). The composition of these structures is not known. The extensive white expansions of the NE and ER (white arrows in Fig. 3C ) might be lipids, reflecting abnormalities in lipid metabolism (see below). These were observed in approximately 30% of thin sections of brr6-1 cells, but in only about...

... such as diabetes, obesity and cancer. In Drosophila , studies have recently revealed that different subcellular pools of activated, phosphorylated Akt can modulate different IIS-dependent processes. For example, a specific pool of activated Akt within the cytoplasm alters aspects of lipid metabolism, a process...

... and microvesicular cell phenotypes resulting from triglyceride accumulation in lipid-metabolizing tissues. However, the molecular mechanisms underlying abnormal fat distribution induced by mitochondrial dysfunction remain poorly understood. In this study, we show that inhibition of respiratory complex III...