... of mitosis, during which the nuclear envelope does not break down. In S. pombe , numerous processes have been identified that contribute to successful completion of mitosis. Notably, perturbations of lipid metabolism can lead to catastrophic mitosis and the ‘cut’ phenotype. It has been suggested...

... no competing or financial interests. © 2022. Published by The Company of Biologists Ltd 2022 Summary: Perilipins coat lipid droplets to regulate their metabolism and signaling, influencing disease development. Lipid droplets Lipid metabolism Lipid signaling Perilipins National...

..., depletion of Snazarus (Snz) led to decreased autophagic flux. Interestingly, we observed altered distribution of Vamp7-positive vesicles with Snz depletion, and the roles of Snz were conserved in human cells. SNX25, the closest human ortholog to Snz, regulates both VAMP8 endocytosis and lipid metabolism...

... chemical histopathology . Biomed. Opt. Express 10 , 4329 . 10.1364/BOE.10.004329 Lin , C.-C. J. and Wang , M. C. ( 2017 ). Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling . Nat. Cell Biol. 19 , 550 - 557 . 10.1038/ncb3515 Lincoln...

... in yeast ( Valm et al., 2017 ), is emerging as a key feature of lipid metabolism and biology ( Welte and Gould, 2017 ; Krahmer et al., 2018 ; Rambold et al., 2015 ; Joshi et al., 2018 ; Hariri et al., 2018 ; Wang et al., 2018a ). The establishment of diverse LD–organelle contact sites has profound...

... ). In addition, it is now well-accepted that mTORC1 regulates hepatic lipid metabolism via lipin-1 and the SREBP transcriptional network ( Lamming and Sabatini, 2013 ; Peterson et al., 2011 ). Direct crosstalk between lysosomes and LDs to coordinate their status and dynamics, equivalent to the mechanism...

... droplet fate. Endoplasmic reticulum Lipid droplets Lipid metabolism Organelle biogenesis Organelle diversification Emulsion physics The storage of lipids is a universal feature of cells and organisms, which evolved as a mechanism that allowed survival by buffering energy fluctuations...

... The authors declare no competing interests. © 2014. Published by The Company of Biologists Ltd 2014 Nitric oxide Lipid metabolism Mitochondrial biogenesis Mitochondrial metabolism Nitric oxide (NO) is a free radical molecule that is physiologically synthesised in a tightly controlled...

... ) 15 02 2013 © 2013. Published by The Company of Biologists Ltd 2013 Lipid droplets Organelle clustering Organelle positioning Lipid metabolism Drosophila melanogaster The storage of lipids as a reservoir for energy rich compounds and metabolic building blocks is important...

...-hyogo.ac.jp ) 15 10 2012 © 2012. Published by The Company of Biologists Ltd 2012 Lipid droplet Lipolysis Lipid metabolism Fatty acid CARS microscopy Excessive lipid accumulation in adipocytes is a central feature of obesity and metabolic syndrome. Lipid droplets (LDs) were long...

... and pathological processes. In contrast to the established role of HIF-1 in glucose metabolism, the involvement of HIFs and the molecular mechanisms concerning the effects of hypoxia on lipid metabolism are poorly characterized. Here, we report that exposure of human cells to hypoxia causes accumulation...

... of these structures is not known. The extensive white expansions of the NE and ER (white arrows in Fig. 3C ) might be lipids, reflecting abnormalities in lipid metabolism (see below). These were observed in approximately 30% of thin sections of brr6-1 cells, but in only about 5% of sections of wild-type cells...

... such as diabetes, obesity and cancer. In Drosophila , studies have recently revealed that different subcellular pools of activated, phosphorylated Akt can modulate different IIS-dependent processes. For example, a specific pool of activated Akt within the cytoplasm alters aspects of lipid metabolism, a process...

... and microvesicular cell phenotypes resulting from triglyceride accumulation in lipid-metabolizing tissues. However, the molecular mechanisms underlying abnormal fat distribution induced by mitochondrial dysfunction remain poorly understood. In this study, we show that inhibition of respiratory complex III...

...JAN TOMMASSEN; TRUUS DE VRIJE; HANS DE COCK; DIRK BOSCH; BEN DE KRUIJFF Summary Several models for the transport of proteins across membranes predict a role for lipids. If these models are correct, then alterations in lipid metabolism may affect protein export and vice versa . We are investigating...