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Keywords: Lipid droplets
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Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (7): jcs259092.
Published: 14 April 2022
...Kazuki Ueda; Matthew N. Anderson-Baron; Julie Haskins; Sarah C. Hughes; Andrew J. Simmonds ABSTRACT Both peroxisomes and lipid droplets regulate cellular lipid homeostasis. Direct inter-organellar contacts as well as novel roles for proteins associated with peroxisome or lipid droplets occur when...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259501.
Published: 9 March 2022
...Charles P. Najt; Mahima Devarajan; Douglas G. Mashek ABSTRACT Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259253.
Published: 25 February 2022
...Toyoshi Fujimoto ABSTRACT Lipid droplets (LDs) in the cytoplasm are formed in the endoplasmic reticulum (ER) and are connected with various organelles, both structurally and functionally. This is in contrast to LDs in the nucleus, which are separated from organelles in the cytoplasm. How nuclear...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (5): jcs259220.
Published: 2 November 2021
...Pawel Leznicki; Hayden O. Schneider; Jada V. Harvey; Wei Q. Shi; Stephen High ABSTRACT Membrane proteins destined for lipid droplets (LDs), a major intracellular storage site for neutral lipids, are inserted into the endoplasmic reticulum (ER) and then trafficked to LDs where they reside...
Includes: Supplementary data
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J Cell Sci (2018) 131 (10): jcs212753.
Published: 16 May 2018
... of the endoplasmic reticulum (ER) that is also present at lipid droplets. Manipulations of isoform 2 levels cause rapid ER stress, likely through deregulation of lipid homeostasis, and lead to cell death. Our work highlights how alternative isoforms provide functional expansion of DUBs and sets directions for future...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2017) 130 (18): 3141–3157.
Published: 15 September 2017
...Peter J. Thul; Kirsten Tschapalda; Petra Kolkhof; Abdou Rachid Thiam; Monika Oberer; Mathias Beller ABSTRACT Lipid droplets (LDs) are the principal organelles of lipid storage. They consist of a hydrophobic core of storage lipids, surrounded by a phospholipid monolayer with proteins attached. While...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 315–324.
Published: 15 January 2017
...Abdou Rachid Thiam; Mathias Beller ABSTRACT Lipid droplets are the universal cellular organelles for the transient or long-term storage of lipids. The number, size and composition of lipid droplets vary greatly within cells in a homogenous population as well as in different cell types...
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J Cell Sci (2014) 127 (9): 1857–1867.
Published: 1 May 2014
... of deacetylase, kinase and phosphatase signaling activities. The localized signaling gradients established by targeted O -GlcNAc cycling influence many important cellular processes, including lipid droplet remodeling, mitochondrial functioning, epigenetic control of gene expression and proteostasis...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2014) 127 (6): 1214–1228.
Published: 15 March 2014
...Chao-Wen Wang; Yu-Hsuan Miao; Yi-Shun Chang ABSTRACT The human congenital generalized lipodystrophy type 2 protein seipin (Fld1 in budding yeast) controls lipid droplet (LD) size through an unknown mechanism. Here, we report that deletion of yeast LDB16/YCL005W , similar to deletion of FLD1...
Includes: Supplementary data
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In collection:
Lipid Biology
J Cell Sci (2012) 125 (12): 2930–2939.
Published: 15 June 2012
...Chao-Wen Wang; Shu-Chuan Lee Summary Lipid droplets (LDs) are central organelles for maintaining lipid homeostasis. However, how cells control the size and number of LDs remains largely unknown. Herein, we report that Ubx2, a UBX-domain-containing protein involved in endoplasmic reticulum (ER...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2011) 124 (16): 2851–2860.
Published: 15 August 2011
... accumulates on the surface of nascent lipid droplets with perilipin-2; both of these proteins are stabilized by proteasome inhibition. We show that selective downregulation of OGA-S results in global proteasome inhibition and the striking accumulation of ubiquitinylated proteins. OGA-S knockdown increased...
Includes: Supplementary data
Journal Articles