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Keywords: Lipid droplet
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Journal Articles
In collection:
Imaging
J Cell Sci (2022) 135 (5): jcs252353.
Published: 11 May 2021
...Tao Chen; Ahmet Yavuz; Meng C. Wang ABSTRACT Lipid droplets (LDs) are lipid-rich organelles universally found in most cells. They serve as a key energy reservoir, actively participate in signal transduction and dynamically communicate with other organelles. LD dysfunction has been associated...
Journal Articles
J Cell Sci (2020) 133 (21): jcs248526.
Published: 05 November 2020
...Wei Sheng Yap; Peter Shyu, Jr; Maria Laura Gaspar; Stephen A. Jesch; Charlie Marvalim; William A. Prinz; Susan A. Henry; Guillaume Thibault ABSTRACT Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs230169.
Published: 17 June 2019
... fattening on health. Highly related to this clinical problem, studies at the cellular and molecular level are focused on the fundamental mechanism of lipid handling in dedicated lipid droplet (LD) organelles. This Review briefly summarizes how views on LD functions have evolved from those of a specialized...
Journal Articles
J Cell Sci (2019) 132 (6): jcs223016.
Published: 18 March 2019
... peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids. Lipid droplet localization of exogenously expressed and endogenous human Far1 was observed by fluorescence microscopy under conditions of increased triglyceride synthesis in tissue culture cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs217042.
Published: 09 January 2019
...Susan Lassen; Cordula Grüttner; Van Nguyen-Dinh; Eva Herker ABSTRACT In hepatocytes, PLIN2 is the major protein coating lipid droplets (LDs), an organelle the hepatitis C virus (HCV) hijacks for virion morphogenesis. We investigated the consequences of PLIN2 deficiency on LDs and on HCV infection...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs217331.
Published: 21 August 2018
..., although cwh43 cells apparently consumed glucose in the culture medium. Furthermore, we found that cwh43 mutant cells had elevated levels of triacylglycerols (TGs) and coenzyme A, and that they accumulated lipid droplets. Notably, TG biosynthesis was required to maintain cell division in the cwh43 mutant...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2018) 131 (11): jcs213876.
Published: 11 June 2018
...Sarah Ouahoud; Mitchell D. Fiet; Fernando Martínez-Montañés; Christer S. Ejsing; Oliver Kuss; Michael Roden; Daniel F. Markgraf ABSTRACT Lipid droplets (LDs) store neutral lipids and are integrated into a cellular metabolic network that relies on functional coupling with various organelles. Factors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3223–3238.
Published: 01 September 2015
... lipid metabolism. We found increased lipid droplet numbers in BALB/c 3T3 cell lines stably expressing TPD52, compared with control and TPD52L1-expressing cell lines. TPD52-expressing 3T3 cells showed increased fatty acid storage in triglyceride (from both de novo synthesis and uptake) and formed greater...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4602–4619.
Published: 01 November 2014
...Safa Lucken-Ardjomande Häsler; Yvonne Vallis; Helen E. Jolin; Andrew N. McKenzie; Harvey T. McMahon ABSTRACT Lipid droplets are found in all cell types. Normally present at low levels in the brain, they accumulate in tumours and are associated with neurodegenerative diseases. However, little...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4794–4805.
Published: 15 October 2013
...Samuel Bouvet; Marie-Pierre Golinelli-Cohen; Vincent Contremoulins; Catherine L. Jackson Summary Lipid droplet metabolism and secretory pathway trafficking both require activation of the Arf1 small G protein. The spatiotemporal regulation of Arf1 activation is mediated by guanine nucleotide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6127–6136.
Published: 15 December 2012
...Takeshi Hashimoto; Hiroki Segawa; Masanari Okuno; Hideaki Kano; Hiro-o Hamaguchi; Tokuko Haraguchi; Yasushi Hiraoka; Shiho Hasui; Tomohiro Yamaguchi; Fumiko Hirose; Takashi Osumi Summary The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3568–3577.
Published: 01 August 2012
...Junfeng Bi; Yanhui Xiang; Haiyang Chen; Zhonghua Liu; Sebastian Grönke; Ronald P. Kühnlein; Xun Huang Summary Lipid droplets are the main lipid storage sites in cells. Lipid droplet homeostasis is regulated by the surface accessibility of lipases. Mammalian adipose triglyceride lipase (ATGL...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3894–3904.
Published: 15 November 2011
...Heimo Wolinski; Dagmar Kolb; Sandra Hermann; Roman I. Koning; Sepp D. Kohlwein Malfunctions of processes involved in cellular lipid storage and mobilization induce the pathogenesis of prevalent human diseases such as obesity, type 2 diabetes and atherosclerosis. Lipid droplets are the main lipid...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3247–3253.
Published: 01 October 2011
...Tanya D. Russell; Jerome Schaack; David J. Orlicky; Carol Palmer; Benny Hung-Junn Chang; Lawrence Chan; James L. McManaman Milk lipids originate by secretion of triglyceride-rich cytoplasmic lipid droplets (CLDs) from mammary epithelial cells. Adipophilin (ADPH)/Plin2, a member of the perilipin...
Journal Articles
J Cell Sci (2009) 122 (20): 3694–3702.
Published: 15 October 2009
...John K. Zehmer; René Bartz; Blaine Bisel; Pingsheng Liu; Joachim Seemann; Richard G. W. Anderson Lipid droplets are sites of neutral lipid storage thought to be actively involved in lipid homeostasis. A popular model proposes that droplets are formed in the endoplasmic reticulum (ER) by a process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1834–1841.
Published: 01 June 2009
...Krishnakant G. Soni; Gonzalo A. Mardones; Rachid Sougrat; Elena Smirnova; Catherine L. Jackson; Juan S. Bonifacino Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (14): 2415–2422.
Published: 15 July 2008
...Yuki Ohsaki; Jinglei Cheng; Michitaka Suzuki; Akikazu Fujita; Toyoshi Fujimoto Apolipoprotein B-100 (ApoB) is a major component of very-low-density lipoproteins, and is deposited in a region around lipid droplets (LDs) called the `ApoB-crescent'. The ApoB-crescent is thought to be related to ApoB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1852–1860.
Published: 01 June 2008
...John K. Zehmer; René Bartz; Pingsheng Liu; Richard G. W. Anderson AAM-B is a putative methyltransferase that is a resident protein of lipid droplets. We have identified an N-terminal 28 amino acid hydrophobic sequence that is necessary and sufficient for targeting the protein to droplets...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (12): 2601–2611.
Published: 15 June 2005
...Shintaro Ozeki; Jinglei Cheng; Kumi Tauchi-Sato; Naoya Hatano; Hisaaki Taniguchi; Toyoshi Fujimoto Lipid droplets (LDs) are organelles that store neutral lipids, but their regulatory mechanism is not well understood. In the present study, we identified Rab18 as an LD component of HepG2 cells...