...Pragya Chandrakar; Anuradha Seth; Ankita Rani; Mukul Dutta; Naveen Parmar; Albert Descoteaux; Susanta Kar ABSTRACT Notch signaling governs crucial aspects of intercellular communication spanning antigen-presenting cells and T-cells. In this study, we investigate how Leishmania donovani takes...

...Moumita Basu; Purnima Gupta; Ananya Dutta; Kuladip Jana; Anindita Ukil ABSTRACT Intracellular survival of Leishmania donovani demands rapid production of host ATP for its sustenance. However, a gradual decrease in intracellular ATP in spite of increased glycolysis suggests ATP efflux during...

... Leishmania donovani . However, we also found that, during the late phase of infection, PD-1 expression was significantly increased without activating host cell apoptosis; here we show that inhibition of PD-1 led to markedly decreased parasite survival, along with increased production of TNFα, IL-12, reactive...

...Thierry Lang; Raymond Hellio; Paul M. Kaye; Jean-Claude Antoine ABSTRACT Leishmania donovani amastigotes, the etiological agents of visceral leishmaniasis, are obligate intracellular parasites residing in membrane-bound compartments of macrophages called parasitophorous vacuoles (PV). The study...