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Keywords: Lamins
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Journal Articles
J Cell Sci jcs.262161.
Published: 29 January 2025
... rearrangements, and DNA damage. Nuclear blebs (i.e., herniations of the nuclear envelope) have been induced by (1) nuclear compression, (2) nuclear migration (e.g., cancer metastasis), (3) actin contraction, (4) lamin mutation or depletion, and (5) heterochromatin enzyme inhibition. Recent work has shown...
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In collection:
Cytoskeleton
J Cell Sci (2021) 134 (6): jcs256156.
Published: 22 March 2021
...Rafael Kronenberg-Tenga; Meltem Tatli; Matthias Eibauer; Wei Wu; Ji-Yeon Shin; Gisèle Bonne; Howard J. Worman; Ohad Medalia ABSTRACT The LMNA gene encodes the A-type lamins, which polymerize into ∼3.5-nm-thick filaments and, together with B-type lamins and associated proteins, form the nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (13): 2087–2096.
Published: 1 July 2017
...Nana Naetar; Simona Ferraioli; Roland Foisner ABSTRACT Nuclear lamins are components of the peripheral lamina that define the mechanical properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also to the nuclear interior, but the regulation and specific functions...
Journal Articles
J Cell Sci (2015) 128 (19): 3607–3620.
Published: 1 October 2015
...Monika Zwerger; Heidi Roschitzki-Voser; Reto Zbinden; Celine Denais; Harald Herrmann; Jan Lammerding; Markus G. Grütter; Ohad Medalia ABSTRACT Lamins are intermediate filament proteins that form a fibrous meshwork, called the nuclear lamina, between the inner nuclear membrane and peripheral...
Includes: Supplementary data
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J Cell Sci (2012) 125 (9): 2087–2093.
Published: 1 May 2012
...Chin Yee Ho; Jan Lammerding Cancer cells are often characterized by abnormally shaped nuclei, resembling those of lamin-deficient cells ( Dey, 2009 ; Friedl et al., 2011 ). Recently, changes in lamin expression have been reported in a variety of cancers, frequently correlating with tumorigenic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (4): 536–548.
Published: 15 February 2008
... termini reside cyto- or nucleoplasmically. Nuclear envelope targeting of LUMA mainly depends on the membrane spans. LUMA's transmembrane domains also promote homooligomerization. LUMA binds A- and B-type lamins and depends on A-type lamins for its INM localization. Furthermore, it interacts with emerin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 737–747.
Published: 1 March 2007
...Nana Naetar; Sabine Hutter; Daniela Dorner; Thomas Dechat; Barbara Korbei; Josef Gotzmann; Hartmut Beug; Roland Foisner Lamina-associated polypeptide 2α (LAP2α) is a nuclear protein dynamically associating with chromatin during the cell cycle. In addition, LAP2α interacts with A-type lamins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3265–3272.
Published: 15 August 2006
...Antonio E. Rusiñol; Michael S. Sinensky Three mammalian nuclear lamin proteins, lamin B 1 , lamin B 2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis...
Journal Articles
J Cell Sci (2005) 118 (24): 5797–5810.
Published: 15 December 2005
...Andreas Brachner; Siegfried Reipert; Roland Foisner; Josef Gotzmann The LEM (lamina-associated polypeptide–emerin–MAN1) domain is a motif shared by a group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the nucleoplasm. The LEM domain mediates binding to a DNA-crosslinking...
Journal Articles
J Cell Sci (2005) 118 (2): 409–420.
Published: 15 January 2005
...Ewa Markiewicz; Maria Ledran; Christopher J. Hutchison Changes in the expression and distribution of nuclear lamins were investigated during C2C12 myoblast differentiation. The expression of most lamins was unchanged during myogenesis. By contrast, lamin-B 2 expression increased and LAP2α...
Journal Articles
J Cell Sci (2004) 117 (25): 6095–6104.
Published: 1 December 2004
...Thorsten Ralle; Christine Grund; Werner W. Franke; Reimer Stick The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the nuclear envelope. Association of lamins with the inner nuclear membrane is mediated by specific modifications in the CaaX motif at their C-termini. B-type...
Journal Articles
J Cell Sci (2004) 117 (25): 6117–6128.
Published: 1 December 2004
...Thomas Dechat; Andreas Gajewski; Barbara Korbei; Daniel Gerlich; Nathalie Daigle; Tokuko Haraguchi; Kazuhiro Furukawa; Jan Ellenberg; Roland Foisner Lamina-associated polypeptide (LAP) 2α is a LEM (lamina-associated polypeptide emerin MAN1) family protein associated with nucleoplasmic A-type lamins...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (3): 571–583.
Published: 1 February 2003
... for caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved differently in Jurkat T and HeLa cells, suggesting that different sets of caspases are activated in these cell lines. The normal diffuse intranuclear distribution of NuMA changed...
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J Cell Sci (1993) 106 (1): 431–439.
Published: 1 September 1993
...A. Mínguez; S. Moreno Díaz de la Espina ABSTRACT We have used polyclonal and monoclonal antibodies against different lamins from vertebrates, and the IFA antibody recognizing all kinds of intermediate filament proteins, to investigate the lamins of the nuclear matrix of Allium cepa meristematic...
Journal Articles
Journal Articles
J Cell Sci (1991) 98 (1): 37–43.
Published: 1 January 1991
... fulllength cDNA nature. The open reading frame of PN1 encodes a rather hydrophilic and highly charged 34.5 × 10 3 M r polypeptide comprising short but apparently significant strings of 100% sequence identity with the major nuclear lamina polypeptides lamins A/C and lamin B. Restriction enzyme mapping of PN1...