...Rafael Kronenberg-Tenga; Meltem Tatli; Matthias Eibauer; Wei Wu; Ji-Yeon Shin; Gisèle Bonne; Howard J. Worman; Ohad Medalia ABSTRACT The LMNA gene encodes the A-type lamins, which polymerize into ∼3.5-nm-thick filaments and, together with B-type lamins and associated proteins, form the nuclear...

...Nana Naetar; Simona Ferraioli; Roland Foisner ABSTRACT Nuclear lamins are components of the peripheral lamina that define the mechanical properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also to the nuclear interior, but the regulation and specific functions...

...Monika Zwerger; Heidi Roschitzki-Voser; Reto Zbinden; Celine Denais; Harald Herrmann; Jan Lammerding; Markus G. Grütter; Ohad Medalia ABSTRACT Lamins are intermediate filament proteins that form a fibrous meshwork, called the nuclear lamina, between the inner nuclear membrane and peripheral...

... by The Company of Biologists Ltd 2014 Centenarian Prelamin A Lamins 53BP1 Chromatin organisation Rapamycin Profound changes in nuclear organisation and chromatin remodelling occur in senescent cells. Indeed, heterochromatin foci (senescence-associated heterochromatin foci) or loss...

...Chin Yee Ho; Jan Lammerding Lamins were first recognized as components of the nuclear matrix; it is now apparent that they convey a multitude of functions, ranging from structural support of the nucleus to facilitating chromatin organization, gene regulation and DNA repair (reviewed by Dechat...

... termini reside cyto- or nucleoplasmically. Nuclear envelope targeting of LUMA mainly depends on the membrane spans. LUMA's transmembrane domains also promote homooligomerization. LUMA binds A- and B-type lamins and depends on A-type lamins for its INM localization. Furthermore, it interacts with emerin...

...Nana Naetar; Sabine Hutter; Daniela Dorner; Thomas Dechat; Barbara Korbei; Josef Gotzmann; Hartmut Beug; Roland Foisner Lamina-associated polypeptide 2α (LAP2α) is a nuclear protein dynamically associating with chromatin during the cell cycle. In addition, LAP2α interacts with A-type lamins...

...Antonio E. Rusiñol; Michael S. Sinensky Three mammalian nuclear lamin proteins, lamin B 1 , lamin B 2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis...

...Andreas Brachner; Siegfried Reipert; Roland Foisner; Josef Gotzmann The LEM (lamina-associated polypeptide–emerin–MAN1) domain is a motif shared by a group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the nucleoplasm. The LEM domain mediates binding to a DNA-crosslinking...

...Ewa Markiewicz; Maria Ledran; Christopher J. Hutchison Changes in the expression and distribution of nuclear lamins were investigated during C2C12 myoblast differentiation. The expression of most lamins was unchanged during myogenesis. By contrast, lamin-B 2 expression increased and LAP2α...

...Thorsten Ralle; Christine Grund; Werner W. Franke; Reimer Stick The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the nuclear envelope. Association of lamins with the inner nuclear membrane is mediated by specific modifications in the CaaX motif at their C-termini. B-type...

...Thomas Dechat; Andreas Gajewski; Barbara Korbei; Daniel Gerlich; Nathalie Daigle; Tokuko Haraguchi; Kazuhiro Furukawa; Jan Ellenberg; Roland Foisner Lamina-associated polypeptide (LAP) 2α is a LEM (lamina-associated polypeptide emerin MAN1) family protein associated with nucleoplasmic A-type lamins...

... for caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved differently in Jurkat T and HeLa cells, suggesting that different sets of caspases are activated in these cell lines. The normal diffuse intranuclear distribution of NuMA changed...

...Cecilia Östlund; Gisèle Bonne; Ketty Schwartz; Howard J. Worman Autosomal dominant Emery-Dreifuss muscular dystrophy is caused by mutations in the LMNA gene, which encodes lamin A and lamin C. Mutations in this gene also give rise to limb girdle muscular dystrophy type 1B, dilated cardiomyopathy...

...O. Anthony Vaughan; Mauricio Alvarez-Reyes; Joanna M. Bridger; Jos L. V. Broers; Frans C. S. Ramaekers; Manfred Wehnert; Glen E. Morris; William G. F. Whitfield; Christopher J. Hutchison Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro...

... novel keratin. 23 5 2001 © The Company of Biologists Limited 2001 2001 Human genome intermediate filament proteins keratins lamins neurofilament proteins pseudogenes disease The increase in specific cell types represents one hallmark of metazoan evolution...

... of the envelope and the relationship between nuclear pores, lamina fibres and pore-connecting fibrils. The lamin proteins that constitute the lamina resemble intermediate filament proteins, and assemble and disassemble during mitosis in response to phosphorylation. Lamins have been expressed in E. coli...