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Keywords: Lamellipodium
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Journal Articles
J Cell Sci (2021) 134 (23): jcs258983.
Published: 06 December 2021
...., 2012 ). The line colour of the ROI was encoded to represent four morphologically distinct precursor types – growth cone splitting (blue), filopodium (red), lamellipodium/actin wave (green) and a mixed type (yellow). In a second round of analysis, branch type classifications were quality controlled...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs239020.
Published: 09 April 2020
... and their subsequent stabilization by nascent adhesions. The actin-binding protein lamellipodin (Lpd) is thought to play a critical role in lamellipodium protrusion, by delivering Ena/VASP proteins onto the growing plus ends of actin filaments and by interacting with the WAVE regulatory complex, an activator...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1922–1933.
Published: 15 May 2015
.... 29 9 2014 16 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 VICKZ Igf2bp protein Intracellular RNA localization Phagokinetic assay Cell movement Lamellipodium Cofilin The family of VICKZ RNA-binding proteins has been implicated in regulating several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3414–3427.
Published: 15 October 2011
... polymerisation of branched actin networks. In order to identify new SWC regulators, we conducted a screen in Drosophila cells combining proteomics with functional genomics. This screen identified Clathrin heavy chain (CHC) as a protein that binds to the SWC and whose depletion affects lamellipodium formation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (3): 425–432.
Published: 01 February 2006
... effectively counteract each other. Inhibition of RhoA by C3 transferase increases membrane ruffling ( Rottner et al., 1999 ) and locally RhoA effectively antagonises Rac-dependent lamellipodium formation ( Worthylake and Burridge, 2003 ). In neutrophils establishing polarity, there is high Rac and low Rho...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (12): 2613–2623.
Published: 15 June 2005
... to direct the correct spatial activation of membrane protrusion. * Author for correspondence (e-mail: jtp@virginia.edu ) 16 3 2005 © The Company of Biologists Limited 2005 2005 FAK Cell polarity Cell migration Lamellipodium The migration of cells is essential for a wide...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (16): 3593–3604.
Published: 15 July 2004
.... Actin-bundling activity Actin-stabilizing activity Caldesmon Focal adhesion Wound-healing assay Lamellipodium © The Company of Biologists Limited 2004 2004 10 3 2004 * Author for correspondence (e-mail: jim-lin@uiowa.edu ) In early studies, two opposing theories...
Journal Articles
J Cell Sci (2004) 117 (1): 85–92.
Published: 01 January 2004
... adhesions Actin Vinculin Lamellipodium Cell migration is important to many crucial biological functions such as embryogenesis, immune responses, wound healing and cancer metastasis ( Stossel, 1993 ). The process involves a number of well-orchestrated steps including protrusion, adhesion...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (9): 1877–1882.
Published: 01 May 2002
... architecture. * Author for correspondence (e-mail: jvsmall@imb.oeaw.ac.at ) 12 2 2002 © The Company of Biologists Limited 2002 2002 Actin Cytoskeleton Lamellipodium Motility Cryo-electron microscopy The first sign of movement of a eukaryotic cell is the protrusion...