...., 2012 ). The line colour of the ROI was encoded to represent four morphologically distinct precursor types – growth cone splitting (blue), filopodium (red), lamellipodium/actin wave (green) and a mixed type (yellow). In a second round of analysis, branch type classifications were quality controlled...

... and their subsequent stabilization by nascent adhesions. The actin-binding protein lamellipodin (Lpd) is thought to play a critical role in lamellipodium protrusion, by delivering Ena/VASP proteins onto the growing plus ends of actin filaments and by interacting with the WAVE regulatory complex, an activator...

... Ltd 2015 VICKZ Igf2bp protein Intracellular RNA localization Phagokinetic assay Cell movement Lamellipodium Cofilin The family of VICKZ RNA-binding proteins has been implicated in regulating several aspects of post-transcriptional RNA fates – intracellular RNA localization...

... polymerisation of branched actin networks. In order to identify new SWC regulators, we conducted a screen in Drosophila cells combining proteomics with functional genomics. This screen identified Clathrin heavy chain (CHC) as a protein that binds to the SWC and whose depletion affects lamellipodium formation...

... The Company of Biologists Limited 2006 2006 GTPase-activating protein ARAP3 PI3K Rho Arf Lamellipodium Many cells respond to appropriate signals by forming lamellipodia, dynamic, sheet-like membrane protrusions containing a highly branched actin meshwork. Lamellipodia are points...

... to direct the correct spatial activation of membrane protrusion. * Author for correspondence (e-mail: jtp@virginia.edu ) 16 3 2005 © The Company of Biologists Limited 2005 2005 FAK Cell polarity Cell migration Lamellipodium The migration of cells is essential...

... the effects of Ca 2+ -CaM on the dynamics of the actin cytoskeleton during cell migration. 10 3 2004 © The Company of Biologists Limited 2004 2004 Actin-bundling activity Actin-stabilizing activity Caldesmon Focal adhesion Wound-healing assay Lamellipodium Plasmids pETCaD39...

... adhesions Actin Vinculin Lamellipodium Cell migration is important to many crucial biological functions such as embryogenesis, immune responses, wound healing and cancer metastasis ( Stossel, 1993 ). The process involves a number of well-orchestrated steps including protrusion, adhesion...

... architecture. * Author for correspondence (e-mail: jvsmall@imb.oeaw.ac.at ) 12 2 2002 © The Company of Biologists Limited 2002 2002 Actin Cytoskeleton Lamellipodium Motility Cryo-electron microscopy The first sign of movement of a eukaryotic cell is the protrusion...