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Keywords: LRP6
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Journal Articles
J Cell Sci (2017) 130 (20): 3542–3556.
Published: 15 October 2017
...Hideki Yamamoto; Daisuke Umeda; Shinji Matsumoto; Akira Kikuchi ABSTRACT Low-density lipoprotein (LDL) receptor-related protein 6 (LRP6) was originally identified as a co-receptor of the Wnt signalling pathway and has been shown to be involved in LDL transport. In polarized hepatocytes, many apical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2446–2456.
Published: 15 May 2012
... for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation. G3BP2, a dishevelled-associated protein, is methylated in response to Wnt3a. The Wnt3a-induced LRP6 phosphorylation is attenuated by G3BP2 knockdown, chemical inhibition of methyl transferase activity or expression of methylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (21): 3537–3544.
Published: 1 November 2011
... research. Recent studies on the role of conserved PPPSPxS motifs in the cytoplasmic tail of low-density lipoprotein receptor-related protein (LRP, isoforms 5 and 6) culminated in a biochemical model: Wnt induces the phosphorylation of LRP6 PPPSPxS motifs, which consequently access the catalytic pocket...
Journal Articles
J Cell Sci (2010) 123 (3): 360–368.
Published: 1 February 2010
...Hiroshi Sakane; Hideki Yamamoto; Akira Kikuchi β-catenin-mediated Wnt signaling is crucial in animal development and tumor progression. The phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6), a single-span transmembrane Wnt receptor, plays a vital role in this signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (22): 5305–5314.
Published: 15 November 2005
...Yonghe Li; Jianglei Chen; Wenyan Lu; Lynn M. McCormick; Jianjun Wang; Guojun Bu Wnt co-receptors LRP5 and LRP6 are two members of the low-density lipoprotein receptor family. Receptor-associated protein is not only a specialized chaperone but also a universal antagonist for members of the low...