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Keywords: LRP1
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Journal Articles
J Cell Sci (2019) 132 (15): jcs228213.
Published: 31 July 2019
... and clusterin on tumor metastasis. Notably, the effects of eHsp90α and clusterin were mediated by low-density lipoprotein receptor-related protein 1 (LRP1). Proximity ligation assay and co-immunoprecipitation experiments demonstrated that clusterin participated in eHsp90α–LRP1 complex formation, which enhanced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs217083.
Published: 26 July 2018
.... The cell signaling activity of tPA–PAI1 complex was rescued when the complex was formed with PAI1R 76E , which binds to LRP1 with decreased affinity, by pre-treating cells with the LRP1 antagonist receptor-associated protein and upon LRP1 gene silencing. The inhibitory role of LRP1 in tPA–PAI1 complex...
Journal Articles
J Cell Sci (2015) 128 (18): 3478–3488.
Published: 15 September 2015
...Elisabetta Mantuano; Michael S. Lam; Masataka Shibayama; W. Marie Campana; Steven L. Gonias ABSTRACT NMDA receptors (NMDA-Rs) are ionotropic glutamate receptors, which associate with LDL-receptor-related protein-1 (LRP1) to trigger cell signaling in response to protein ligands in neurons. Here, we...
Journal Articles
J Cell Sci (2012) 125 (14): 3380–3389.
Published: 15 July 2012
... remains unknown. Here we show that the low-density-lipoprotein receptor-related protein-1 (LRP1) mediates the Hh-induced endocytosis of the GPC3–Hh complex, and that this endocytosis is necessary for the Hh-inhibitory activity of GPC3. Furthermore, we demonstrate that GPC3 binds through its HS chains...
Journal Articles
J Cell Sci (2010) 123 (19): 3336–3346.
Published: 01 October 2010
... a mechanism involving protein-protein interaction. We identify the low-density lipoprotein (LDL) receptor-related protein-1, LRP1, as a novel binding partner for pro-cath-D in fibroblasts. Pro-cath-D binds to residues 349–394 of the β chain of LRP1, and is the first ligand of the extracellular domain of LRP1β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (2): 246–255.
Published: 15 January 2010
... ) to its distinctive pathogenic conformation, the two forms of prion protein (PrP) must interact closely. The neuronal receptor that rapidly endocytoses PrP C is the low-density lipoprotein receptor-related protein 1 (LRP1). We show here that on sensory neurons LRP1 is also the receptor that binds...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1495–1498.
Published: 15 May 2009
... HSP90α in turn promotes migration, but not proliferation, of the cells. Disruption of the secretion or extracellular function of HSP90α blocked hypoxia-stimulated HK migration. The ubiquitously expressed surface receptor, LRP1 (LDL-receptor-related protein 1), mediates the HSP90α signaling. Inhibition...
Journal Articles
J Cell Sci (2007) 120 (22): 4009–4015.
Published: 15 November 2007
... for cancer treatment. LDL-receptor-related protein 1 (LRP1) is a receptor for MK. We found that among the four ligand-binding domains of LRP1, the N-terminal half of the second domain (designated as MK-TRAP) had the strongest affinity to MK. MK-TRAP bound to MK, but not to HB-GAM/pleiotrophin, basic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (18): 3188–3199.
Published: 15 September 2007
... The Company of Biologists Limited 2007 2007 Transglutaminase Integrin Fibronectin Cell-matrix adhesion LRP1 Endocytosis Lysosomal degradation Tissue transglutaminase (tTG or TG2, EC 2.3.2.13) belongs to a multigene family of Ca 2+ -dependent protein crosslinking enzymes ( Lorand and Graham...
Includes: Supplementary data